36
Preliminary

Mike Lustgarten

TMAO: Health Risks, Dietary Sources, and Personalized Tracking

TMAO (trimethylamine N-oxide) is associated with cardiovascular and cognitive decline, but its production depends more on gut bacteria composition and intestinal pH than on dietary sources alone. The presenter analyzes 21 personal biomarker tests to track TMAO levels and discusses evidence-based strategies to reduce it through fiber intake and exercise.

55
Promising

Peter Attia

Seed Oils vs. Lard: What the Science Actually Shows

Layne Norton and Peter Attia dive deep into the lipid science comparing seed oils and lard for cooking, concluding that both ultra-processed fried foods are unhealthy regardless of oil type, and that marketing either as 'healthy' is misleading. The discussion emphasizes the importance of reading actual studies rather than social media interpretations.

67
Promising

Dr Brad Stanfield

NMN & NAD Supplements: Debunking the Anti-Aging Hype with Science

Dr. Brad Stanfield critically examines the NAD-boosting supplement trend, tracing it from compelling animal studies to disappointing human clinical trials and failed reproducibility attempts. He argues that despite initial excitement around NMN and NR supplements, recent evidence—including failed Interventions Testing Program studies and Long COVID trials—suggests these supplements don't deliver the anti-aging benefits widely promoted.

66
Promising

Dr Brad Stanfield

Castration & Lifespan: What the Science Actually Shows About Testosterone

A new Nature study finds castration extends lifespan ~10% across animal species and historical Korean eunuchs lived 14-19 years longer, but the mechanism likely involves reduced risky behavior and altered growth hormone pathways—not simply low testosterone. Dr. Stanfield carefully explains why maintaining healthy testosterone levels remains important for human health despite these findings.

41
Preliminary

Mike Lustgarten

Cardiovascular Biomarkers Deep Dive: Mike Lustgarten's 2025 Blood Test #7

Mike Lustgarten analyzes his personal cardiovascular disease biomarkers (lipid panel, lipoprotein(a), apoB, hsCRP) from blood test #7 in 2025, comparing results to literature-based optimal ranges rather than standard lab reference ranges. He demonstrates a self-tracking approach spanning 64+ LDL tests and 30+ triglyceride tests over 10 years to monitor age-related changes, while emphasizing the challenge of optimizing multiple biomarkers simultaneously rather than individual metrics in isolation.