Digital Twins — OutliveHub

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other medRxiv

Multi-Omics Integrative Analysis of the Aspirin-Gut-Brain-Glioma Axis: Transcriptomic, Proteomic, Epigenetic, Mendelian Randomization, and Single-Cell Transcriptomic Evidence Converges on NEO1/Hepcidin Iron Reprogramming and Ferroptosis Vulnerability

Background: Despite epidemiological interest in aspirin's chemopreventive potential against glioma, the underlying multilayered molecular mechanisms spanning gut microbial ecology, COX-2/PGE2 signaling, inter-organ iron homeostasis via the NEO1/hepcidin regulatory axis, epigenetic reprogramming, and ferroptosis have not …

medrxiv (preprint)

39 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other PubMed

Physics-Informed Artificial Intelligence Design of Picomolar Nanobodies Enables Deep Tumor Penetration and High-Contrast Imaging.

The clinical utility of nanobodies in solid tumor therapy is constrained by a fundamental biophysical trade-off: rapid renal clearance necessitates half-life extension, which in turn demands ultrahigh affinity to prevent dissociation from the target under …

Research (Washington, D.C.)

38 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other PubMed

In Silico Discovery of mTOR Inhibitors as Potential Therapeutics for Feline Hypertrophic Cardiomyopathy.

CONTEXT: Feline Hypertrophic Cardiomyopathy (HCM) is a significant health issue, with a current prevalence of 14.7% in cats. The mammalian target of rapamycin (mTOR) is an atypical serine/threonine protein kinase system that also participates in …

Journal of molecular modeling

38 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other PubMed

Computational Modelling of Platysma Muscle Mechanics: Challenging the Isometric Contraction Paradigm and Implications for the Treatment of Neck Bands.

BACKGROUND: Platysmal bands are among the most visible signs of cervical ageing, commonly attributed to focal isometric contraction zones requiring targeted chemodenervation. However, this paradigm is based primarily on indirect imaging and clinical observation, with …

Aesthetic plastic surgery

38 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

A multilayered skin-fat-muscle phantom embedded with thermocouples for non-ablative RF heating: numerical simulation and experimental validation.

BACKGROUND: Non-ablative radiofrequency (RF) skin rejuvenation relies on controlled volumetric heating of skin and subcutaneous tissues. Clinical validation is costly and ethically constrained, while simulations require experimental validation. Existing single-layer phantoms cannot capture electrothermal heterogeneities …

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group

38 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

Performance Evaluation of Highly Uniform Astragalus Polysaccharide/Silk Fibroin Microspheres Fabricated via Microfluidics as Biodegradable Fillers: Collagen Regeneration and Tissue Reaction.

Skin aging results from the synergistic assault of extrinsic environmental factors and intrinsic biological processes. While traditional microsphere implants promote skin rejuvenation through collagen regeneration, their clinical utility is hampered by non-biodegradability and risks such …

Journal of biomedical materials research. Part A

38 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other medRxiv

Testing a Personalized Digital Health Protocol to Boost Resilience in One Individual

Researchers conducted an intensive year-long self-study (N=1) combining time-restricted eating, exercise, Mediterranean diet, and continuous biomarker monitoring to assess how well a healthy person's body adapts to stress. The study demonstrates new methods for tracking …

medrxiv (preprint)

25 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins In Vitro PubMed

How a NAD+ mimic activates the aging-linked SIR2 protein through internal communication networks

Researchers used computer simulations to map how a NAD+ analog activates SIR2, an enzyme linked to aging, by triggering a cascade of conformational changes that act like an internal relay system. They identified a previously …

PLoS computational biology

41 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

Molecular dynamics and energy analysis of ultrasonic cavitation effects on aged asphalt.

The physicochemical degradation of asphalt during long-term service leads to pronounced aging, characterized by increased molecular aggregation, elevated viscosity, and degraded mechanical performance. Ultrasonic treatment has shown potential for reducing the viscosity of heavy oils …

Ultrasonics sonochemistry

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Dual binding modes of Quercetin to BSA: Insights from spectroscopy and molecular simulations in amyloid suppression.

The rising incidence of neurodegenerative disorders linked to protein fibrillation in aging populations highlights the need for efficient, low-toxicity fibrillation inhibitors. Quercetin, a natural flavonoid, shows potential in both suppressing fibrillation and disaggregating mature fibrils. …

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Bisdemethoxycurcumin extends lifespan and healthspan in Caenorhabditis elegans via modulation of EGFR-linked signaling pathways.

Bisdemethoxycurcumin (BDMC) is a natural curcuminoid with higher solubility and stability than curcumin, yet its potential role in lifespan and healthspan regulation remains largely unexplored. This study aimed to investigate the effects of BDMC on …

Food & function

38 Early

Preliminary Biomarkers — Aging clocks and measurement tools Observational bioRxiv

Can MRI scans reveal who's aging faster? A new framework using AI and 70,000 scans

Doctors might someday use MRI scans to spot organs aging too fast and predict disease risk years earlier.

Researchers used artificial intelligence to analyze 70,000 MRI scans and found that medical imaging can detect which organs are aging faster than normal—and these patterns correlate with diseases like MS and COPD, plus lifestyle factors …

biorxiv (preprint)

38 Early

Disputed AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other medRxiv

Computer Model Suggests Combining Four Drugs May Slow Aging Better Than Using Them Alone

A computer model suggests that combining four existing drugs differently might slow aging better than current uses, but human testing is needed.

Researchers built a computer simulation of how aging works in the body and tested which combination of four existing drugs (semaglutide, SGLT2 inhibitors, metformin, and rapamycin) might slow aging most effectively. The model suggests that …

medrxiv (preprint)

21 Weak

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other PubMed

Developing and Internally Validating AI-Based Aging Resilience Biomarkers in Non-Human Primates.

Quantifying biological aging is crucial for understanding functional decline before the onset of morbidity. While many accelerated aging and frailty measures based on clinical data exist for humans and several for rodent models of aging, …

The journals of gerontology. Series A, Biological sciences and medical sciences

46 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

Pectin/tamarind gum-based edible active films reinforced with supramolecularly self-assembled apigenin nanocrystals for shelf-life extension of strawberries.

Apigenin nanocrystals (AN) were synthesized through supramolecular self-assembly and incorporated into a pectin/tamarind gum (PTG) matrix to fabricate edible bio-based nanocomposite films. Scanning electron microscopy (SEM) confirmed that AN exhibits a rod-like nanostructure. Both simulations …

Colloids and surfaces. B, Biointerfaces

38 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other PubMed

AI and longevity medicine: unlocking predictive and preventive strategies for healthy aging.

Longevity medicine is transforming healthcare by shifting the focus from disease treatment toward the preservation of function, resilience, and healthspan. In parallel, artificial intelligence (AI) has emerged as a powerful catalyst accelerating this transition through …

Presse medicale (Paris, France : 1983)

38 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

Atomistic Prediction of the Effects of Structural Differences in Bio-Oil Fatty Acids on Thermodynamic Properties and Rejuvenation Behavior of Aged Bitumen.

Bio-oil is derived from a diverse range of feedstocks with significant differences in fatty acid form (FAF) and unsaturation (FAU), driven by its inherent compositional diversity. However, existing studies often show deviations in the selection …

Langmuir : the ACS journal of surfaces and colloids

38 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Other bioRxiv

A stromal-state dichotomy governs recalcitrance or remission in inflammatory bowel disease

Inflammatory bowel diseases (IBD) remain a relapsing, treatment-refractory disorder marked by progressive tissue injury and inflammation despite expanding immune-targeted therapies. We established a prospective cohort integrating stromal biobanking, functional phenotyping, cross-cohort benchmarking, and outcome modeling …

biorxiv (preprint)

34 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Leonurine Attenuates Ischemia-Reperfusion Injury Through PI3K/AKT/mTOR Pathway in Mouse Liver.

Hepatic ischemia-reperfusion (I/R) injury complicates transplantation, resection, and shock, yet lacks effective pharmacotherapy.

Hepatic ischemia-reperfusion (I/R) injury complicates transplantation, resection, and shock, yet lacks effective pharmacotherapy. We evaluated Leonurine (SCM-198) as a hepatoprotective agent. Male C57BL/6 mice were pretreated with SCM-198 for 7 days, then subjected to hepatic …

Phytotherapy research : PTR Feb 15, 2026

38 Early

Disputed AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other bioRxiv

How Your Brain Uses Predictions to Shape What You See

This paper presents a computational model of how the brain uses predictions and prior knowledge to filter and interpret sensory information. While the model shows promise in explaining existing behavioral and brain imaging data, it's …

biorxiv (preprint) Feb 13, 2026

24 Weak