Computational simulations of human aging for intervention testing
Bio-oil is derived from a diverse range of feedstocks with significant differences in fatty acid form (FAF) and unsaturation (FAU), driven by its inherent compositional diversity. However, existing studies often show deviations in the selection …
Researchers used artificial intelligence to analyze 70,000 MRI scans and found that medical imaging can detect which organs are aging faster than normal—and these patterns correlate with diseases like MS and COPD, plus lifestyle factors …
Researchers built a computer simulation of how aging works in the body and tested which combination of four existing drugs (semaglutide, SGLT2 inhibitors, metformin, and rapamycin) might slow aging most effectively. The model suggests that …
Quantifying biological aging is crucial for understanding functional decline before the onset of morbidity. While many accelerated aging and frailty measures based on clinical data exist for humans and several for rodent models of aging, …
Apigenin nanocrystals (AN) were synthesized through supramolecular self-assembly and incorporated into a pectin/tamarind gum (PTG) matrix to fabricate edible bio-based nanocomposite films. Scanning electron microscopy (SEM) confirmed that AN exhibits a rod-like nanostructure. Both simulations …
Longevity medicine is transforming healthcare by shifting the focus from disease treatment toward the preservation of function, resilience, and healthspan. In parallel, artificial intelligence (AI) has emerged as a powerful catalyst accelerating this transition through …
Researchers conducted an intensive year-long self-study (N=1) combining time-restricted eating, exercise, Mediterranean diet, and continuous biomarker monitoring to assess how well a healthy person's body adapts to stress. The study demonstrates new methods for tracking …
Researchers used computer simulations to map how a NAD+ analog activates SIR2, an enzyme linked to aging, by triggering a cascade of conformational changes that act like an internal relay system. They identified a previously …
The physicochemical degradation of asphalt during long-term service leads to pronounced aging, characterized by increased molecular aggregation, elevated viscosity, and degraded mechanical performance. Ultrasonic treatment has shown potential for reducing the viscosity of heavy oils …
The rising incidence of neurodegenerative disorders linked to protein fibrillation in aging populations highlights the need for efficient, low-toxicity fibrillation inhibitors. Quercetin, a natural flavonoid, shows potential in both suppressing fibrillation and disaggregating mature fibrils. …
Bisdemethoxycurcumin (BDMC) is a natural curcuminoid with higher solubility and stability than curcumin, yet its potential role in lifespan and healthspan regulation remains largely unexplored. This study aimed to investigate the effects of BDMC on …
Hepatic ischemia-reperfusion (I/R) injury complicates transplantation, resection, and shock, yet lacks effective pharmacotherapy. We evaluated Leonurine (SCM-198) as a hepatoprotective agent. Male C57BL/6 mice were pretreated with SCM-198 for 7 days, then subjected to hepatic …
This paper presents a computational model of how the brain uses predictions and prior knowledge to filter and interpret sensory information. While the model shows promise in explaining existing behavioral and brain imaging data, it's …
Researchers developed FastGxC, a computational method that finds genes whose activity changes depending on tissue or cell type context—a key mechanism in disease risk. The tool is a million times faster than existing approaches and …
Researchers created a computational model that simulates how fruit fly larvae move, navigate, and learn—combining physics-based locomotion with neural circuits and behavior. This tool could help neuroscientists test theories about how brains control behavior without …
This meta-analysis of 45 neuroimaging studies (1,273 participants) identified distinct brain regions that process rewards and task difficulty separately, then integrate them to decide whether mental effort is worth the reward. The findings clarify how …