AlphaFold and protein structure prediction in aging research
Researchers used computer simulations to map how a NAD+ analog activates SIR2, an enzyme linked to aging, by triggering a cascade of conformational changes that act like an internal relay system. They identified a previously …
Researchers discovered that naked mole rats—which live 10x longer than similar-sized rodents—have undergone massive evolutionary changes in protein structure, particularly in regions that handle stress and prevent cancer. These changes appear to stabilize certain proteins …
Researchers used advanced imaging and mass spectrometry to map how insulin receptors behave in muscle cells, discovering they travel via two different cellular pathways—one involving caveolin and one involving clathrin. This fundamental understanding of insulin …