Longevity of humoral response in recipients of rabies pre-exposure prophylactic vaccination with Abhayrab®.

The results of a retrospective analysis of data on rabies virus neutralizing antibody titers of occupationally at-risk individuals receiving vaccination with Abhayrab®, a Vero cell culture-derived inactivated rabies vaccine, are communicated. While rabies vaccines generally elicit strong immunity, specific data on the long-term efficacy of Abhayrab® was previously lacking. The data on neutralizing antibody titers of occupationally immunized individuals receiving a three-dose prophylactic intramuscular regimen (0.5 mL on days 0, 7, and 28) were analyzed retrospectively to evaluate the longevity of humoral response. The data were also used to assess the impact of sex of the individual, their marital status, and age on the humoral response. Our analyses demonstrated that pre-exposure prophylaxis with Abhayrab® elicited protective antibody titers persisting for up to 12 years. The vaccine successfully induced protection in individuals up to 69 years of age. Further, immune responses were not unfavorably influenced by age, sex, or marital status of the individual, and the vaccine maintained a high safety profile. The results of the analyses confirm that a single prophylactic course of Abhayrab® provides broad, long-lived protection. These findings reinforce the clinical importance of preventive vaccination for at-risk populations and support the vaccine's sustained efficacy over a decade post-administration.