Research on cellular-level aging mechanisms
Cellular senescence drives inflammation and tissue breakdown and is a key hallmark of aging. The accumulation of senescent cells is strongly linked to the degeneration of spinal tissues and back pain. Here, we show that …
Cryopreservation, or cryonics, is an experimental procedure that preserves individuals at cryogenic temperatures after legal death in the hope of future revival. Although Switzerland hosts the Schengen Area's first dedicated whole-body human cryopreservation facility, public …
This study evaluated protein hydrolysates derived from Turkmen melon seeds (TMSPH), produced using Protamex, as bioactive components in a polyethylene (PL)-nanoclay (NC) edible nanocomposite coating for extending the shelf life of button mushrooms. Five treatments …
The hippocampus is a central hub of human memory and cognition and is closely associated with brain disorders. Studies have shown that it exhibits complex structural variation across the lifespan, yet the details of hippocampal …
Biochemical degradation occurs in fruits stored under poor conditions. It negatively affects physical properties, such as color and firmness, while also reducing key nutrients, including antioxidants, phenols, vitamins, and flavonoids. This study explores the use …
Researchers discovered that a cellular recycling process called ER-phagy actively remodels the endoplasmic reticulum (the cell's protein-making factory) as we age—shifting its structure and composition in coordinated ways. Remarkably, this same remodeling process is also …
Researchers treated female mice with fatty liver disease (MASLD) using senolytic drugs—compounds that eliminate senescent (aged) cells—and found pregnancy rates improved, particularly through reduced aging and inflammation in the ovaries. However, the treatment had limited …
BACKGROUND: Combined anterior cruciate ligament (ACL) and medial collateral ligament (MCL) injuries are common in professional sport, but there is little evidence available regarding the long-term impact of them on players' sporting careers. PURPOSE: To …
This research explores synthesis of silver-salicylic acid nanoparticles (AgNPs-SA) and their integration with carboxymethyl cellulose (CMC) to form CMC-AgNPs-SA and with chitosan to form Ch-AgNPs-SA. The effects of these composite materials were evaluated in terms …
Researchers discovered that aging planarians (regenerative flatworms) lose fertility not because their stem cells fail, but because their body's positional 'blueprint' gradually shifts out of alignment. By manipulating the molecular signals that control body polarity, …
This review examines how C. elegans worms switch their mitochondrial energy-production machinery to survive low-oxygen or toxic conditions, and how mild damage to this system can actually extend lifespan. The findings suggest conserved cellular stress-response …
The physicochemical degradation of asphalt during long-term service leads to pronounced aging, characterized by increased molecular aggregation, elevated viscosity, and degraded mechanical performance. Ultrasonic treatment has shown potential for reducing the viscosity of heavy oils …
Apigenin nanocrystals (AN) were synthesized through supramolecular self-assembly and incorporated into a pectin/tamarind gum (PTG) matrix to fabricate edible bio-based nanocomposite films. Scanning electron microscopy (SEM) confirmed that AN exhibits a rod-like nanostructure. Both simulations …
This review examines FOXO4-DRI, a designed peptide that kills senescent (aged) cells by disrupting a protein interaction linked to brain aging. Animal studies show it improves memory and reverses some Alzheimer's-like damage, while early human …
Researchers developed a new tool to watch autophagy (cellular recycling) in real time in naked mole-rat cells and discovered that these long-lived animals respond to stress by forming temporary vacuoles—a protective response that reverses when …
Scientists discovered that the famous longevity benefit of reducing IGF-1 signaling completely fails in mice with defective mitochondrial DNA. This reveals that mitochondrial health is a prerequisite for many anti-aging pathways to work, suggesting future …
Mesenchymal stem cell-derived exosomes (Exo) have emerged as potent therapeutic agents for skin regeneration; however, their clinical translation is often impeded by poor colloidal stability and the formidable barrier of the stratum corneum. In this …
Lower eyelid plasty is important for facial rejuvenation. Tear trough deformities and eyebags are among the most common and urgent problems encountered in lower eyelid aesthetic surgery. Compared with fillers such as hyaluronic acid and …
Gait variability is a critical functional indicator of dynamic balance and neurocognitive decline in health. Its translation into clinical practice is, however, challenged by a lack of age-related normative trajectories and reference values under real-world …
The use of high-power lasers for facial rejuvenation has been growing every year. In particular, the Thulium laser in non-ablative mode has gained prominence due to its safety, postoperative comfort, and wide clinical indication. This …