Cellular

Research on cellular-level aging mechanisms

Autophagy Mitochondria mTOR Pathway Senescence Senolytics Stem Cells
Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

A Protein Called ATG-18 Extends Lifespan Without Needing Its Usual Autophagy Role

Scientists found a longevity protein that works through an unexpected pathway, suggesting new targets for aging drugs.

Researchers discovered that ATG-18, a protein known for triggering cellular cleanup, extends lifespan in worms through a completely different mechanism than expected. The protein interacts with a metabolic enzyme (PCK-2) to relay signals from the …

Aging cell
44 Early
Design 6
Sample 9
Peer Review 15
Replication 5
Transparency 9
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

The association of frailty with age and lifespan in mice differs by strain and sex.

Frailty indices have been assessed in mouse models for more than a decade, but the effect of sex and strain on frailty outcomes remains poorly understood. Here, we collated and harmonized item-level 31-item clinical frailty …

The journals of gerontology. Series A, Biological sciences and medical sciences
46 Early
Design 5
Sample 7
Peer Review 18
Replication 6
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

Digital Technologies for Healthy Longevity: A Policy Agenda from the Einstein Circle on Inclusive, Data-Driven Ageing Societies.

BACKGROUND: Rapid population ageing presents one of the defining global health challenges of the twenty-first century. While digital technologies are increasingly used to support older adults, their deployment often remains fragmented, inequitable, and insufficiently guided …

Ageing research reviews
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

Functional chitosan/starch composite films enriched with Aloe vera extract for antimicrobial and antioxidant packaging: Shelf-life study on chicken meat and shrimp.

Functional chitosan/starch composite films enriched with aloe vera extract were developed as sustainable active packaging materials using a one-pot preparation method and optimized by response surface methodology (RSM). The effects of chitosan, Dioscorea esculenta starch, …

International journal of biological macromolecules
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How cells clean up their protein factories as we age

Your cells actively recycle and reorganize their protein-making machinery as you age, and this process appears to be essential for living longer.

Researchers discovered that a cellular recycling process called ER-phagy actively remodels the endoplasmic reticulum (the cell's protein-making factory) as we age—shifting its structure and composition in coordinated ways. Remarkably, this same remodeling process is also …

Autophagy
46 Early
Design 4
Sample 9
Peer Review 13
Replication 10
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

Can senolytic drugs restore fertility in female mice with fatty liver disease?

Researchers treated female mice with fatty liver disease (MASLD) using senolytic drugs—compounds that eliminate senescent (aged) cells—and found pregnancy rates improved, particularly through reduced aging and inflammation in the ovaries. However, the treatment had limited …

Biology of reproduction
39 Early
Design 6
Sample 6
Peer Review 13
Replication 5
Transparency 9
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms In Vitro bioRxiv

Keeping Cells Fit in Old Age by Rewiring a Key Metabolic Switch

Researchers found a way to keep old cells working well by tweaking one metabolic switch, suggesting aging loss of fitness isn't inevitable.

Researchers found that activating a protein called AMPK can prevent aging-related fitness decline in yeast cells, but only if you also prevent it from shutting down fat production—a dual problem that a specially engineered AMPK …

biorxiv (preprint)
30 Early
Design 6
Sample 7
Peer Review 3
Replication 5
Transparency 9
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How worm mitochondria adapt to stress and live longer

Mild stress on cellular power plants may trigger protective cleanup systems that extend lifespan, a mechanism conserved across species.

This review examines how C. elegans worms switch their mitochondrial energy-production machinery to survive low-oxygen or toxic conditions, and how mild damage to this system can actually extend lifespan. The findings suggest conserved cellular stress-response …

Experimental cell research
41 Early
Design 4
Sample 2
Peer Review 14
Replication 12
Transparency 9
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

Swiss public attitudes to human cryopreservation.

Cryopreservation, or cryonics, is an experimental procedure that preserves individuals at cryogenic temperatures after legal death in the hope of future revival. Although Switzerland hosts the Schengen Area's first dedicated whole-body human cryopreservation facility, public …

PloS one
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

A facile tannic acid/gentamicin-loaded biodegradable silk fibroin lifting thread with robust mechanical and antibacterial properties.

Facial thread lifting is widely employed in minimally invasive rejuvenation for its rapid recovery. However, its clinical acceptance is heavily limited by common complications, particularly local infections and severe inflammatory responses. Herein, a multifunctional silk …

Bioresource technology
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Other bioRxiv

Immunomodulatory Effects of Insulin-Derived Fibrils from Infusion Pumps: Role of Phenolic Preservatives in Macrophage Activation

Background: Protein fibrillation represents a critical challenge in therapeutic insulin delivery, yet the structural determinants and immunological consequences of insulin-derived fibrils (IDFs) formed in the presence of phenolic preservatives remain poorly characterized. Objective: This study …

biorxiv (preprint)
34 Early
Design 5
Sample 7
Peer Review 4
Replication 6
Transparency 12
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms In Vitro bioRxiv

Naked mole-rats handle cell stress differently: a closer look at their autophagy system

Researchers developed a new tool to watch autophagy (cellular recycling) in real time in naked mole-rat cells and discovered that these long-lived animals respond to stress by forming temporary vacuoles—a protective response that reverses when …

biorxiv (preprint)
30 Early
Design 5
Sample 6
Peer Review 3
Replication 5
Transparency 11
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

Permanent Complications After Dermal Fillers: Risks, Prevention, and Management Strategies.

BACKGROUND: Dermal fillers are widely utilized in esthetic medicine for soft tissue augmentation and facial rejuvenation. Generally safe, complications are mostly minor. Permanent complications, though rare, are disastrous and overwhelmingly caused by insufficient understanding of …

Aesthetic plastic surgery
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

Ayurvedic nutraceutical, Chyawanprash, enhances longevity and stress resilience via mitochondrial and muscular health in C. elegans model of ageing.

Chyawanprash is an ancient Ayurvedic superfood described for its antioxidant, anti-ageing and immunity-boosting properties. Prolonged exposure to environmental stressors such as extreme heat, air pollution and toxins could lead to several diseases by triggering oxidative …

Experimental gerontology
44 Early
Design 5
Sample 7
Peer Review 16
Replication 6
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

Specificity and longevity of a bacterial interspecies mutual cooperation benefiting organic micropollutant biodegradation.

UNLABELLED: Aminobacter niigataensis MSH1 is a candidate for bioaugmentation of sand filters in drinking water treatment plants (DWTP), as it mineralizes the ubiquitous groundwater micropollutant 2,6-dichlorobenzamide (BAM). The DWTP sand filter isolate Piscinibacter sp. K169 …

Applied and environmental microbiology
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

Comparative Evaluation of Argon and Helium Plasma for Controlled Epidermal Peeling and Dermal Remodeling in Human Skin Tissue.

BACKGROUND: Plasma-based devices are increasingly used for skin rejuvenation and epidermal peeling; however, standardized parameters for different plasma gases remain insufficient. Argon (Ar) and helium (He) plasma exhibit distinct physical and biological characteristics, necessitating systematic …

Aesthetic plastic surgery
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Other bioRxiv

Lamellar Normative Modelling of the Hippocampus Across the Human Lifespan

The hippocampus is a central hub of human memory and cognition and is closely associated with brain disorders. Studies have shown that it exhibits complex structural variation across the lifespan, yet the details of hippocampal …

biorxiv (preprint)
34 Early
Design 5
Sample 7
Peer Review 4
Replication 6
Transparency 12
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

Performance enhancement of chitosan/hydroxypropyl starch blend casing by cinnamaldehyde cross-linking and its application in sausage preservation.

Traditional collagen casings struggle to meet the preservation requirements for high-quality sausages due to their limited functionality and inadequate performance in high-humidity environments. This study aimed to develop a novel casing that combines excellent physical …

International journal of biological macromolecules
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

Nitric oxide in Extracorporeal Membrane Oxygenation Sweep Gas Promotes Oxygenator Longevity: A Technical Case Report.

In the accompanying article in this issue, we reported the survival of a 4 month old infant with severe necrotizing pneumonia due to respiratory syncytial virus (RSV) and methicillin-resistant Staphylococcus aureus (MRSA), resulting in cardiogenic …

ASAIO journal (American Society for Artificial Internal Organs : 1992)
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →