Research on cellular-level aging mechanisms
BACKGROUND: Hematopoietic stem cell therapy is a cornerstone of regenerative medicine for treating haematological and immunological disorders. While autologous HSCs avoid the complications of graft-versus-host disease, current expansion protocols often rely on expensive synthetic media …
Premature ovarian insufficiency (POI) and early menopause (EM) affect millions of women worldwide. Compared with normal menopause, they confer a longer duration of estrogen deficiency and are associated not only with a shorter lifespan, but …
Objective: Neuromodulation therapies are becoming increasingly common as a therapeutic strategy to treat neurological disorders and deficits. Despite their widespread use, the frameworks used to evaluate device longevity and electrochemical safety are limited, producing variable …
UNLABELLED: Aminobacter niigataensis MSH1 is a candidate for bioaugmentation of sand filters in drinking water treatment plants (DWTP), as it mineralizes the ubiquitous groundwater micropollutant 2,6-dichlorobenzamide (BAM). The DWTP sand filter isolate Piscinibacter sp. K169 …
Chyawanprash is an ancient Ayurvedic superfood described for its antioxidant, anti-ageing and immunity-boosting properties. Prolonged exposure to environmental stressors such as extreme heat, air pollution and toxins could lead to several diseases by triggering oxidative …
Cryopreservation, or cryonics, is an experimental procedure that preserves individuals at cryogenic temperatures after legal death in the hope of future revival. Although Switzerland hosts the Schengen Area's first dedicated whole-body human cryopreservation facility, public …
Researchers discovered that a cellular recycling process called ER-phagy actively remodels the endoplasmic reticulum (the cell's protein-making factory) as we age—shifting its structure and composition in coordinated ways. Remarkably, this same remodeling process is also …
This is a review of modified mRNA (mmRNA) science and a description of a novel application of mmRNA for the creation of personalized cosmetic products.
Researchers treated female mice with fatty liver disease (MASLD) using senolytic drugs—compounds that eliminate senescent (aged) cells—and found pregnancy rates improved, particularly through reduced aging and inflammation in the ovaries. However, the treatment had limited …
Frailty indices have been assessed in mouse models for more than a decade, but the effect of sex and strain on frailty outcomes remains poorly understood. Here, we collated and harmonized item-level 31-item clinical frailty …
This review examines how C. elegans worms switch their mitochondrial energy-production machinery to survive low-oxygen or toxic conditions, and how mild damage to this system can actually extend lifespan. The findings suggest conserved cellular stress-response …
Traditional collagen casings struggle to meet the preservation requirements for high-quality sausages due to their limited functionality and inadequate performance in high-humidity environments. This study aimed to develop a novel casing that combines excellent physical …
The effect of combination of fig latex and sodium phytate on the quality and shelf life of cooked beef leg muscles during refrigerated storage was tested. The greatest textural improvement was obtained with the combination …
Facial thread lifting is widely employed in minimally invasive rejuvenation for its rapid recovery. However, its clinical acceptance is heavily limited by common complications, particularly local infections and severe inflammatory responses. Herein, a multifunctional silk …
Immune reset is increasingly invoked to describe the possibility that a one-off intervention is able to produce durable treatment-free control of rheumatic autoimmune diseases. However, the term remains imprecise and is often conflated with lymphodepletion …
Background: Protein fibrillation represents a critical challenge in therapeutic insulin delivery, yet the structural determinants and immunological consequences of insulin-derived fibrils (IDFs) formed in the presence of phenolic preservatives remain poorly characterized. Objective: This study …
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Researchers developed a new tool to watch autophagy (cellular recycling) in real time in naked mole-rat cells and discovered that these long-lived animals respond to stress by forming temporary vacuoles—a protective response that reverses when …
BACKGROUND: Dermal fillers are widely utilized in esthetic medicine for soft tissue augmentation and facial rejuvenation. Generally safe, complications are mostly minor. Permanent complications, though rare, are disastrous and overwhelmingly caused by insufficient understanding of …
Longevity and stress resilience require precise coordination of gene expression programs across tissues. Here, we demonstrate that overexpression of the chromatin reader bet-1 specifically in neurons of Caenorhabditis elegans promotes organismal longevity and stress resistance …