Cellular senescence and the senescence-associated secretory phenotype (SASP)
Chemotherapeutic treatment of breast cancer with Doxorubicin (DOX) can induce tumor and stromal cell senescence leading to therapy-resistance. Senescence-associated secretory phenotype (SASP) promotes secretion of pro-inflammatory and tumorigenic factors causing systemic inflammation. Combined, this can …
Researchers found that mocetinostat, a drug that inhibits certain histone deacetylases, selectively kills senescent (aged) chondrocytes—cells that accumulate in arthritic joints—while leaving healthy cells intact. This discovery could lead to a new class of "senolytic" …
This review examines cellular senescence (aging cells that stop dividing) in muscle regeneration, finding that senescent cells play a dual role: they can briefly help repair muscle after injury, but when they accumulate in aging …
Researchers reviewed how people who live to 100+ maintain surprisingly youthful immune function despite extreme age, resisting the chronic inflammation and immune decline that typically accompany aging. They identified several biological mechanisms—including controlled inflammatory pathways, …
This review synthesizes evidence that natural killer (NK) cells—a type of immune cell—undergo age-related changes that impair their ability to clear damaged cells and regulate inflammation, contributing to aging-related diseases. The authors propose NK cell …
Researchers found that lifelong restriction of valine, a branched-chain amino acid in protein, improved metabolic health and reduced aging markers in both male and female mice, but only extended lifespan in males by 23%. The …
Immunosenescence, an age-associated decline in immune function, is increasingly recognized as a central determinant of health and disease in older adults. Characterized by thymic involution, loss of naïve T cells, contraction of T cell receptor …
Clove (Syzygium aromaticum) extracts promote longevity in several model systems, yet the underlying molecular mechanisms responsible for the pro-longevity remain poorly defined. This study utilized a Saccharomyces cerevisiae model to investigate how clove extracts modulate …
Researchers treated female mice with fatty liver disease (MASLD) using senolytic drugs—compounds that eliminate senescent (aged) cells—and found pregnancy rates improved, particularly through reduced aging and inflammation in the ovaries. However, the treatment had limited …
During mitotic growth, Saccharomyces cerevisiae cells age by dividing asymmetrically producing young daughter cells while retaining age-associated damage in the mother cell, which will eventually become senescent. Gametogenesis naturally and completely resets precursor cell lifespan, …
Researchers found that activating a protein called AMPK can prevent aging-related fitness decline in yeast cells, but only if you also prevent it from shutting down fat production—a dual problem that a specially engineered AMPK …
BackgroundWhile immunologic aging impacts immune responses to vaccination, consistent biomarkers associated with aging of the immune system and suboptimal serologic response to influenza vaccination have not been well-studied. Identification of readily measurable biomarkers of immunosenescence …
This review examines how immunosenescence (age-related immune decline) drives lung diseases like COPD, fibrosis, and cancer, and surveys emerging treatments including senolytics, stem cell therapy, and lifestyle interventions. While it synthesizes current knowledge well, it's …
This review examines 'partial reprogramming'—a technique that temporarily activates rejuvenation factors to reverse aging hallmarks in cells and tissues without turning them into cancer-prone stem cells. Early evidence suggests it can restore tissue function and …
Ageing and interventions modulate health and mortality1, yet the underlying molecular mechanisms of this modulation remain unclear. Here we integrate more than 11,000 transcriptomes from more than 25 tissues across 4 mammals (mouse, rat, macaque …
Researchers created a gel containing special vesicles from stem cells that reduces inflammation and cellular aging in aging bone, significantly improving bone and tendon healing in an osteoporosis model. This demonstrates a novel 'senomorphic' approach—directly …
The conserved Ess1 prolyl isomerase (PIN1 in human) binds the carboxy-terminal domain (CTD) of RNA Pol II, and plays multiple roles in transcription regulation. Consistent with an essential role of the human PIN1 in telomere …
Researchers from multiple labs independently tested two widely-publicized senolytic drugs (a GLS1 inhibitor and anti-PD-1 antibody) and found they did not reduce senescent cells or improve aging in mice—contradicting earlier claims. This highlights a serious …
This review challenges the assumption that senescent cells are always harmful, showing that some actually support healthy aging through wound healing and tissue maintenance. The authors propose a new strategy: prevent bad senescence while selectively …
This review examines how lysosomes—cellular recycling centers—actively regulate aging through two newly discovered signaling pathways (lysosomal surveillance response and transgenerational lysosomal signaling) and the protein TFEB. These findings suggest targeting lysosomal activity could be a …