Stem Cells

Stem cell exhaustion, regeneration, and rejuvenation

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Review / Commentary PubMed

How aging immune systems damage lungs—and what treatments might help

If your immune system ages slower, your lungs might stay healthier longer—but we need better treatments to prove it works.

This review examines how immunosenescence (age-related immune decline) drives lung diseases like COPD, fibrosis, and cancer, and surveys emerging treatments including senolytics, stem cell therapy, and lifestyle interventions. While it synthesizes current knowledge well, it's …

BMC medicine
36 Early
Design 4
Sample 2
Peer Review 13
Replication 7
Transparency 10
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

From complexity to clarity: aging bone marrow niche in bone and blood regeneration and malignancy.

The bone marrow niche (BMN) plays a central role in regulating hematopoietic stem-cell (HSC) maintenance, lineage commitment, and immune homeostasis, while also supporting osteogenesis and maintaining skeletal integrity. Once considered static, the BMN is now …

Bone research
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

P-selectin delineates conserved functional heterogeneity in early hematopoietic stem cell aging in humans and mice.

Progressive aging of bone marrow hematopoietic stem cells (HSCs) underlies clonal hematopoiesis and age-associated hematologic disorders. Defining early molecular events driving HSC functional decline is essential for rejuvenation strategies. Here, we identify P-selectin (Selp) as …

The EMBO journal
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

A Dual Approach to Glioblastoma Treatment with Epigenetic Reprogramming and Neurogenetic Modulation.

Glioblastoma is a highly aggressive primary brain tumour marked by extensive genomic and epigenomic alterations, cellular heterogeneity, and therapeutic resistance. Despite maximal surgical resection followed by chemoradiotherapy, median survival remains approximately 15 months, reflecting the …

Carcinogenesis
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

The Role of Exercise in Regulating Histone Modifications and Non-coding RNAs in Muscle Aging and Sarcopenia.

Sarcopenia, the progressive loss of skeletal muscle mass and function with age, is a major contributor to frailty and decreased quality of life in older adults. While physical exercise remains the most effective intervention, its …

Biochemical genetics
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

Can we reverse aging by partially reprogramming cells?

This review examines 'partial reprogramming'—a technique that temporarily activates rejuvenation factors to reverse aging hallmarks in cells and tissues without turning them into cancer-prone stem cells. Early evidence suggests it can restore tissue function and …

Trends in molecular medicine
36 Early
Design 4
Sample 2
Peer Review 13
Replication 7
Transparency 10
How we score →
Preliminary Biomarkers — Aging clocks and measurement tools Other PubMed

Thioredoxin h1-targeted proteins in European beech (Fagus sylvatica L.): Insights into metabolic control, stress response, and seed longevity.

Seed viability and longevity underpin forest regeneration under changing environmental conditions. European beech (Fagus sylvatica L.) produces intermediate seeds that gradually lose viability during storage, largely through oxidative stress, which makes redox homeostasis central to …

PloS one
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Promising Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Traditional Chinese Medicine Formulas in Delaying Aging: From Theoretical Foundations to Molecular Mechanisms and Translational Perspectives.

Aging is a systemic decline in physiological integrity, driving chronic diseases such as neurodegeneration, cardiovascular disorders, and metabolic syndromes. Rapid global population aging urgently demands effective interventions. Traditional Chinese medicine (TCM) formulas, characterized by multi-component, …

Journal of cellular and molecular medicine
51 Promising
Design 5
Sample 7
Peer Review 18
Replication 6
Transparency 15
How we score →
Preliminary Biomarkers — Aging clocks and measurement tools Other PubMed

The Role of EVs in the Aging Hematopoietic System.

Extracellular vesicles (EVs) are membrane-enclosed nanoparticles that mediate intercellular communication by transferring proteins, nucleic acids, and lipids. Within the hematopoietic system, EVs orchestrate critical signaling between bone marrow (BM) niche cells and hematopoietic stem and …

Aging cell
49 Early
Design 5
Sample 7
Peer Review 16
Replication 6
Transparency 15
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

A metabolic-epigenetic switch governs multicellular cardiac repair following succinate dehydrogenase inhibition.

Cardiac regeneration is limited in the adult mammalian heart because of restricted cardiomyocyte proliferation and persistent fibrosis. We previously demonstrated that transient pharmacological inhibition of succinate dehydrogenase (SDH) with malonate promotes regeneration after myocardial infarction. …

Nature cardiovascular research
46 Early
Design 5
Sample 7
Peer Review 18
Replication 6
Transparency 10
How we score →
Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

The NLRC4 Inflammasome Drives Myelodysplastic Syndrome by Linking Epigenetic Reprogramming and Innate Immune Signaling.

Myelodysplastic syndromes (MDS), which are hematopoietic stem cell malignancies, are often accompanied by signs of chronic inflammation, that can in turn drive the pathogenetic process. The precise mechanisms dysregulating inflammatory and innate immune signaling in …

Blood advances
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

Why Aging Cells Sometimes Help—and Sometimes Hurt—Muscle Repair

Understanding how aging cells block muscle repair could lead to new treatments to help older adults stay strong and independent.

This review examines cellular senescence (aging cells that stop dividing) in muscle regeneration, finding that senescent cells play a dual role: they can briefly help repair muscle after injury, but when they accumulate in aging …

Cell regeneration (London, England)
37 Early
Design 4
Sample 2
Peer Review 15
Replication 7
Transparency 9
How we score →
Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Caloric restriction rejuvenates aged adult stem cells: From mechanisms to interventions.

Adult stem cells are essential for maintaining tissue homeostasis and facilitating tissue repair. The ability of aged stem cells to generate functional progeny declines, which is closely associated with the onset and progression of age-related …

Ageing research reviews
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

DNMT3A/TET2-mediated epigenetic alteration in Type-1 diabetes dysregulates the haematopoiesis.

Type 1 diabetes (T1D) is an autoimmune disorder characterized by insulin deficiency and hyperglycemia, driven by environmental insults and epigenetic reprogramming beyond genetic predisposition. Recent evidence suggests that systemic epigenetic dysregulation in T1D influences the …

Molecular biology reports
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other bioRxiv

Targeting therapy-induced senescence across multiple breast cancer subtypes in a metastatic bone-like microenvironment

Chemotherapeutic treatment of breast cancer with Doxorubicin (DOX) can induce tumor and stromal cell senescence leading to therapy-resistance. Senescence-associated secretory phenotype (SASP) promotes secretion of pro-inflammatory and tumorigenic factors causing systemic inflammation. Combined, this can …

biorxiv (preprint)
34 Early
Design 5
Sample 7
Peer Review 4
Replication 6
Transparency 12
How we score →
Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other PubMed

Deep Learning Predicts Hematopoietic Stem Cell Aging From 3D Chromatin Images.

The functional decline of the hematopoietic system during aging affects organismal function and contributes to reduced healthspan. Quantifying hematopoietic aging holds great scientific and clinical relevance. Alterations in chromatin architecture are a well-established hallmark of …

Aging cell
49 Early
Design 5
Sample 7
Peer Review 16
Replication 6
Transparency 15
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

Hydrogel-based senomorphic approaches to modulate cellular senescence and promote tissue rejuvenation.

Cellular senescence is a major driver of age-related tissue dysfunction, characterized by chronic inflammation, oxidative stress, mitochondrial impairment, and disrupted extracellular matrix homeostasis. While senolytic strategies that eliminate senescent cells have shown therapeutic promise, irreversible …

Journal of controlled release : official journal of the Controlled Release Society
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Other bioRxiv

Nora virus proliferates in dividing intestinal stem cells and thereby sensitizes Drosophila flies to Pseudomonas aeruginosa intestinal infection and to oxidative stress

The digestive tract represents the most complex interface of an organism with its biotope. Food may be contaminated by pathogens and toxicants while an abundant and complex microbiota thrives in the gut lumen. The organism …

biorxiv (preprint)
39 Early
Design 5
Sample 7
Peer Review 4
Replication 6
Transparency 17
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Restoration of aged liver regeneration by youthful systemic factors via LTβ-driven hepatocyte reprogramming.

BACKGROUND & AIMS: The regenerative capacity of the liver decreases with age, limiting surgical options for elderly patients. While youthful systemic factors can reverse liver aging, the underlying mediators remain unclear. This study aimed to …

Journal of hepatology
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

Sustainable CO2 capture using acid activated alkaline sludge from photovoltaic industry: longevity and recyclability study.

Recycling industrial wastage offers an effective strategy to mitigate waste discharge, promoting development of low-cost CO2 adsorbents aligning with the principles of the circular economy. This study utilized waste alkaline sludge (AS) originated from the …

Environmental science and pollution research international
46 Early
Design 5
Sample 7
Peer Review 18
Replication 6
Transparency 10
How we score →