Stem Cells

Stem cell exhaustion, regeneration, and rejuvenation

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Review / Commentary PubMed

How aging immune systems damage lungs—and what treatments might help

If your immune system ages slower, your lungs might stay healthier longer—but we need better treatments to prove it works.

This review examines how immunosenescence (age-related immune decline) drives lung diseases like COPD, fibrosis, and cancer, and surveys emerging treatments including senolytics, stem cell therapy, and lifestyle interventions. While it synthesizes current knowledge well, it's …

BMC medicine
36 Early
Design 4
Sample 2
Peer Review 13
Replication 7
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How Replacing Damaged Cells and Tissues Could Reverse Aging

Scientists propose strategies to repair and replace damaged body parts to reverse aging, rather than just slow it down.

This perspective paper proposes that replacing damaged cellular and tissue components—rather than just slowing aging—could reverse age-related decline and extend healthy lifespan. Leading longevity researchers outline a roadmap for developing these 'replacement-based' therapies and combining …

Aging cell
34 Early
Design 4
Sample 2
Peer Review 15
Replication 2
Transparency 11
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

From complexity to clarity: aging bone marrow niche in bone and blood regeneration and malignancy.

The bone marrow niche (BMN) plays a central role in regulating hematopoietic stem-cell (HSC) maintenance, lineage commitment, and immune homeostasis, while also supporting osteogenesis and maintaining skeletal integrity. Once considered static, the BMN is now …

Bone research
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Hyperbranched poly(β-amino ester)s-mediated delivery of engineered Klotho mRNA rescues senescence and restores cellular homeostasis in aged and Klotho deficient iMSCs.

A decline in Klotho expression is a defining feature of aging and contributes to cellular dysfunctions. Here, we developed an engineered IVT Klotho mRNA incorporating ARCA capping. Ψ-modification and poly(A) tailing, delivered using a hyperbranched …

Drug delivery and translational research
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

The Role of Exercise in Regulating Histone Modifications and Non-coding RNAs in Muscle Aging and Sarcopenia.

Sarcopenia, the progressive loss of skeletal muscle mass and function with age, is a major contributor to frailty and decreased quality of life in older adults. While physical exercise remains the most effective intervention, its …

Biochemical genetics
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

Rethinking senescent cells: When to stop them, when to keep them

Some aging cells help your body work properly; new strategies could clear harmful ones while keeping helpful ones.

This review challenges the assumption that senescent cells are always harmful, showing that some actually support healthy aging through wound healing and tissue maintenance. The authors propose a new strategy: prevent bad senescence while selectively …

Aging
37 Early
Design 4
Sample 2
Peer Review 13
Replication 9
Transparency 9
How we score →
Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Animal Model PubMed

Remote control for genes: Using electromagnetic fields to turn aging genes on and off

New tool lets scientists turn aging genes on and off from outside the body, offering a way to test anti-aging therapies that weren't possible before.

Scientists developed a technology that uses electromagnetic fields to remotely activate specific genes in living mice with precise timing and location control. They tested it by partially reversing aging processes, modeling Alzheimer's disease, and treating …

Cell
48 Early
Design 6
Sample 8
Peer Review 19
Replication 5
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

New hydrogel with stem cell vesicles reverses aging damage in bone healing

Researchers created a gel that helps aging bones heal better by reducing inflammation and protecting stem cells from aging damage.

Researchers created a gel containing special vesicles from stem cells that reduces inflammation and cellular aging in aging bone, significantly improving bone and tendon healing in an osteoporosis model. This demonstrates a novel 'senomorphic' approach—directly …

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
42 Early
Design 6
Sample 6
Peer Review 16
Replication 5
Transparency 9
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Multidimensional regulatory networks of drug resistance in colorectal cancer: from molecular mechanisms to novel therapeutic counterstrategies.

Colorectal cancer (CRC) remains a major cause of cancer-related mortality, and the widespread occurrence of drug resistance constitutes a central bottleneck that constrains therapeutic efficacy and adversely affects long-term patient outcomes. Current therapeutic strategies, guided …

Biochemical pharmacology
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

A Dual Approach to Glioblastoma Treatment with Epigenetic Reprogramming and Neurogenetic Modulation.

Glioblastoma is a highly aggressive primary brain tumour marked by extensive genomic and epigenomic alterations, cellular heterogeneity, and therapeutic resistance. Despite maximal surgical resection followed by chemoradiotherapy, median survival remains approximately 15 months, reflecting the …

Carcinogenesis
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

Why Aging Cells Sometimes Help—and Sometimes Hurt—Muscle Repair

Understanding how aging cells block muscle repair could lead to new treatments to help older adults stay strong and independent.

This review examines cellular senescence (aging cells that stop dividing) in muscle regeneration, finding that senescent cells play a dual role: they can briefly help repair muscle after injury, but when they accumulate in aging …

Cell regeneration (London, England)
37 Early
Design 4
Sample 2
Peer Review 15
Replication 7
Transparency 9
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Synergistic senolytic-regenerative therapy significantly extends healthspan and lifespan.

BACKGROUND: Current barriers to achieving radical life extension include the inability to use syngeneic, youthful mesenchymal stem cells (MSCs) and the anti-regenerative effects of senescence-associated secretory phenotype (SASP) factors. We aim to overcome this by …

Journal of translational medicine
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

Can we reverse aging by partially reprogramming cells?

This review examines 'partial reprogramming'—a technique that temporarily activates rejuvenation factors to reverse aging hallmarks in cells and tissues without turning them into cancer-prone stem cells. Early evidence suggests it can restore tissue function and …

Trends in molecular medicine
36 Early
Design 4
Sample 2
Peer Review 13
Replication 7
Transparency 10
How we score →
Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Caloric restriction rejuvenates aged adult stem cells: From mechanisms to interventions.

Adult stem cells are essential for maintaining tissue homeostasis and facilitating tissue repair. The ability of aged stem cells to generate functional progeny declines, which is closely associated with the onset and progression of age-related …

Ageing research reviews
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

DNMT3A/TET2-mediated epigenetic alteration in Type-1 diabetes dysregulates the haematopoiesis.

Type 1 diabetes (T1D) is an autoimmune disorder characterized by insulin deficiency and hyperglycemia, driven by environmental insults and epigenetic reprogramming beyond genetic predisposition. Recent evidence suggests that systemic epigenetic dysregulation in T1D influences the …

Molecular biology reports
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other bioRxiv

Targeting therapy-induced senescence across multiple breast cancer subtypes in a metastatic bone-like microenvironment

Chemotherapeutic treatment of breast cancer with Doxorubicin (DOX) can induce tumor and stromal cell senescence leading to therapy-resistance. Senescence-associated secretory phenotype (SASP) promotes secretion of pro-inflammatory and tumorigenic factors causing systemic inflammation. Combined, this can …

biorxiv (preprint)
34 Early
Design 5
Sample 7
Peer Review 4
Replication 6
Transparency 12
How we score →
Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Delayed forebrain excitatory and inhibitory neurogenesis in STRADA-related megalencephaly via mTOR hyperactivity.

Biallelic pathogenic variants in STRADA (STE20-related adaptor alpha), an upstream regulator of the mechanistic target of rapamycin (mTOR) pathway, result in megalencephaly, drug-resistant epilepsy, and severe intellectual disability. This study explores how mTOR pathway hyperactivity …

Stem cell reports
46 Early
Design 5
Sample 7
Peer Review 18
Replication 6
Transparency 10
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Randomized phase 2b dose-escalation trial of stem cell therapy with laromestrocel for aging frailty.

Frailty, a syndrome that decreases healthspan in older individuals, lacks effective therapies. We conducted a randomized, dose-finding clinical trial to test whether human bone marrow-derived allogeneic mesenchymal stem cells (MSCs; laromestrocel) improve physical functioning and …

Cell stem cell
46 Early
Design 5
Sample 7
Peer Review 18
Replication 6
Transparency 10
How we score →
Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Radiotherapy-Induced Skin Fibrosis: Pathophysiology, Emerging Therapeutics, and the Role of Dermatology.

Radiotherapy-induced skin fibrosis is a chronic progressive complication of radiotherapy that impairs function, aesthetics, and quality of life yet remains under-recognized and undertreated. While acute cutaneous toxicities are typically transient, chronic sequelae such as fibrosis, …

American journal of clinical dermatology
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →
Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

Hydrogel-based senomorphic approaches to modulate cellular senescence and promote tissue rejuvenation.

Cellular senescence is a major driver of age-related tissue dysfunction, characterized by chronic inflammation, oxidative stress, mitochondrial impairment, and disrupted extracellular matrix homeostasis. While senolytic strategies that eliminate senescent cells have shown therapeutic promise, irreversible …

Journal of controlled release : official journal of the Controlled Release Society
38 Early
Design 5
Sample 7
Peer Review 10
Replication 6
Transparency 10
How we score →