Stem cell exhaustion, regeneration, and rejuvenation
Frailty, a syndrome that decreases healthspan in older individuals, lacks effective therapies. We conducted a randomized, dose-finding clinical trial to test whether human bone marrow-derived allogeneic mesenchymal stem cells (MSCs; laromestrocel) improve physical functioning and …
Chemoresistance remains the primary cause of cancer treatment failure, yet current understanding remains fragmented across isolated mechanistic studies. This review provides a unified framework linking tumor microenvironment (TME) signaling, epigenetic reprogramming, and nanotherapeutic intervention as …
Biallelic pathogenic variants in STRADA (STE20-related adaptor alpha), an upstream regulator of the mechanistic target of rapamycin (mTOR) pathway, result in megalencephaly, drug-resistant epilepsy, and severe intellectual disability. This study explores how mTOR pathway hyperactivity …
The expanding study of mesenchymal stromal/stem cells (MSC) in cancer has amounted to a growing understanding of their underlying biology in malignant and non-malignant settings. In addition to supporting homeostasis in nearly all normal tissues, …
The bone marrow niche (BMN) plays a central role in regulating hematopoietic stem-cell (HSC) maintenance, lineage commitment, and immune homeostasis, while also supporting osteogenesis and maintaining skeletal integrity. Once considered static, the BMN is now …
Skin aging, the most visible and accessible manifestation of organismal aging, reflects systemic physiological decline, compromising barrier integrity, immune defense, and regenerative capacity-functions essential for overall tissue homeostasis and longevity. Understanding why and how the …
This review examines how immunosenescence (age-related immune decline) drives lung diseases like COPD, fibrosis, and cancer, and surveys emerging treatments including senolytics, stem cell therapy, and lifestyle interventions. While it synthesizes current knowledge well, it's …
Chemotherapeutic treatment of breast cancer with Doxorubicin (DOX) can induce tumor and stromal cell senescence leading to therapy-resistance. Senescence-associated secretory phenotype (SASP) promotes secretion of pro-inflammatory and tumorigenic factors causing systemic inflammation. Combined, this can …
Glioblastoma is a highly aggressive primary brain tumour marked by extensive genomic and epigenomic alterations, cellular heterogeneity, and therapeutic resistance. Despite maximal surgical resection followed by chemoradiotherapy, median survival remains approximately 15 months, reflecting the …
This review examines 'partial reprogramming'—a technique that temporarily activates rejuvenation factors to reverse aging hallmarks in cells and tissues without turning them into cancer-prone stem cells. Early evidence suggests it can restore tissue function and …
Scientists developed a technology that uses electromagnetic fields to remotely activate specific genes in living mice with precise timing and location control. They tested it by partially reversing aging processes, modeling Alzheimer's disease, and treating …
Researchers created a gel containing special vesicles from stem cells that reduces inflammation and cellular aging in aging bone, significantly improving bone and tendon healing in an osteoporosis model. This demonstrates a novel 'senomorphic' approach—directly …
This review examines how blood composition—proteins, metabolites, and cell fragments—both reflects aging and actively drives it across the body. Young blood transferred to older animals reverses some aging markers, suggesting blood-based therapies could become anti-aging …
Researchers discovered that aging planarians (regenerative flatworms) lose fertility not because their stem cells fail, but because their body's positional 'blueprint' gradually shifts out of alignment. By manipulating the molecular signals that control body polarity, …
BACKGROUND: Lower eyelid wrinkles pose a persistent challenge in facial rejuvenation. Layered autologous fat grafting using Coleman fat, SVF-gel, and nanofat offers a regenerative approach with potential synergistic benefits. OBJECTIVE: To assess the efficacy and …
This review examines cellular senescence (aging cells that stop dividing) in muscle regeneration, finding that senescent cells play a dual role: they can briefly help repair muscle after injury, but when they accumulate in aging …
This review challenges the assumption that senescent cells are always harmful, showing that some actually support healthy aging through wound healing and tissue maintenance. The authors propose a new strategy: prevent bad senescence while selectively …
Elastin is a crucial component of elastic fibers, conferring mechanical elasticity and flexibility while facilitating cell interactions within skin tissue, thereby orchestrating the organized structure and damage repair of the extracellular matrix (ECM). Although elastin …
Periodontitis is a chronic inflammatory disease characterized by progressive destruction of periodontal tissues and alveolar bone, traditionally attributed to microbial dysbiosis. Emerging evidence suggests that host-intrinsic factors, including circadian rhythm disruption (CRD) and cellular senescence, …
Radiotherapy-induced skin fibrosis is a chronic progressive complication of radiotherapy that impairs function, aesthetics, and quality of life yet remains under-recognized and undertreated. While acute cutaneous toxicities are typically transient, chronic sequelae such as fibrosis, …