Mitochondria — OutliveHub

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Review / Commentary PubMed

Why Astronauts Are the Perfect Model for Understanding Aging

Understanding how astronauts' bodies age fast in space could reveal new ways to keep older people healthy and strong longer.

Astronauts experience accelerated aging across multiple body systems—heart, muscles, brain, and immune function—due to space environment stressors like microgravity and radiation. This paper argues spaceflight is a uniquely informative human model for studying aging mechanisms …

Nature aging

35 Early

Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary PubMed

Small RNA molecules show promise as aging clocks in blood tests

Scientists may eventually measure your body's true age from a blood test, not just count your birthdays, to guide medical decisions.

This editorial reviews how small noncoding RNAs—particularly piRNAs—circulating in blood could become better measures of biological age than counting birthdays. The authors argue these molecular markers might eventually replace chronological age in medical decisions, but …

Medical science monitor : international medical journal of experimental and clinical research

33 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How worm mitochondria adapt to stress and live longer

Mild stress on cellular power plants may trigger protective cleanup systems that extend lifespan, a mechanism conserved across species.

This review examines how C. elegans worms switch their mitochondrial energy-production machinery to survive low-oxygen or toxic conditions, and how mild damage to this system can actually extend lifespan. The findings suggest conserved cellular stress-response …

Experimental cell research

41 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Epigenetic Drivers of Pulmonary Hypertension: Environment Meets Genome.

Pulmonary hypertension (PH) is a progressive disease in which the pulmonary arteries thicken and narrow, raising pulmonary vascular resistance (PVR) and eventually straining the right ventricle. Known gene mutations explain only a minority of cases …

Cureus

38 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Animal Model bioRxiv

Cutting dietary valine extends male mouse lifespan by 23%

One amino acid in protein might extend male lifespan; needs human testing to know if it matters for you.

Researchers found that lifelong restriction of valine, a branched-chain amino acid in protein, improved metabolic health and reduced aging markers in both male and female mice, but only extended lifespan in males by 23%. The …

biorxiv (preprint)

31 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

A Natural Plant Compound Slows Aging in Worms by Boosting Cellular Cleanup

Researchers found that corylin, a flavonoid from a traditional medicinal plant, extended lifespan and improved stress resistance in C. elegans worms by activating two key proteins that enhance cellular housekeeping and mitochondrial health. While promising, …

Journal of ethnopharmacology

41 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Differential effects of paraquat-induced oxidative stress on functional aging and lifespan in male and female Drosophila melanogaster.

Aging is accompanied by loss of motor function driven by mitochondrial oxidative stress. To examine how genotype and sex modulate this process, we exposed Oregon-R (wild-type) and vestigial (wing-deficient) Drosophila of both sexes to chronic …

PloS one

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Atractylenolide I ameliorates acute-on-chronic liver failure (ACLF) by promoting autophagy and preserving mitochondrial function through mTOR inhibition.

Acute-on-chronic liver failure (ACLF) is a severe liver syndrome marked by systemic inflammation and high mortality, often complicated by autophagy impairment and mitochondrial dysfunction. This study investigates atractylenolide I (AT-1), a compound from Atractylodes macrocephala, …

Biochimica et biophysica acta. Molecular basis of disease

38 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other bioRxiv

Comparative genomics reveals signatures of distinct metabolic strategies and gene loss associated with Hydra immortality

Hydra is a freshwater cnidarian genus that provides a unique comparative model for aging research, contrasting the immortal H. vulgaris with the aging-inducible H. oligactis. Here, we report a high-quality, chromosome-level genome assembly of H. …

biorxiv (preprint)

34 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other PubMed

Universal transcriptomic hallmarks of mammalian ageing and mortality.

Ageing and interventions modulate health and mortality1, yet the underlying molecular mechanisms of this modulation remain unclear. Here we integrate more than 11,000 transcriptomes from more than 25 tissues across 4 mammals (mouse, rat, macaque …

Nature

47 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

Two novel indigenous Levilactobacillus brevis probiotic strains MKMB04 and MKMB05 enhance longevity and protect intestinal barrier function through antioxidant and anti-inflammatory mechanisms.

Aging is characterized by progressive oxidative stress, mitochondrial dysfunction, chronic inflammation and intestinal barrier impairment, contributing to increased susceptibility to age-associated disorders. Targeting redox imbalance and epithelial dysfunction represents a promising therapeutic strategy to promote …

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Review / Commentary PubMed

Can ginseng compounds slow aging? A review of the science and future potential

Ginseng compounds show promise against aging in lab tests, but we lack proof they work in real people yet.

This review examines ginsenosides—compounds from ginseng—and their potential anti-aging effects through mechanisms like reducing cellular stress and supporting mitochondrial health. While promising in laboratory studies, the authors emphasize that moving from bench science to functional …

Critical reviews in food science and nutrition

35 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Review / Commentary PubMed

How Metformin May Slow Aging: Mechanisms and Evidence

Metformin, a cheap diabetes drug, might slow aging, but we need stronger proof before recommending it to everyone.

This review examines how metformin, a common diabetes drug, may have anti-aging properties by activating cellular stress-response pathways (AMPK), reducing inflammation, and improving mitochondrial function. While observational studies and mechanistic evidence are promising, the authors …

Molecular and cellular endocrinology

40 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

How light therapy reverses sun damage by changing skin cell signaling

A light therapy commonly used to reduce wrinkles may work by blocking the cellular damage pathway that sun causes.

Intense pulsed light (IPL)—a common cosmetic treatment—reverses UV sun damage in skin cells by blocking a specific cellular damage pathway (ERK-AP-1-MMP). The study shows this works both in lab-grown human skin cells and in guinea …

Scientific reports

44 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

How a missing immune protein ages the placenta and causes miscarriage

If low IL33 aging placentas triggers miscarriage, drugs that kill senescent cells might prevent pregnancy loss—a major women's health goal.

Researchers found that a protein called IL33 prevents placental aging; when it's missing, the placenta deteriorates through a chain reaction involving lactate buildup and broken autophagy (cellular cleanup). Senescence-targeting drugs like metformin and dasatinib+quercetin restored …

Autophagy

41 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

Mitochondrial Quantity-Quality Imbalance in Cellular Senescence: Practical Readouts and Minimal Assay Bundles.

Cellular senescence is an irreversible program of cell-cycle arrest that accumulates with age, contributing to chronic inflammation and various age-related diseases. A key feature of senescence paradigms is mitochondrial dysfunction, which involves not just a …

BMB reports

38 Early

Disputed Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other medRxiv

Eye fluid reveals mitochondrial damage in vision loss; alpha-ketoglutarate supplement shows promise

Researchers found abnormal mitochondrial function in patients with geographic atrophy (a blinding eye disease) by analyzing fluid from inside the eye. In a small early-stage trial, oral alpha-ketoglutarate supplementation successfully increased the compound's levels in …

medrxiv (preprint)

23 Weak

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other bioRxiv

Hydrogen Peroxide induces resistance to DNA damage in a localization and p53 dependent manner.

Organisms need to be able to adapt to a changing environment in order to survive. The adaptive response invoked by a low dose of a stressor resulting in resistance to high levels of that stressor …

biorxiv (preprint)

34 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Animal Model PubMed

Blood pressure drug losartan rejuvenates aging metabolism in mice and older adults

A common blood pressure drug may slow aging's metabolic clock in older people, though human evidence is still early.

Researchers found that losartan, a common blood pressure medication, shifted the metabolic fingerprint of aged mice and pre-frail older men toward a younger state. The effect appeared dose-dependent in humans and required functional angiotensin II …

Aging cell

47 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Mitochondrial drivers of stem cell aging and inflammaging.

Mitochondria are increasingly recognized as master regulators of aging, integrating bioenergetics, redox control, stem cell fate, and innate immune signaling. This review synthesizes evidence that mitochondrial dysfunction is not only a hallmark but also an …

npj aging

43 Early