Autophagy — OutliveHub

Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

A Protein Called ATG-18 Extends Lifespan Without Needing Its Usual Autophagy Role

Scientists found a longevity protein that works through an unexpected pathway, suggesting new targets for aging drugs.

Researchers discovered that ATG-18, a protein known for triggering cellular cleanup, extends lifespan in worms through a completely different mechanism than expected. The protein interacts with a metabolic enzyme (PCK-2) to relay signals from the …

Aging cell

44 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Other bioRxiv

A role for autophagy of the ER in rejuvenation revealed by microfluidics-based lifespan profiling of yeast gametes

During mitotic growth, Saccharomyces cerevisiae cells age by dividing asymmetrically producing young daughter cells while retaining age-associated damage in the mother cell, which will eventually become senescent. Gametogenesis naturally and completely resets precursor cell lifespan, …

biorxiv (preprint)

34 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

Identification of a conserved receptor for degrading ribosomes through autophagy.

Ribosomes consist of approximately 80 distinct ribosomal proteins and rRNA. The genes encoding these ribosomal components are among the most highly expressed in growing cells. Changes in ribosome composition, such as those induced by oxidative …

Autophagy

38 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How Lysosomes Control Aging: New Pathways to Longer, Healthier Lives

Cells have recycling centers that control aging. Better recycling may slow getting older and prevent age-related diseases.

This review examines how lysosomes—cellular recycling centers—actively regulate aging through two newly discovered signaling pathways (lysosomal surveillance response and transgenerational lysosomal signaling) and the protein TFEB. These findings suggest targeting lysosomal activity could be a …

Ageing research reviews

35 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

Feedback loops between DNMT1 and autophagy as well as senescence promotes organ aging and canities.

Alternations of DNA methylation occur in aging, which is regulated by DNA methyltransferases (DNMTs). In this study, we show that even though the transcription of DNMT1, the only enzyme that maintains DNA methylation in the …

Autophagy

38 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

SUMO protease Pira induces autophagy-related cell death during Drosophila development.

Autophagy is a major intracellular degradative process required for maintaining homeostasis in multicellular organisms. Aberrant autophagy is considered to induce internal environmental disturbance and cell death. Therefore, it is of great significance to explore the …

Genetics

46 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other PubMed

Ginsenoside Rg1 delays chronological aging in a yeast model via SSE1-Mediated mitophagy.

Ginsenoside Rg1 (Rg1), an active compound in Panax ginseng C. A. Meyer (ginseng), has shown potential to ameliorate age-related cell damage and extend lifespan in multiple model organisms. However, the precise molecular mechanisms of its …

Gene

46 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

A Natural Plant Compound Slows Aging in Worms by Boosting Cellular Cleanup

Researchers found that corylin, a flavonoid from a traditional medicinal plant, extended lifespan and improved stress resistance in C. elegans worms by activating two key proteins that enhance cellular housekeeping and mitochondrial health. While promising, …

Journal of ethnopharmacology

41 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

How cells switch off a protective protein under low oxygen to extend life

This helps us understand how cells survive low-oxygen stress, a key process in aging and survival.

Researchers discovered that a protein called Siah-1 acts as a molecular switch under low-oxygen conditions, turning off another protective protein (SKN-1) that would otherwise shorten lifespan in C. elegans worms. This reveals a previously unknown …

Gerontology

42 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How worm mitochondria adapt to stress and live longer

Mild stress on cellular power plants may trigger protective cleanup systems that extend lifespan, a mechanism conserved across species.

This review examines how C. elegans worms switch their mitochondrial energy-production machinery to survive low-oxygen or toxic conditions, and how mild damage to this system can actually extend lifespan. The findings suggest conserved cellular stress-response …

Experimental cell research

41 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Investigating Autophagy Genes Expression and their Possible Relations with ‎Apoptosis in PBMCs of Patients with Thin Endometrium.

BACKGROUND: Autophagy genes are essential for proper uterine function, reproductive physiology, and the maintenance of endometrial atrophy (EA). OBJECTIVE: This study aims to clarify how these genes impact endometrial thickness and their significance in the …

Iranian journal of immunology : IJI

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

mTOR-NAA10-C7orf50 axis senses nutritional status to coordinate ribosome biogenesis and autophagy.

Cellular metabolism is precisely regulated in response to nutrient availability. As an extremely energy-consuming anabolic process, ribosome biogenesis should be tightly controlled in response to nutrient supply. However, how the nucleolus responds to different nutrient …

Science advances

46 Early

Promising Biomarkers — Aging clocks and measurement tools Review / Commentary PubMed

Why centenarians' immune systems stay young

Learning how 100+ year-olds keep strong immune systems could help us stay healthier longer.

Researchers reviewed how people who live to 100+ maintain surprisingly youthful immune function despite extreme age, resisting the chronic inflammation and immune decline that typically accompany aging. They identified several biological mechanisms—including controlled inflammatory pathways, …

Nature reviews. Immunology

51 Promising

Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

A Protein That Shortens Life: Turning Off pitp-1 Extends Healthspan in Worms

Turning off one protein in worm brains extended lifespan and kept muscles stronger longer—a clue to how aging might be controlled.

Researchers found that a protein called pitp-1 acts as a brake on longevity by activating mTOR signaling—a key aging pathway. Disabling pitp-1 in neurons extended lifespan, improved muscle function, and boosted stress resistance in C. …

Journal of biomedical science

44 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

Why Aging Cells Sometimes Help—and Sometimes Hurt—Muscle Repair

Understanding how aging cells block muscle repair could lead to new treatments to help older adults stay strong and independent.

This review examines cellular senescence (aging cells that stop dividing) in muscle regeneration, finding that senescent cells play a dual role: they can briefly help repair muscle after injury, but when they accumulate in aging …

Cell regeneration (London, England)

37 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

Two Repurposed Drugs Trigger Cellular Stress Responses That Extend Lifespan in Worms

Two common drugs might slow aging by triggering cells' defense systems—but we need to test this claim in humans first.

Researchers found that terbinafine (an antifungal) and miglustat (a diabetes drug) activate mitochondrial stress responses that extended lifespan and improved health markers in C. elegans worms and human cells. The discovery suggests these existing drugs …

Aging cell

44 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

How a Traditional Chinese Herb Might Slow Aging Through Immune and Metabolic Pathways

An old herbal remedy may slow aging by tweaking immune and sugar-control systems, but only human studies could prove it helps.

Researchers found that Dendrobium officinale, a traditional longevity herb, extended lifespan in yeast and fruit flies by modulating a key aging-control pathway called PI3K-AKT. Different parts of the plant worked in opposite ways depending on …

Journal of ethnopharmacology

38 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

How mitochondrial hydrogen peroxide can either harm or help cells live longer

Cells may age slower when mildly stressed by hydrogen peroxide, suggesting complete stress elimination isn't ideal for longevity.

Scientists used yeast to show that small amounts of hydrogen peroxide (H2O2) produced in mitochondria trigger protective stress responses and increase lifespan, while large amounts cause damage. This reveals a 'sweet spot' for oxidative stress …

Cell reports

44 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

Rapamycin reduces age-related motor decline in mice, especially in females

Researchers gave aging mice rapamycin and found it prevented the normal decline in movement and motor control, with females benefiting more than males. The benefits appear linked to reduced oxidative stress and cellular stress in …

The journals of gerontology. Series A, Biological sciences and medical sciences

47 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other PubMed

Unveiling the anti-cancer properties of apigenin via targeting different molecular signatures: A Review.

PURPOSE: Apigenin, is a plant derived flavone found in parsley, celery and some spices. It has fascinated a lot of researchers because of its anti-viral, anti-bacterial, anti-inflammatory and above all its anti-cancer abilities. This review …

Molecular biology reports

38 Early