Measures of physiological age distinct from chronological age
OBJECTIVE: To investigate the long-term metabolic and hormonal consequences of sustained weight loss versus weight regain after 1 year of caloric restriction (CR), with attention to insulin resistance and type 2 diabetes risk. RESEARCH DESIGN …
Researchers analyzed 70 lab tests from 300,000 pregnancies and found that pregnancy triggers rapid aging in some systems (coagulation, thyroid, muscle) while rejuvenating others (kidney, iron, liver)—opposite to normal aging patterns. These 'rejuvenation' mechanisms could …
Researchers developed a standardized method to adapt epigenetic aging clocks—which measure biological age through DNA methylation patterns—from older microarray technology to newer sequencing platforms using cell-free DNA. This is important because sequencing is becoming the …
This editorial reviews how small noncoding RNAs—particularly piRNAs—circulating in blood could become better measures of biological age than counting birthdays. The authors argue these molecular markers might eventually replace chronological age in medical decisions, but …
BACKGROUND Little is known about whether epigenetic age acceleration (EAA) clocks are capable of predicting exceptional longevity with or without preserved cognitive function. METHODS We examined 5844 women from the Women's Health Initiative Memory Study. …
Skin aging, the most visible and accessible manifestation of organismal aging, reflects systemic physiological decline, compromising barrier integrity, immune defense, and regenerative capacity-functions essential for overall tissue homeostasis and longevity. Understanding why and how the …
Researchers used artificial intelligence to analyze ECGs and calculate a person's cardiac "biological age"—how old their heart appears versus their calendar age. They found that people whose hearts looked older than they actually were had …
Biological age estimators quantify aging-related variation but provide limited insight into organ-specific aging processes. The retina enables non-invasive visualization of microvascular and neural structures and has emerged as a promising modality for biological age prediction. …
Researchers analyzed DNA methylation patterns in 851 people and found 37 lifestyle, health, and drug factors linked to skin aging—some slowing it down, others speeding it up. Compounds like aspirin and dihydromyricetin showed associations with …
Researchers tested whether dietary changes could shift biological age markers in older adults over 4 weeks. Switching to high-carbohydrate diets or plant-based diets showed improvements in a biological age index, but the authors caution this …
Researchers analyzed sleep duration against 23 biological aging markers across multiple organ systems and found a U-shaped pattern: both too little (<6 hours) and too much (>8 hours) sleep are linked to faster biological aging, …
Researchers developed a new measurement called DISCO that quantifies how disorganized biological systems become with age, using data from multiple large cohorts. They found that this 'entropy' spreads across organ systems rather than occurring in …
Ageing and interventions modulate health and mortality1, yet the underlying molecular mechanisms of this modulation remain unclear. Here we integrate more than 11,000 transcriptomes from more than 25 tissues across 4 mammals (mouse, rat, macaque …
This paper argues that biological aging isn't driven by a single master mechanism, but rather by multiple partially independent processes linked through a network of regulatory hubs. This framework explains why anti-aging treatments typically produce …
Biological ageing begins before birth, with early-life exposures shaping late-life health. These exposures drive health inequities early, yet specific exposures and the composition of the ageing exposome remain largely undefined. This gap may persist as …
Researchers challenged a 150-year-old mathematical model of aging by studying C. elegans worms that live longer than normal. They found that what we thought meant 'slower aging' actually reflects something different: longer periods of frailty …
Epigenetic clocks estimate biological age from DNA methylation patterns at CpG sites, providing robust predictions of mortality and morbidity risk. "Blue zones"--regions of exceptional longevity--offer a unique opportunity to investigate how biological aging diverges from …
Researchers combined six different epigenetic clocks to create a more robust measure of biological aging and tested whether body fat predicts accelerated aging in young Filipino adults. They found consistent links between higher BMI, waist …
Researchers developed an AI model that estimates biological age from retinal photographs and found it correlates strongly with cardiovascular, kidney, and metabolic disease markers in over 30,000 people. This suggests eye imaging could become a …
Over the past decade, ageing clocks have become widely adopted as important tools for understanding biological ageing and have been redefining notions of "pro-longevity" lifestyles. However, this work is still at an early stage. Some …