Aging clocks and measurement tools
The poor prognosis of head and neck squamous cell carcinoma (HNSCC) is primarily attributed to lymphatic or systemic metastasis. The cellular identity plasticity provides carcinocytes with the motility phenotype fluctuations, which indicates the intensified metastasis. …
Human gut Bifidobacteria are abundant during infancy and have been reported to be enriched in some exceptionally long-lived populations, yet whether their beneficial effects on lifespan and healthspan are broadly shared across the genus or …
Background Adverse childhood experiences are associated with reduced healthy longevity, multimorbidity, and chronic pain, but the biological mechanisms involved remain poorly understood. Epigenetic age acceleration (EAA), a DNA methylation marker of biological aging, may represent …
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related deaths worldwide, highlighting the urgent requirement for innovative therapeutic strategies. Cytisine N-methylene-(4',5,7-trihydroxy)-isoflavone (named CNI3), a natural derivative of cytisine N-isoflavone isolated from Sophora alopecuroides …
AIMS: Following Italy's psychiatric reform, national inpatient numbers declined, but how the age at admission has changed across sex, diagnostic, and admission-type subgroups remains unclear. This study examined 17 consecutive years (2006-2022) of psychiatric admissions …
The management of metastatic castration-resistant prostate cancer (mCRPC) is continuously challenged by the emergence of therapeutic resistance. Under the selective pressure of profound androgen inhibition, a significant proportion of tumors undergo lineage plasticity, evolving into …
BACKGROUND: Little is known about whether epigenetic age acceleration (EAA) clocks are capable of predicting exceptional longevity with or without preserved cognitive function. METHODS: We examined 5844 women from the Women's Health Initiative Memory Study. …
Hydra is a freshwater cnidarian genus that provides a unique comparative model for aging research, contrasting the immortal H. vulgaris with the aging-inducible H. oligactis. Here, we report a high-quality, chromosome-level genome assembly of H. …
B‑cell receptor (BCR) signaling is essential for the survival and proliferation of normal B cells, and contributes substantially to the pathogenesis of diffuse large B‑cell lymphoma (DLBCL). Bruton's tyrosine kinase (BTK), a key downstream component …
Anxiety disorders and posttraumatic stress disorder (PTSD) often occur alongside signs of accelerated biological aging, yet the molecular pathways that connect genetic liability to synaptic and circuit-level dysfunction remain unclear. We performed a multi-gene-set transcriptome-wide …
Researchers tested 16 different biomarkers of aging (epigenetic clocks, blood proteins, telomeres, and others) in over 1,000 people tracked for 7 years. Two markers—Allostatic Load Index and DunedinPACE—stood out as the most reliable predictors of …
This review synthesizes evidence that natural killer (NK) cells—a type of immune cell—undergo age-related changes that impair their ability to clear damaged cells and regulate inflammation, contributing to aging-related diseases. The authors propose NK cell …
Researchers created a miniature laboratory system using human stem cells that reproduces aging hallmarks in just 4 days—a process that normally takes decades. This 'aging-on-a-chip' could accelerate testing of anti-aging therapies and reveal how rejuvenation …
Researchers tested whether dietary changes could shift biological age markers in older adults over 4 weeks. Switching to high-carbohydrate diets or plant-based diets showed improvements in a biological age index, but the authors caution this …
BACKGROUND Little is known about whether epigenetic age acceleration (EAA) clocks are capable of predicting exceptional longevity with or without preserved cognitive function. METHODS We examined 5844 women from the Women's Health Initiative Memory Study. …
A growing body of evidence supports the role of nutrient sensing and metabolism pathways in regulating ageing rate and healthspan, but the diversity of human lifestyles challenges our ability to identify the mechanisms of this …
Pulmonary tuberculosis (TB) exhibits marked spatial heterogeneity, with alveolar pneumonia and organized granulomas frequently coexisting within the same lung. While granulomas have long dominated conceptual models of TB pathogenesis, the immune programs operating within alveolar …
Physical exercise is a potent modifier of CNS aging, but its relationship with the cyclin-dependent kinase inhibitor p21 (CDKN1A) is neither uniformly suppressive nor equivalent to cellular senescence. Direct evidence remains sparse and preclinical. Sustained …
A dual-crosslinked gelatin-hyaluronic acid (HA) film loaded with perilla essential oil was developed for Actinidia arguta preservation. Ca2+ and gallic acid reinforced the film network, giving GH/Ca/A₃ high tensile strength (40.39 MPa), low water vapor …
This study aimed to investigate the metabolic mechanisms and identify potential biomarkers of resilience and longevity by comparing divergent functional longevity lines and phenotypic resilience groups in dairy goats. A total of 70 Alpine goats, …