Aging clocks and measurement tools
Stressful life events (SLEs) are associated with increased risk of psychiatric and somatic disease, yet the molecular correlates of stress exposure across time remain incompletely characterised. We conducted a multi-omic analysis in the Finnish Twin …
Researchers compared DNA methylation aging clocks across three tissue types (saliva, blood cells, and immune cells) in 91 young adults and found that saliva shows different aging patterns than blood, though blood-based samples are interchangeable …
Skin aging, the most visible and accessible manifestation of organismal aging, reflects systemic physiological decline, compromising barrier integrity, immune defense, and regenerative capacity-functions essential for overall tissue homeostasis and longevity. Understanding why and how the …
Researchers developed an improved method (FAβ-gal) to detect and quantify senescent cells—aging cells that stop dividing—using existing lab equipment. The new approach is faster, more accurate, and less subjective than the current gold-standard test, potentially …
BACKGROUND/OBJECTIVE: Sepsis remains a leading cause of mortality worldwide, with immune dysfunction serving as a central driver of adverse outcomes. While early hyperinflammation contributes to organ damage, subsequent immunoparalysis characterized by T-cell exhaustion, monocyte deactivation, …
Researchers conducted an intensive year-long self-study (N=1) combining time-restricted eating, exercise, Mediterranean diet, and continuous biomarker monitoring to assess how well a healthy person's body adapts to stress. The study demonstrates new methods for tracking …
Researchers analyzed blood chemistry in 213 people over 100 years old and found they have distinctly different metabolic profiles—especially higher bile acids and lower inflammatory markers—compared to younger controls. By identifying these metabolic signatures, they …
Researchers used AI to estimate cardiovascular 'biological age' from simple heart ultrasounds in 243 adults. People whose heart appeared older than their calendar age had worse metabolic health markers and were twice as likely to …
Researchers tested 16 different biomarkers of aging (epigenetic clocks, blood proteins, telomeres, and others) in over 1,000 people tracked for 7 years. Two markers—Allostatic Load Index and DunedinPACE—stood out as the most reliable predictors of …
A growing body of evidence supports the role of nutrient sensing and metabolism pathways in regulating ageing rate and healthspan, but the diversity of human lifestyles challenges our ability to identify the mechanisms of this …
Hydra is a freshwater cnidarian genus that provides a unique comparative model for aging research, contrasting the immortal H. vulgaris with the aging-inducible H. oligactis. Here, we report a high-quality, chromosome-level genome assembly of H. …
This review synthesizes evidence that natural killer (NK) cells—a type of immune cell—undergo age-related changes that impair their ability to clear damaged cells and regulate inflammation, contributing to aging-related diseases. The authors propose NK cell …
Researchers created a miniature laboratory system using human stem cells that reproduces aging hallmarks in just 4 days—a process that normally takes decades. This 'aging-on-a-chip' could accelerate testing of anti-aging therapies and reveal how rejuvenation …
Chronic atrophic gastritis (CAG) is a critical precancerous condition with limited therapeutic options to halt its progression toward gastric cancer. Targeting dysregulated metabolism and inflammation-driven transformation represents a promising yet underexplored strategy. Herein, through systematic …
Researchers tested whether dietary changes could shift biological age markers in older adults over 4 weeks. Switching to high-carbohydrate diets or plant-based diets showed improvements in a biological age index, but the authors caution this …
BACKGROUND Little is known about whether epigenetic age acceleration (EAA) clocks are capable of predicting exceptional longevity with or without preserved cognitive function. METHODS We examined 5844 women from the Women's Health Initiative Memory Study. …
Ageing and interventions modulate health and mortality1, yet the underlying molecular mechanisms of this modulation remain unclear. Here we integrate more than 11,000 transcriptomes from more than 25 tissues across 4 mammals (mouse, rat, macaque …
Pulmonary tuberculosis (TB) exhibits marked spatial heterogeneity, with alveolar pneumonia and organized granulomas frequently coexisting within the same lung. While granulomas have long dominated conceptual models of TB pathogenesis, the immune programs operating within alveolar …
Researchers tracked 247 cognitively healthy centenarians and found that GrimAge—a DNA methylation-based "biological clock"—strongly predicted who would die sooner, independent of cognitive decline or brain biomarkers. This suggests aging in the blood may be a …
This study aimed to investigate the metabolic mechanisms and identify potential biomarkers of resilience and longevity by comparing divergent functional longevity lines and phenotypic resilience groups in dairy goats. A total of 70 Alpine goats, …