DNA methylation-based age estimation and age acceleration
Ageing and interventions modulate health and mortality1, yet the underlying molecular mechanisms of this modulation remain unclear. Here we integrate more than 11,000 transcriptomes from more than 25 tissues across 4 mammals (mouse, rat, macaque …
This review argues that combining topical skin treatments (retinoids, peptides, antioxidants) with internal supplements (NAD+ precursors, collagen peptides, polyphenols) can target multiple aging mechanisms simultaneously. While conceptually sound, the paper is a narrative review without …
Researchers applied a quinoa-based product to women's skin and used machine learning to analyze protein changes, finding that treated skin showed molecular signatures resembling younger skin—with predicted age reductions of 11–16 years depending on age …
Researchers challenged a 150-year-old mathematical model of aging by studying C. elegans worms that live longer than normal. They found that what we thought meant 'slower aging' actually reflects something different: longer periods of frailty …
Researchers found that skin aging leaves measurable epigenetic fingerprints that are consistent across different ethnic groups and skin types. A topical serum containing dihydromyricetin reduced these aging marks in a 60-person clinical trial, with visible …
Living in economically disadvantaged neighborhoods is associated with accelerated epigenetic aging—a molecular measure of biological age—even after accounting for individual health factors. The link appears partly explained by cumulative stress and life adversity, with stronger …
Reprogramming-induced rejuvenation (RIR) reverses cellular aging by transiently engaging early reprogramming states without full dedifferentiation. This review examines current developments in the molecular mechanisms, technological advances, and tissue-specific applications of RIR. Recent mechanistic insights highlight …
Stressful life events (SLEs) are associated with increased risk of psychiatric and somatic disease, yet the molecular correlates of stress exposure across time remain incompletely characterised. We conducted a multi-omic analysis in the Finnish Twin …
Researchers analyzed 70 lab tests from 300,000 pregnancies and found that pregnancy triggers rapid aging in some systems (coagulation, thyroid, muscle) while rejuvenating others (kidney, iron, liver)—opposite to normal aging patterns. These 'rejuvenation' mechanisms could …
A small clinical trial found that bezisterim, an experimental anti-inflammatory drug, reduced epigenetic markers of aging and was associated with changes in genes linked to brain inflammation and cognitive decline. However, this is early-stage work …
Researchers developed OMICmAge, a biological age measure combining DNA methylation, proteins, and metabolites that predicts mortality and chronic disease better than existing aging clocks. Tested across ~36,000 people, it could become a scalable clinical tool …
Epigenetic clocks estimate biological age from DNA methylation patterns at CpG sites, providing robust predictions of mortality and morbidity risk. "Blue zones"--regions of exceptional longevity--offer a unique opportunity to investigate how biological aging diverges from …
Biological ageing begins before birth, with early-life exposures shaping late-life health. These exposures drive health inequities early, yet specific exposures and the composition of the ageing exposome remain largely undefined. This gap may persist as …
Age-related circadian disruptions accelerate physiological decline and shorten lifespan. Enhancing circadian amplitude has emerged as a promising strategy for ameliorating age-associated disorders. Here, we show that the circadian-phase-optimized administration of 3'-deoxyadenosine (3dA) strengthens circadian amplitude …
Ambient air pollution has been associated with increased incidence of chronic disease and is estimated to contribute towards 4.2 million early deaths annually. Whilst the health impacts are well described, less is understood about the …
Over the past decade, ageing clocks have become widely adopted as important tools for understanding biological ageing and have been redefining notions of "pro-longevity" lifestyles. However, this work is still at an early stage. Some …
A growing body of evidence supports the role of nutrient sensing and metabolism pathways in regulating ageing rate and healthspan, but the diversity of human lifestyles challenges our ability to identify the mechanisms of this …
Ageing biomarkers can predict mortality risk beyond chronological age. Recently, plasma proteins were used to estimate the biological ages of eleven human organs, including the brain, heart, liver, kidneys, and pancreas. Accelerated organ ageing is …
Epigenetic clocks derived from DNA methylation patterns are among the most promising biomarkers of biological aging1-7, as they capture molecular signatures that predict morbidity and mortality beyond chronological age. Although cross-sectional assessments of epigenetic age …
BACKGROUND Little is known about whether epigenetic age acceleration (EAA) clocks are capable of predicting exceptional longevity with or without preserved cognitive function. METHODS We examined 5844 women from the Women's Health Initiative Memory Study. …