BACKGROUND: Chronic psychological stress is a well-recognized factor in the exacerbation of allergic diseases, with IgE playing a central role in their pathophysiology. However, the exact molecular mechanisms by which stress hormones directly influence IgE …
Researchers tested whether dietary changes could shift biological age markers in older adults over 4 weeks. Switching to high-carbohydrate diets or plant-based diets showed improvements in a biological age index, but the authors caution this …
The eyes and facial skin play a crucial role in preserving a youthful appearance; they greatly impact the perception of freshness and vitality. Various non-invasive and invasive procedures now treat dermatochalasis and facial wrinkles, including …
Changes in peripheral CD8+ T cells are a hallmark of immune aging. However, the role of aged non-infiltrating CD8+ T cells in brain aging remains to be fully defined. Here, we showed that aged circulating …
BackgroundWhile immunologic aging impacts immune responses to vaccination, consistent biomarkers associated with aging of the immune system and suboptimal serologic response to influenza vaccination have not been well-studied. Identification of readily measurable biomarkers of immunosenescence …
BACKGROUND: People with HIV (PWH) experience chronic inflammation and more age-related comorbidities despite antiretroviral therapy (ART). Classical senescence biomarkers (e.g., SA-βGal, p16INK4a, γH2AX and Bcl-2) and senescence-associated secretory phenotype (SASP) factors such as IL-6 reflect …
BACKGROUND: Platelet-rich plasma (PRP) is used as an adjunctive treatment in various medical fields, including orthopaedics, plastic surgery, dermatology, and wound healing. However, PRP application in reproductive medicine, particularly for fertility restoration, remains controversial, specifically …
Researchers tested injectable forms of nicotinamide riboside (NR), a compound that boosts NAD+ levels, in two small Phase 1 trials with 84 total participants. The injections were well-tolerated with no serious safety concerns, though some …
A major clinical trial tracked 864 different metabolites in people doing long-term caloric restriction and found distinct shifts in carbohydrate and fat metabolism—with early changes during weight loss giving way to compensatory responses during weight …
Researchers created LongevityBench, a standardized test to evaluate whether large language models (LLMs) can accurately interpret aging biology and predict age-related outcomes from biodata. The benchmark spans human lifespan prediction, genetic effects, and multiple data …
This review examines how blood composition—proteins, metabolites, and cell fragments—both reflects aging and actively drives it across the body. Young blood transferred to older animals reverses some aging markers, suggesting blood-based therapies could become anti-aging …
Researchers studied over 420 long-lived families across three generations and found that people who inherit fewer genetic risk factors for heart disease—particularly genes affecting cholesterol—tend to live longer and healthier lives. This suggests that staying …
The prevalence of major depressive disorder (MDD) is increasing globally, particularly among adolescents. Although gut-brain axis dysfunction has been implicated in adolescent depression, the mechanisms by which gut microbiota dysbiosis drives depressive behaviors and potential …
Micro- and nanoplastics (MNPs) are emerging environmental contaminants with ubiquitous distribution and growing concern for reproductive health. Recent detection of MNPs in human follicular fluid and seminal plasma suggests that these particles can enter the …
Plasma biomarkers of Alzheimers pathology have been studied in relation to cognitive decline and dementia, but no prior study has examined their associations with longevity or healthspan. In this cohort study of older women (N=2,576), …
This review examines how metformin, a common diabetes drug, may have anti-aging properties by activating cellular stress-response pathways (AMPK), reducing inflammation, and improving mitochondrial function. While observational studies and mechanistic evidence are promising, the authors …
Researchers developed an AI model that estimates biological age from retinal photographs and found it correlates strongly with cardiovascular, kidney, and metabolic disease markers in over 30,000 people. This suggests eye imaging could become a …
Researchers analyzed 70 lab tests from 300,000 pregnancies and found that pregnancy triggers rapid aging in some systems (coagulation, thyroid, muscle) while rejuvenating others (kidney, iron, liver)—opposite to normal aging patterns. These 'rejuvenation' mechanisms could …
Researchers found that losartan, a common blood pressure medication, shifted the metabolic fingerprint of aged mice and pre-frail older men toward a younger state. The effect appeared dose-dependent in humans and required functional angiotensin II …
This review examines whether infusing young plasma can rejuvenate aging bodies, a concept supported by animal experiments but largely unproven in humans. The authors argue that while preclinical models show promise, current clinical applications of …