A major clinical trial tracked 864 different metabolites in people doing long-term caloric restriction and found distinct shifts in carbohydrate and fat metabolism—with early changes during weight loss giving way to compensatory responses during weight …
Researchers analyzed 70 lab tests from 300,000 pregnancies and found that pregnancy triggers rapid aging in some systems (coagulation, thyroid, muscle) while rejuvenating others (kidney, iron, liver)—opposite to normal aging patterns. These 'rejuvenation' mechanisms could …
BackgroundWhile immunologic aging impacts immune responses to vaccination, consistent biomarkers associated with aging of the immune system and suboptimal serologic response to influenza vaccination have not been well-studied. Identification of readily measurable biomarkers of immunosenescence …
BACKGROUND: Platelet-rich plasma (PRP) is used as an adjunctive treatment in various medical fields, including orthopaedics, plastic surgery, dermatology, and wound healing. However, PRP application in reproductive medicine, particularly for fertility restoration, remains controversial, specifically …
Inflammatory microenvironments regulate immune cell differentiation, activation, and programming. Although traditionally considered terminally differentiated effectors, neutrophils can acquire distinct functional states in response to environmental cues. To examine context-dependent neutrophil programming, cells from healthy donors …
Researchers developed an AI model that estimates biological age from retinal photographs and found it correlates strongly with cardiovascular, kidney, and metabolic disease markers in over 30,000 people. This suggests eye imaging could become a …
This review examines how blood composition—proteins, metabolites, and cell fragments—both reflects aging and actively drives it across the body. Young blood transferred to older animals reverses some aging markers, suggesting blood-based therapies could become anti-aging …
BACKGROUND: People with HIV (PWH) experience chronic inflammation and more age-related comorbidities despite antiretroviral therapy (ART). Classical senescence biomarkers (e.g., SA-βGal, p16INK4a, γH2AX and Bcl-2) and senescence-associated secretory phenotype (SASP) factors such as IL-6 reflect …
BACKGROUND: Over Earth's history, the Sun has continuously released coronal mass ejections of plasma that have flowed toward Earth, generating the need for reactive oxygen and nitrogen species (RONS) for plants. On the other hand, …
Plasma biomarkers of Alzheimers pathology have been studied in relation to cognitive decline and dementia, but no prior study has examined their associations with longevity or healthspan. In this cohort study of older women (N=2,576), …
Researchers tested injectable forms of nicotinamide riboside (NR), a compound that boosts NAD+ levels, in two small Phase 1 trials with 84 total participants. The injections were well-tolerated with no serious safety concerns, though some …
Our previous work revealed differences in conventional lipid parameters between individuals from the Bama longevity hotspot and general population controls. However, their comprehensive atherogenic risk profile, as assessed by novel composite indices, remains uncharacterized. This …
Objectives: Rheumatoid arthritis (RA) synovitis frequently persists despite cytokine-targeted therapies, suggesting the existence of pathogenic stromal programs that sustain chronic inflammation independently of canonical immune pathways. Although synovial fibroblasts (SF) are increasingly implicated in treatment …
This review examines how metformin, a common diabetes drug, may have anti-aging properties by activating cellular stress-response pathways (AMPK), reducing inflammation, and improving mitochondrial function. While observational studies and mechanistic evidence are promising, the authors …
Researchers studied over 420 long-lived families across three generations and found that people who inherit fewer genetic risk factors for heart disease—particularly genes affecting cholesterol—tend to live longer and healthier lives. This suggests that staying …
The prevalence of major depressive disorder (MDD) is increasing globally, particularly among adolescents. Although gut-brain axis dysfunction has been implicated in adolescent depression, the mechanisms by which gut microbiota dysbiosis drives depressive behaviors and potential …
INTRODUCTION: Facial rejuvenation increasingly uses techniques targeting the Superficial Muscular Aponeurotic System (SMAS) for natural, durable results. Advances in anesthesia, especially tumescent local anesthesia (TLA), have enhanced the safety and recovery of complex aesthetic procedures. …
Multiple myeloma (MM) is a malignant plasma cell disorder characterized by clonal expansion of plasma cells in bone marrow. Genetic aberrations in MM are well‑established, while epigenetic alterations, particularly DNA methylation, are increasingly recognized as …
Micro- and nanoplastics (MNPs) are emerging environmental contaminants with ubiquitous distribution and growing concern for reproductive health. Recent detection of MNPs in human follicular fluid and seminal plasma suggests that these particles can enter the …
Researchers found that losartan, a common blood pressure medication, shifted the metabolic fingerprint of aged mice and pre-frail older men toward a younger state. The effect appeared dose-dependent in humans and required functional angiotensin II …