Omics — OutliveHub

Preliminary Biomarkers — Aging clocks and measurement tools Observational medRxiv

Aging May Be a Spreading Disorder of System-Wide Coordination

If this holds up, we may have a better way to measure your body's aging and spot problems early—by checking how well your organ systems still talk to each other.

Researchers developed a new measurement called DISCO that quantifies how disorganized biological systems become with age, using data from multiple large cohorts. They found that this 'entropy' spreads across organ systems rather than occurring in …

medrxiv (preprint)

37 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other PubMed

Artificial intelligence across the aging continuum: mechanistic geroscience, therapeutic innovation, and clinical impact.

Aging emerges from nonlinear interactions among primary, antagonistic, and integrative hallmarks that progressively erode tissue resilience. As global demographics shift and chronic disease burden intensifies, extending healthspan with mechanistic precision has become imperative, accelerating the …

Ageing research reviews

38 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Observational medRxiv

The Sleep Sweet Spot: How 6–8 hours connects to biological aging across your whole body

Researchers analyzed sleep duration against 23 biological aging markers across multiple organ systems and found a U-shaped pattern: both too little (<6 hours) and too much (>8 hours) sleep are linked to faster biological aging, …

medrxiv (preprint)

39 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other PubMed

Estropausal gut microbiota transplant improves measures of ovarian function in adult mice.

The decline in ovarian function with age affects fertility and is associated with increased risk of age-related diseases, including osteoporosis and dementia. Notably, earlier menopause is linked to shorter lifespan, yet the molecular mechanisms underlying …

Nature aging

47 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

From complexity to clarity: aging bone marrow niche in bone and blood regeneration and malignancy.

The bone marrow niche (BMN) plays a central role in regulating hematopoietic stem-cell (HSC) maintenance, lineage commitment, and immune homeostasis, while also supporting osteogenesis and maintaining skeletal integrity. Once considered static, the BMN is now …

Bone research

38 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Epigenetic Information Loss and Chronosenescence in Liver Aging: From Molecular Mechanisms to Therapeutic Interventions.

Liver aging involves progressive functional decline and increased susceptibility to metabolic diseases. Emerging evidence supports the view that some aspects of liver aging reflect partially reversible disruption of epigenetic and circadian regulatory programs, rather than …

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

38 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Review / Commentary PubMed

How aging immune systems damage lungs—and what treatments might help

If your immune system ages slower, your lungs might stay healthier longer—but we need better treatments to prove it works.

This review examines how immunosenescence (age-related immune decline) drives lung diseases like COPD, fibrosis, and cancer, and surveys emerging treatments including senolytics, stem cell therapy, and lifestyle interventions. While it synthesizes current knowledge well, it's …

BMC medicine

36 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Cohort Study medRxiv

How Caloric Restriction Reshapes Your Metabolism Over 2 Years

A major clinical trial tracked 864 different metabolites in people doing long-term caloric restriction and found distinct shifts in carbohydrate and fat metabolism—with early changes during weight loss giving way to compensatory responses during weight …

medrxiv (preprint)

39 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Divergent molecular strategies underlie bovine blastocyst hatching and cryopreservation stress adaptation revealed by integrated multi-omics.

Cryopreservation tolerance and blastocyst hatching are two major challenges for successful embryo transfer. Whether embryos employ distinct molecular strategies to navigate programmed developmental transitions versus acute environmental stress remains unclear. To address this, we performed …

Theriogenology

38 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other PubMed

Mechanisms of postpartum metabolic dysfunction-associated steatotic liver disease in women with a history of gestational diabetes mellitus.

ABSTRACT: Gestational diabetes mellitus (GDM) is a rapidly increasing global health challenge that is closely linked to the rising rates of obesity and type 2 diabetes mellitus. Similarly, metabolic dysfunction-associated steatotic liver disease (MASLD) has …

Endocrine connections

38 Early

Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary PubMed

Blood as a window and tool for reversing aging: what recent research reveals

Blood might reveal how fast you're aging and could be used to treat aging itself—but human evidence is still early.

This review examines how blood composition—proteins, metabolites, and cell fragments—both reflects aging and actively drives it across the body. Young blood transferred to older animals reverses some aging markers, suggesting blood-based therapies could become anti-aging …

Experimental & molecular medicine

40 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Dose-Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload.

Iron overload induces cellular stress and is implicated in diverse pathological conditions. Nevertheless, the epigenetic mechanisms governing mammalian cellular responses to iron overload remain poorly characterized. Using multi-omics profiling in human granulosa cells, we show …

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

46 Early

Promising Biomarkers — Aging clocks and measurement tools Review / Commentary PubMed

Why centenarians' immune systems stay young

Learning how 100+ year-olds keep strong immune systems could help us stay healthier longer.

Researchers reviewed how people who live to 100+ maintain surprisingly youthful immune function despite extreme age, resisting the chronic inflammation and immune decline that typically accompany aging. They identified several biological mechanisms—including controlled inflammatory pathways, …

Nature reviews. Immunology

51 Promising

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

ENO1 couples HDAC1 to regulate histone lactylation and gene transcription.

Histone deacetylases (HDACs) regulate transcription and catalyze deacetylation predominantly within canonical transcriptional complexes. Nevertheless, the mechanistic role of other HDAC-associated proteins in orchestrating this process remains incompletely understood. To systematically decode endogenous HDAC interactomes in …

Proceedings of the National Academy of Sciences of the United States of America

46 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other PubMed

MNS induces antiviral protection and suppresses inflammation.

BACKGROUND: Identifying safe and broad-spectrum antiviral and anti-inflammatory agents remains an urgent need in infectious and inflammatory diseases. Here, we demonstrated that MNS (NSC170724), a small-molecule nitrovinyl benzodioxole, enhanced antiviral defense while limiting excessive inflammation. …

Annals of medicine

38 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other bioRxiv

Colchicine Directly Targets Aldehyde Dehydrogenase 2 (ALDH2) to Suppress Radiation-Induced Senescence and Atherosclerosis

Background: Ionizing radiation (IR) accelerates atherosclerosis through induction of cellular senescence, DNA damage, defective efferocytosis, and dysregulation of clonal hematopoiesis (CH) drivers. Although low-dose colchicine reduces ischemic cardiovascular events in coronary artery disease, the precise …

biorxiv (preprint)

34 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other medRxiv

Multi-omics of stressful life events

Stressful life events (SLEs) are associated with increased risk of psychiatric and somatic disease, yet the molecular correlates of stress exposure across time remain incompletely characterised. We conducted a multi-omic analysis in the Finnish Twin …

medrxiv (preprint)

34 Early

Preliminary Biomarkers — Aging clocks and measurement tools Observational PubMed

Gut Bacteria Linked to Living Past 90: What Their Microbiomes Reveal

Researchers compared gut bacteria in people aged 45–59, 60–89, and 90+ and found that centenarians have distinctly different microbial communities—richer in beneficial bacteria like Akkermansia and enriched in pathways that produce fatty acids and other …

Applied microbiology and biotechnology

44 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

A Protein Called ATG-18 Extends Lifespan Without Needing Its Usual Autophagy Role

Scientists found a longevity protein that works through an unexpected pathway, suggesting new targets for aging drugs.

Researchers discovered that ATG-18, a protein known for triggering cellular cleanup, extends lifespan in worms through a completely different mechanism than expected. The protein interacts with a metabolic enzyme (PCK-2) to relay signals from the …

Aging cell

44 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other PubMed

Evolutionary genetics of ageing.

Modern humans now routinely survive to advanced ages, in far greater proportions than ancestral populations, and thus experience the consequences of molecular pathways optimized for youth yet still active in old age. Natural selection weakens …

Nature reviews. Genetics

46 Early