Molecular markers that predict biological age and healthspan
Researchers found abnormal mitochondrial function in patients with geographic atrophy (a blinding eye disease) by analyzing fluid from inside the eye. In a small early-stage trial, oral alpha-ketoglutarate supplementation successfully increased the compound's levels in …
Researchers discovered that aging pancreas alpha cells trigger inflammatory immune responses linked to type 2 diabetes. In mice, calorie restriction reversed this inflammation by reducing immune cell recruitment to the pancreas. This suggests a new …
Researchers developed a standardized method to adapt epigenetic aging clocks—which measure biological age through DNA methylation patterns—from older microarray technology to newer sequencing platforms using cell-free DNA. This is important because sequencing is becoming the …
Researchers found that coordinated control of proteasome subunit genes—the cellular recycling machinery—is critical for longevity in C. elegans. When this coordination breaks down, even genetic interventions that normally extend lifespan fail, suggesting proteostasis balance is …
Researchers developed a new tool to watch autophagy (cellular recycling) in real time in naked mole-rat cells and discovered that these long-lived animals respond to stress by forming temporary vacuoles—a protective response that reverses when …
Researchers developed an AI model that estimates biological age from retinal photographs and found it correlates strongly with cardiovascular, kidney, and metabolic disease markers in over 30,000 people. This suggests eye imaging could become a …
Epigenetic clocks estimate biological age from DNA methylation patterns at CpG sites, providing robust predictions of mortality and morbidity risk. "Blue zones"--regions of exceptional longevity--offer a unique opportunity to investigate how biological aging diverges from …
Researchers found that boosting adrenaline-like signaling in the gut of female fruit flies extends their lifespan by activating a specific protein called CrebB. This suggests that neuroendocrine pathways—which are conserved across animals—might be a viable …
Researchers treated female mice with fatty liver disease (MASLD) using senolytic drugs—compounds that eliminate senescent (aged) cells—and found pregnancy rates improved, particularly through reduced aging and inflammation in the ovaries. However, the treatment had limited …
This review examines how chemical modifications to RNA molecules regulate telomere maintenance—the process that prevents chromosome shortening and cellular aging. The authors propose that understanding these epitranscriptomic controls could reveal new targets for treating aging-related …
Researchers isolated five previously unknown alkaloid compounds from a plant called Benstonea parva and tested them in C. elegans worms. Four of the compounds extended lifespan by up to 9%, suggesting these plant molecules may …
Aging of hematopoietic stem and progenitor cells (HSPCs) impairs regenerative capacity and predisposes to hematological diseases. Here, we constructed a comprehensive single-cell transcriptomic atlas comprising 186,123 CD34+ HSPCs spanning early prenatal development (6 post-conception weeks) …
A major clinical trial tracked 864 different metabolites in people doing long-term caloric restriction and found distinct shifts in carbohydrate and fat metabolism—with early changes during weight loss giving way to compensatory responses during weight …
Researchers mapped the proteins in immortal jellyfish (Turritopsis) that detect environmental stress and decide whether to stay dormant or regenerate. They identified a three-layer signaling architecture centered on mTORC1—a key aging pathway—that could offer clues …
Biological age estimators quantify aging-related variation but provide limited insight into organ-specific aging processes. The retina enables non-invasive visualization of microvascular and neural structures and has emerged as a promising modality for biological age prediction. …
Biological ageing begins before birth, with early-life exposures shaping late-life health. These exposures drive health inequities early, yet specific exposures and the composition of the ageing exposome remain largely undefined. This gap may persist as …
This review synthesizes evidence that natural killer (NK) cells—a type of immune cell—undergo age-related changes that impair their ability to clear damaged cells and regulate inflammation, contributing to aging-related diseases. The authors propose NK cell …
Researchers analyzed sleep duration against 23 biological aging markers across multiple organ systems and found a U-shaped pattern: both too little (<6 hours) and too much (>8 hours) sleep are linked to faster biological aging, …
Researchers studied 3,703 adults over 90 and 22,354 younger adults to identify genetic variants linked not just to living longer, but to living longer *well*. They found that certain genes (APOE, APOC1) are associated with …
A protein called klotho, known to extend lifespan and boost brain function, appears to protect people with Parkinson's disease from cognitive decline—at least in genetic studies and mouse models. Researchers found that higher klotho levels …