Genetics & Genomics — OutliveHub

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Animal Model bioRxiv

How Genes Control Muscle's Role in Heart and Lung Fitness

Understanding genes that control fitness could help doctors design treatments to protect the heart and extend lifespan.

Researchers studied rats bred for high and low running capacity and found that genes controlling muscle enhancers—regulatory DNA regions—drive differences in cardiorespiratory fitness by reshaping how cells handle energy and oxygen. This molecular map could …

biorxiv (preprint)

34 Early

Promising Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Cohort Study PubMed

Why Some Families Stay Healthy Into Old Age: The Role of 'Good' Genes

Your genes influence how long you stay healthy, especially genes controlling cholesterol and heart disease risk.

Researchers studied over 420 long-lived families across three generations and found that people who inherit fewer genetic risk factors for heart disease—particularly genes affecting cholesterol—tend to live longer and healthier lives. This suggests that staying …

GeroScience

58 Promising

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

Economic modeling and selection for longevity traits in dairy cattle.

Different definitions have been proposed for longevity, making it challenging to compare methods for estimating the economic significance of survival traits. Simple profit functions often fail to capture biological complexity, whereas bioeconomic models, though comprehensive, …

The Journal of dairy research

38 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

The evolution of aging research: from theories to epigenetic reprogramming.

Over the past decades, numerous studies aimed to discover the fundamental cause of the aging process. Rather than a single root cause, multiple factors were identified, suggesting that aging manifests itself through a progressive degradation …

npj aging

43 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

Aspartame enhances innate immunity and extends lifespan in Caenorhabditis elegans via autophagy pathway.

Aspartame (ASP) is a common artificial sweetener used in food and beverages. There is currently significant controversy surrounding the safety of aspartame. However, the molecular mechanisms of aspartame on innate immunity and lifespan remain poorly …

Food research international (Ottawa, Ont.)

38 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

Loss of Echs1 in neural stem and progenitor cells impairs neurogenesis via ER stress activation and lipid metabolic reprogramming.

Mitochondrial short-chain enoyl-CoA hydratase 1 deficiency (ECHS1D) is a rare and severe encephalopathy linked to neurodevelopmental disorders, yet the connection between metabolic dysfunction and impaired neurogenesis remains unclear. In this study, we demonstrate that the …

Nature communications

47 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

Centromeric footprints preserve telomere integrity in ALT cancers.

Alternative lengthening of telomeres (ALT) is a specialized telomere extension mechanism associated with 5-10% of all cancers1. Although ALT has been linked to epigenetic dysregulation and genome instability, specific genomic and epigenetic rearrangements generated after …

Nature

47 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

Avoidance of rejuvenation: a stress test for evolutionary theories of aging.

The biological feasibility of human rejuvenation remains a subject of intense debate, yet answering this question is critical for guiding research strategies. Should aging research focus only on reversing aging in older individuals, or pausing …

npj aging

43 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

HK2 promotes angiogenesis through H3K18 lactylation in peripheral arterial disease.

Peripheral arterial disease (PAD) is characterized by impaired angiogenesis, yet the molecular mechanisms linking metabolic dysregulation to epigenetic reprogramming in endothelial cells (ECs) remain poorly understood. Here, we identify hexokinase 2 (HK2) as a critical …

Communications biology

38 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

roX1 and roX2 lncRNAs promote heterochromatinization in intestinal stem cells and impair longevity.

Maintenance of the genome and epigenome stability is vital for animal longevity. Long noncoding RNAs, roX1 and roX2, are known to be important in the male X chromosome dosage complex in Drosophila males. However, their …

EMBO reports

38 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

A beneficial environment promotes immune resilience through epigenetic regulation.

Environmental factors are often detrimental; however, certain environments enhance immune resilience. Notably, children raised on traditional farms show reduced allergies and asthma prevalence. Here, we investigated how a beneficial environment, using farm dust (FD) extract, …

Science advances

46 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other bioRxiv

Building the meiotic bouquet: A nuclear polarity pathway in Arabidopsis

Meiotic chromosome pairing requires the establishment of a polarized nuclear architecture, but how this polarity emerges from the interplay of telomeres, the nucleolus, and the nuclear envelope remains incompletely understood in plants. Using stage-resolved three-dimensional …

biorxiv (preprint)

34 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

Aging mechanisms and rejuvenation strategies for hematopoietic stem cells.

Hematopoietic stem cells (HSCs) transition through different functional states throughout life from emergence and expansion in the fetus, homeostasis maintenance in adulthood, and progressive functional decline with age. Aged HSCs are characterized by increased phenotypic …

Genome biology

38 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

TGM2-mediated serotonylation in tumor endothelial cells promotes angiogenesis and tumor growth in colorectal cancer.

Angiogenesis fuels colorectal cancer (CRC) growth and metastasis by supplying oxygen and nutrients to expanding tumors. Here, we define a TGM2-mediated serotonylation axis in tumor endothelial cells as a driver of angiogenesis and a key …

Cancer letters

38 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

Natural diversity of telomere length distributions across 100 Saccharomyces cerevisiae strains.

Telomeres gradually shorten at each cell division, and telomerase counteracts this shortening by elongating telomere sequences. This dynamic balance between elongation and shortening results in a steady-state telomere length (TL) distribution. Here, we develop a …

Genome research

38 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other bioRxiv

How bats' virus defenses may hold secrets to extreme longevity

Researchers sequenced genomes from 8 related bat species and found that bats evolved special adaptations to fight DNA viruses—and these same adaptations appear linked to cancer resistance and extended lifespans. This suggests that the ability …

biorxiv (preprint)

29 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

Maternal O-GlcNAc Transferase Is Required for the Asymmetry of Epigenetic Modifications in Mouse Zygotes.

After fertilization in mammals, there is an epigenetic asymmetry reflected by differences in DNA demethylation and histone modifications between female and male pronuclei (FPN and MPN, respectively). Based on its expression level and amount, we …

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

38 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

Reprogramming the immune suppressive tumor microenvironment in glioma enhances the efficacy of immune-mediated gene therapy.

Gliomas account for ∼80% of primary malignant brain tumors. Many CNS WHO grade 2-3 and some grade 4 gliomas harbor mutant isocitrate dehydrogenase 1 (mIDH1), which causes a gain-of-function mutation (IDH1 R132H) leading to the …

Molecular therapy. Oncology

38 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

Intracellular iron homeostasis-regulated epigenetic reprogramming contributes to -7/del(7q) leukemia.

Chromosome copy number variations are poorly understood drivers of human malignancies. -7/del(7q) is common in acute myeloid leukemia, confers a poor prognosis, and is thought to harbor several tumor suppressors. Previously, we identified the histone …

Nature communications

47 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

Sequence-directed R-loop formation coupled with DNA methylation reprogramming during polyploidization of Brachypodium.

R-loops are three-stranded structures consisting of a DNA:RNA hybrid and a single-stranded DNA, which play essential biological roles in eukaryotes. However, their functions during hybridization and the long-term evolutionary trajectory of polyploidization remain unclear. Here, …

The Plant journal : for cell and molecular biology

46 Early