Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging
Micro- and nanoplastics (MNPs) are emerging environmental contaminants with ubiquitous distribution and growing concern for reproductive health. Recent detection of MNPs in human follicular fluid and seminal plasma suggests that these particles can enter the …
Researchers found that caloric restriction slows aging of hematopoietic stem cells (blood-forming cells) in mice by activating specific genes like KDR and PU.1 that control whether these cells self-renew or differentiate. The discovery identifies molecular …
BACKGROUND: Caloric restriction (CR), achieved by reducing energy intake without malnutrition, has been shown to preserve muscle function and delay age-related declines in strength and mobility by modulating key metabolic and molecular pathways involved in …
Researchers studied rats bred for high and low running capacity and found that genes controlling muscle enhancers—regulatory DNA regions—drive differences in cardiorespiratory fitness by reshaping how cells handle energy and oxygen. This molecular map could …
Different definitions have been proposed for longevity, making it challenging to compare methods for estimating the economic significance of survival traits. Simple profit functions often fail to capture biological complexity, whereas bioeconomic models, though comprehensive, …
Researchers studied over 420 long-lived families across three generations and found that people who inherit fewer genetic risk factors for heart disease—particularly genes affecting cholesterol—tend to live longer and healthier lives. This suggests that staying …
Phthalate esters (PAEs), ubiquitous plastic additives, have emerged as persistent contaminants in aquatic ecosystems, yet their propagation from molecular initiating events to ecosystem-level collapse remains poorly integrated. This review synthesizes current knowledge on the source-to-sink …
Despite intensive glycemic control, diabetic cardiomyopathy (DCM) often progresses due to hyperglycemic memory (HGM), yet the specific cardiac cells perpetuating this injury remain unknown. To address this, we performed single-nucleus RNA sequencing (snRNA-seq) on hearts …
Aspartame (ASP) is a common artificial sweetener used in food and beverages. There is currently significant controversy surrounding the safety of aspartame. However, the molecular mechanisms of aspartame on innate immunity and lifespan remain poorly …
Fenvalerate, a representative type II pyrethroid insecticide, is well established in the literature. Fenvalerate exerts developmental and neurological toxicity. We assessed whether paternal fenvalerate exposure induces autism-like behavioral alterations in offspring using a mouse model. …
Endogenous bioelectric currents regulate development and regeneration, but their influence on organismal longevity and stem cell-mediated repair is not well understood. We demonstrate that a brief, clinically safe pulse of electrical current (PEC) produces lasting …
Researchers tested intermittent fasting in 10 genetically distinct mouse strains and found that how much fasting improves health and lifespan depends heavily on your genes and sex—not just the diet itself. This suggests that personalized …
After fertilization in mammals, there is an epigenetic asymmetry reflected by differences in DNA demethylation and histone modifications between female and male pronuclei (FPN and MPN, respectively). Based on its expression level and amount, we …
Peripheral arterial disease (PAD) is characterized by impaired angiogenesis, yet the molecular mechanisms linking metabolic dysregulation to epigenetic reprogramming in endothelial cells (ECs) remain poorly understood. Here, we identify hexokinase 2 (HK2) as a critical …
Aging-related diseases are aggravated by tissue hypoxia; however, the underlying mechanism remains unknown. Here, we report that the oxygen (O2) release capacity of red blood cells (RBCs) gradually decreases with age and is closely associated …
Maintenance of the genome and epigenome stability is vital for animal longevity. Long noncoding RNAs, roX1 and roX2, are known to be important in the male X chromosome dosage complex in Drosophila males. However, their …
Partial cellular reprogramming can modulate aging-associated decline across multiple tissues. However, whether targeting memory-encoding ensembles within specific brain regions is sufficient to restore cognitive function has remained unknown. In this issue of Neuron, Berdugo-Vega et …
The biological feasibility of human rejuvenation remains a subject of intense debate, yet answering this question is critical for guiding research strategies. Should aging research focus only on reversing aging in older individuals, or pausing …
Environmental factors are often detrimental; however, certain environments enhance immune resilience. Notably, children raised on traditional farms show reduced allergies and asthma prevalence. Here, we investigated how a beneficial environment, using farm dust (FD) extract, …
Researchers discovered that a brain receptor called NMUR-1 acts as a 'thermostat' for insulin signaling, adjusting how the body responds to different bacteria to improve survival. This mechanism reveals how the nervous system fine-tunes aging …