Prostate cancer is the most prevalent malignancy among men and is driven by multiple factors, including androgen signaling and its receptor. Long non-coding RNAs, such as PVT1, play key roles in cancer, particularly by regulating …
Allergic asthma is characterized by immune dysregulation, and deficiencies in regulatory T-cell (Treg) function are a hallmark of the disease. However, mechanisms of Treg impairment for their therapeutic correction remain poorly defined. The results showed …
Psoriasis is a chronic, immune-mediated dermatological disorder characterized by hyperproliferation of keratinocytes and dysregulated immune signaling. Although genome-wide association studies (GWAS) have identified susceptibility loci, the disease's multifactorial nature underscores the importance of non-genetic regulatory …
Researchers developed a gene therapy that protects telomeres (the caps on DNA) in heart cells, preventing damage signals that trigger mitochondrial dysfunction and heart failure. In mouse models and human cell cultures, this approach restored …
Scientists developed a technology that uses electromagnetic fields to remotely activate specific genes in living mice with precise timing and location control. They tested it by partially reversing aging processes, modeling Alzheimer's disease, and treating …
This review examines gene therapy's potential to combat aging by targeting fundamental aging processes across multiple organ systems, citing encouraging preclinical results in nervous, muscular, circulatory, and immune systems. However, the authors emphasize that translating …
Chemoresistance remains the primary cause of cancer treatment failure, yet current understanding remains fragmented across isolated mechanistic studies. This review provides a unified framework linking tumor microenvironment (TME) signaling, epigenetic reprogramming, and nanotherapeutic intervention as …
Growing consumer demand for clean-label and antibiotic-free meat products has intensified interest in plant-based bioactive compounds as next-generation antimicrobials. This review synthesizes current knowledge on the key phytochemicals essential oils, phenolics, terpenoids, alkaloids, and flavonoids …
BACKGROUND: Chronic psychological stress is a well-recognized factor in the exacerbation of allergic diseases, with IgE playing a central role in their pathophysiology. However, the exact molecular mechanisms by which stress hormones directly influence IgE …
BACKGROUND: Neuroblastoma (NB) is the most common extracranial solid tumor in children and is characterized by marked clinical heterogeneity and poor prognosis. MYCN amplification drives NB tumorigenesis through epigenetic reprogramming and is frequently accompanied by …
Reprogramming-induced rejuvenation (RIR) reverses cellular aging by transiently engaging early reprogramming states without full dedifferentiation. This review examines current developments in the molecular mechanisms, technological advances, and tissue-specific applications of RIR. Recent mechanistic insights highlight …