Cellular senescence and OSKM (Oct4, Sox2, Klf4, and Myc)-mediated reprogramming represent interconnected biological programs that both play important roles in regulating cellular plasticity. Recent studies have highlighted the role of p16-driven senescence in establishing a …
Researchers found that a protein called IL33 prevents placental aging; when it's missing, the placenta deteriorates through a chain reaction involving lactate buildup and broken autophagy (cellular cleanup). Senescence-targeting drugs like metformin and dasatinib+quercetin restored …
Researchers discovered that aging pancreas alpha cells trigger inflammatory immune responses linked to type 2 diabetes. In mice, calorie restriction reversed this inflammation by reducing immune cell recruitment to the pancreas. This suggests a new …
This review examines 'partial reprogramming'—a technique that temporarily activates rejuvenation factors to reverse aging hallmarks in cells and tissues without turning them into cancer-prone stem cells. Early evidence suggests it can restore tissue function and …
Glioblastoma is a highly aggressive primary brain tumour marked by extensive genomic and epigenomic alterations, cellular heterogeneity, and therapeutic resistance. Despite maximal surgical resection followed by chemoradiotherapy, median survival remains approximately 15 months, reflecting the …
Classic psychedelics such as lysergic acid diethylamide (LSD), psilocybin, N,N-dimethyltryptamine (DMT), and mescaline induce lasting changes in neuroplasticity and behavior that extend far beyond their acute pharmacological effects. Emerging evidence highlights that these enduring therapeutic …
Chronic contaminant exposure may impose hidden physiological costs long before obvious demographic or health effects become detectable in wildlife populations. Epigenetic clocks quantify biological ageing and may provide sensitive biomarkers of cumulative toxicological stress. Per- …
Sarcopenia, the progressive loss of skeletal muscle mass and function with age, is a major contributor to frailty and decreased quality of life in older adults. While physical exercise remains the most effective intervention, its …
Researchers found that mocetinostat, a drug that inhibits certain histone deacetylases, selectively kills senescent (aged) chondrocytes—cells that accumulate in arthritic joints—while leaving healthy cells intact. This discovery could lead to a new class of "senolytic" …
Histone deacetylases (HDACs) regulate transcription and catalyze deacetylation predominantly within canonical transcriptional complexes. Nevertheless, the mechanistic role of other HDAC-associated proteins in orchestrating this process remains incompletely understood. To systematically decode endogenous HDAC interactomes in …
Epigenetic reprogramming plays a critical role in connecting genotype to phenotype, providing the flexibility that allows organisms to adapt to developmental needs, environmental shifts, and disease challenges through the flexible regulation of gene expression. Histone …
Type 1 diabetes (T1D) is an autoimmune disorder characterized by insulin deficiency and hyperglycemia, driven by environmental insults and epigenetic reprogramming beyond genetic predisposition. Recent evidence suggests that systemic epigenetic dysregulation in T1D influences the …
This review examines how lysosomes—cellular recycling centers—actively regulate aging through two newly discovered signaling pathways (lysosomal surveillance response and transgenerational lysosomal signaling) and the protein TFEB. These findings suggest targeting lysosomal activity could be a …
Monocytes and macrophages are critically involved in the pathogenesis of atherosclerotic cardiovascular disease (ASCVD). Accumulating evidence indicates that monocytes and macrophages can develop innate immune memory and exhibit sustained pro-inflammatory properties in response to stimuli …
BACKGROUND AND AIMS: Adults with congenital heart disease tend to develop both cardiac and noncardiac age-related comorbidities earlier in life than the general population, suggesting accelerated biological ageing. Epigenetic clocks estimate biological age based on …
Biological ageing begins before birth, with early-life exposures shaping late-life health. These exposures drive health inequities early, yet specific exposures and the composition of the ageing exposome remain largely undefined. This gap may persist as …
BackgroundEpigenetic clocks are markers of biological aging that may vary in their sensitivity to environmental stressors and lifestyle modifiers. To evaluate the utility of these biomarkers as sensors of the human exposome, we investigated how …
Epigenetic clocks estimate biological age from DNA methylation patterns at CpG sites, providing robust predictions of mortality and morbidity risk. "Blue zones"--regions of exceptional longevity--offer a unique opportunity to investigate how biological aging diverges from …
Researchers identified six genetic variants linked to living past 85, 90, and 95 years in a Taiwanese population. When combined with health information, these genetic clues modestly improved predictions of extreme longevity, especially for those …
R-loops are three-stranded structures consisting of a DNA:RNA hybrid and a single-stranded DNA, which play essential biological roles in eukaryotes. However, their functions during hybridization and the long-term evolutionary trajectory of polyploidization remain unclear. Here, …