Genomics — OutliveHub

Promising Biomarkers — Aging clocks and measurement tools Cohort Study PubMed

What Slows (and Speeds) Skin Aging at the DNA Level

Identifies everyday habits and drugs linked to skin aging, offering new targets to test—but doesn't yet prove any slow aging.

Researchers analyzed DNA methylation patterns in 851 people and found 37 lifestyle, health, and drug factors linked to skin aging—some slowing it down, others speeding it up. Compounds like aspirin and dihydromyricetin showed associations with …

Clinical epigenetics

57 Promising

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

A Dual Approach to Glioblastoma Treatment with Epigenetic Reprogramming and Neurogenetic Modulation.

Glioblastoma is a highly aggressive primary brain tumour marked by extensive genomic and epigenomic alterations, cellular heterogeneity, and therapeutic resistance. Despite maximal surgical resection followed by chemoradiotherapy, median survival remains approximately 15 months, reflecting the …

Carcinogenesis

38 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Mendelian Randomization Revealed Potential of mTOR Inhibitors for Treatment of Osteoporosis: Evidence From GWAS and Transcriptome Data.

AIMS: Numerous preclinical studies suggested that targeted inhibition of mammalian target of rapamycin (mTOR) may be beneficial for the treatment of osteoporosis. However, the relevance of these findings to human populations remains unclear. We hypothesized …

International journal of endocrinology

38 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

CRISPR/Cas9 system-mediated p21 knockout impairs the MITF signaling pathway.

The CRISPR/Cas9 method facilitates targeted disruption of gene sequences, providing a reliable means to analyze gene-dependent regulatory pathways. This study aims to investigate melanogenesis in p21-knockout B16F1 cells generated by the CRISPR/Cas9 system. The mutation …

Journal of biotechnology

38 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Dose-Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload.

Iron overload induces cellular stress and is implicated in diverse pathological conditions. Nevertheless, the epigenetic mechanisms governing mammalian cellular responses to iron overload remain poorly characterized. Using multi-omics profiling in human granulosa cells, we show …

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

46 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Observational PubMed

Do taste receptor genes influence weight and lifespan?

Genes that control taste may influence body weight and how long you live, but this finding is early and only tested in one population.

Researchers found that genetic variations in taste receptors (particularly TAS1R3, TAS2R38, and CD36) were distributed differently in near-centenarians versus younger urban controls, and these variants associated with body weight in a population-specific way. The study …

Scientific reports

49 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other medRxiv

Multimodal Deep Learning Reveals the Modular Genetic Architecture of Cardiovascular Aging

Age is the dominant risk factor for cardiovascular disease, yet individuals of the same chronological age can differ markedly in the organs and biological pathways through which cardiovascular vulnerability emerges. We used deep learning to …

medrxiv (preprint)

39 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Sleep and aging: The role of DNA methylation.

Although its evolutionary origins remain poorly understood, sleep is a highly conserved physiological process crucial to animal life and widely recognized as a major determinant of human healthspan. Sleep disturbances are a major public health …

Experimental gerontology

44 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Gut microbiota and their role in male reproductive health.

The gut microbiota, as the "second genome" of the human body, plays a central regulatory role in maintaining host physiological homeostasis; conversely, its dysbiosis can impair male reproductive function via the "gut-testis axis", leading to …

NPJ science of food

46 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Observational PubMed

Genetic Markers of Healthy Aging: What Separates Long Life from Good Health in Old Age

Researchers studied 3,703 adults over 90 and 22,354 younger adults to identify genetic variants linked not just to living longer, but to living longer *well*. They found that certain genes (APOE, APOC1) are associated with …

Aging and disease

49 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other PubMed

Evolutionary genetics of ageing.

Modern humans now routinely survive to advanced ages, in far greater proportions than ancestral populations, and thus experience the consequences of molecular pathways optimized for youth yet still active in old age. Natural selection weakens …

Nature reviews. Genetics

46 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Potential factors contributing to extreme longevity in the Greenland shark.

The Greenland shark (Somniosus microcephalus) is a deep-sea vertebrate inhabiting the cold waters of the North Atlantic and Arctic Ocean and is renowned for its exceptional longevity, with individuals estimated to live for more than …

Journal of fish biology

38 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

Genetic associations with longevity in a Calabrian cohort: an exploratory genome-wide study.

Human longevity is a complex trait shaped by genetic background and population-specific factors. Calabria, a region in Southern Italy with a high prevalence of centenarians and relative genetic isolation, is a valuable model for investigating …

GeroScience

44 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other bioRxiv

Comparative genomics reveals signatures of distinct metabolic strategies and gene loss associated with Hydra immortality

Hydra is a freshwater cnidarian genus that provides a unique comparative model for aging research, contrasting the immortal H. vulgaris with the aging-inducible H. oligactis. Here, we report a high-quality, chromosome-level genome assembly of H. …

biorxiv (preprint)

34 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Regulatory function of ten‑eleven translocation‑2 in transcriptional mechanisms of demethylated myeloma cells.

Multiple myeloma (MM) is a malignant plasma cell disorder characterized by clonal expansion of plasma cells in bone marrow. Genetic aberrations in MM are well‑established, while epigenetic alterations, particularly DNA methylation, are increasingly recognized as …

Molecular medicine reports

38 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

Two novel indigenous Levilactobacillus brevis probiotic strains MKMB04 and MKMB05 enhance longevity and protect intestinal barrier function through antioxidant and anti-inflammatory mechanisms.

Aging is characterized by progressive oxidative stress, mitochondrial dysfunction, chronic inflammation and intestinal barrier impairment, contributing to increased susceptibility to age-associated disorders. Targeting redox imbalance and epithelial dysfunction represents a promising therapeutic strategy to promote …

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

38 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

Conditional deletion of human STN1 leads to telomere dysfunction, genome instability and proliferation defects.

CTC1-STN1-TEN1 (CST) is a heterotrimeric, RPA-like complex that binds single-stranded DNA, stimulates DNA polymerase α-primase, and functions in several genome maintenance pathways, including telomere maintenance and DNA replication and repair. During telomere replication, CST prevents …

Journal of cell science

46 Early

Promising Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Observational PubMed

Genetic secrets of extreme old age discovered in Taiwan

Genes linked to reaching 95 were found, but your heart health and blood pressure matter far more for long life.

Researchers identified six genetic variants linked to living past 85, 90, and 95 years in a Taiwanese population. When combined with health information, these genetic clues modestly improved predictions of extreme longevity, especially for those …

GeroScience

53 Promising

Disputed Biomarkers — Aging clocks and measurement tools Other bioRxiv

Making Epigenetic Age Clocks Work with DNA Sequencing Data

Researchers developed a standardized method to adapt epigenetic aging clocks—which measure biological age through DNA methylation patterns—from older microarray technology to newer sequencing platforms using cell-free DNA. This is important because sequencing is becoming the …

biorxiv (preprint)

24 Weak

Preliminary Biomarkers — Aging clocks and measurement tools Other PubMed

Epigenetic modulation of prostate cancer disparities in men with African ancestry.

Prostate cancer disproportionately affects men of African ancestry, yet the molecular mechanisms underlying these disparities remain poorly defined. Genomic studies have begun to reveal ancestry-linked risk alleles and somatic alterations, but the role of epigenetic …

Nature reviews. Urology

46 Early