Biomarkers of Aging — OutliveHub

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Review / Commentary PubMed

Why Astronauts Are the Perfect Model for Understanding Aging

Understanding how astronauts' bodies age fast in space could reveal new ways to keep older people healthy and strong longer.

Astronauts experience accelerated aging across multiple body systems—heart, muscles, brain, and immune function—due to space environment stressors like microgravity and radiation. This paper argues spaceflight is a uniquely informative human model for studying aging mechanisms …

Nature aging

35 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other medRxiv

Does frequency or diversity of leisure activity matter more for epigenetic ageing? Analyses of arts engagement and physical activity in the UK Household Longitudinal Study

Over the past decade, ageing clocks have become widely adopted as important tools for understanding biological ageing and have been redefining notions of "pro-longevity" lifestyles. However, this work is still at an early stage. Some …

medrxiv (preprint)

39 Early

Promising Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Observational PubMed

Genetic secrets of extreme old age discovered in Taiwan

Genes linked to reaching 95 were found, but your heart health and blood pressure matter far more for long life.

Researchers identified six genetic variants linked to living past 85, 90, and 95 years in a Taiwanese population. When combined with health information, these genetic clues modestly improved predictions of extreme longevity, especially for those …

GeroScience

53 Promising

Disputed Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other medRxiv

Eye fluid reveals mitochondrial damage in vision loss; alpha-ketoglutarate supplement shows promise

Researchers found abnormal mitochondrial function in patients with geographic atrophy (a blinding eye disease) by analyzing fluid from inside the eye. In a small early-stage trial, oral alpha-ketoglutarate supplementation successfully increased the compound's levels in …

medrxiv (preprint)

23 Weak

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Other bioRxiv

How Calorie Restriction Quiets Immune Attacks on Aging Pancreas Cells

A new clue about why pancreas cells fail during aging and diabetes—and evidence calorie restriction might reverse this in mice.

Researchers discovered that aging pancreas alpha cells trigger inflammatory immune responses linked to type 2 diabetes. In mice, calorie restriction reversed this inflammation by reducing immune cell recruitment to the pancreas. This suggests a new …

biorxiv (preprint)

26 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

A plant compound slowed aging in worms and mice by tweaking metabolism

A plant extract slowed aging and brain decline in mice—but we don't yet know if it works in humans.

Researchers isolated a fructan sugar compound (PKP-1b) from a traditional Chinese medicinal plant and found it extended lifespan and reduced aging signs in C. elegans and mice by dampening insulin/IGF-1 signaling—a well-known aging pathway. While …

Carbohydrate polymers

38 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

Can senolytic drugs restore fertility in female mice with fatty liver disease?

Researchers treated female mice with fatty liver disease (MASLD) using senolytic drugs—compounds that eliminate senescent (aged) cells—and found pregnancy rates improved, particularly through reduced aging and inflammation in the ovaries. However, the treatment had limited …

Biology of reproduction

39 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other bioRxiv

A single-cell atlas and aging clock define biological age and risk-associated stem cell states in human hematopoiesis

Aging of hematopoietic stem and progenitor cells (HSPCs) impairs regenerative capacity and predisposes to hematological diseases. Here, we constructed a comprehensive single-cell transcriptomic atlas comprising 186,123 CD34+ HSPCs spanning early prenatal development (6 post-conception weeks) …

biorxiv (preprint)

34 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … In Vitro PubMed

Five new plant alkaloids extend lifespan in worms by up to 9%

Plant compounds that might slow aging were found, but they've only been tested in worms, not people yet.

Researchers isolated five previously unknown alkaloid compounds from a plant called Benstonea parva and tested them in C. elegans worms. Four of the compounds extended lifespan by up to 9%, suggesting these plant molecules may …

Phytochemistry

39 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Other PubMed

How light therapy reverses sun damage by changing skin cell signaling

A light therapy commonly used to reduce wrinkles may work by blocking the cellular damage pathway that sun causes.

Intense pulsed light (IPL)—a common cosmetic treatment—reverses UV sun damage in skin cells by blocking a specific cellular damage pathway (ERK-AP-1-MMP). The study shows this works both in lab-grown human skin cells and in guinea …

Scientific reports

44 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Review / Commentary PubMed

How aging immune systems damage lungs—and what treatments might help

If your immune system ages slower, your lungs might stay healthier longer—but we need better treatments to prove it works.

This review examines how immunosenescence (age-related immune decline) drives lung diseases like COPD, fibrosis, and cancer, and surveys emerging treatments including senolytics, stem cell therapy, and lifestyle interventions. While it synthesizes current knowledge well, it's …

BMC medicine

36 Early

Preliminary Biomarkers — Aging clocks and measurement tools Observational PubMed

Can a Natural Serum Reverse Skin Aging? Testing Epigenetic Age Across Ethnicities

If confirmed, this suggests topical skincare could slow or reverse the cellular aging process, not just mask wrinkles.

Researchers found that skin aging leaves measurable epigenetic fingerprints that are consistent across different ethnic groups and skin types. A topical serum containing dihydromyricetin reduced these aging marks in a 60-person clinical trial, with visible …

Dermatology and therapy

39 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Observational medRxiv

The Sleep Sweet Spot: How 6–8 hours connects to biological aging across your whole body

Researchers analyzed sleep duration against 23 biological aging markers across multiple organ systems and found a U-shaped pattern: both too little (<6 hours) and too much (>8 hours) sleep are linked to faster biological aging, …

medrxiv (preprint)

39 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Cohort Study medRxiv

How Caloric Restriction Reshapes Your Metabolism Over 2 Years

A major clinical trial tracked 864 different metabolites in people doing long-term caloric restriction and found distinct shifts in carbohydrate and fat metabolism—with early changes during weight loss giving way to compensatory responses during weight …

medrxiv (preprint)

39 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other medRxiv

Exploring the exposome and unexplained variance in biological ageing - insights from a longitudinal twin study in adolescence and early adulthood

Biological ageing begins before birth, with early-life exposures shaping late-life health. These exposures drive health inequities early, yet specific exposures and the composition of the ageing exposome remain largely undefined. This gap may persist as …

medrxiv (preprint)

34 Early

Preliminary Biomarkers — Aging clocks and measurement tools Review / Commentary PubMed

How immune cells called NK cells shape healthy aging

This review synthesizes evidence that natural killer (NK) cells—a type of immune cell—undergo age-related changes that impair their ability to clear damaged cells and regulate inflammation, contributing to aging-related diseases. The authors propose NK cell …

Inflammation and regeneration

35 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Other medRxiv

Aging Out of the Blue: Estimating and Calibrating Region-specific Epigenetic Clocks for a Blue Zone via SuperLearner

Epigenetic clocks estimate biological age from DNA methylation patterns at CpG sites, providing robust predictions of mortality and morbidity risk. "Blue zones"--regions of exceptional longevity--offer a unique opportunity to investigate how biological aging diverges from …

medrxiv (preprint)

34 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary PubMed

Why longevity treatments work differently for men and women

Longevity treatments might work better or worse for men versus women—we need to test this to personalize medicine.

This review examines how anti-aging interventions affect males and females differently, exploring whether sex differences stem from baseline lifespan variations, body composition, metabolism, or hormone/chromosome differences. The authors argue that treating sex as a biological …

Ageing research reviews

38 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

Can a senolytic peptide slow brain aging and memory loss?

Scientists designed a drug that kills harmful aging cells in the brain and improved memory in animal tests; early human data are promising but limited.

This review examines FOXO4-DRI, a designed peptide that kills senescent (aged) cells by disrupting a protein interaction linked to brain aging. Animal studies show it improves memory and reverses some Alzheimer's-like damage, while early human …

Naunyn-Schmiedeberg's archives of pharmacology

35 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Review / Commentary PubMed

Can Young Blood Make You Younger? What Science Actually Shows (and Doesn't)

This review examines whether infusing young plasma can rejuvenate aging bodies, a concept supported by animal experiments but largely unproven in humans. The authors argue that while preclinical models show promise, current clinical applications of …

GeroScience

41 Early