Researchers tested 16 different biomarkers of aging (epigenetic clocks, blood proteins, telomeres, and others) in over 1,000 people tracked for 7 years. Two markers—Allostatic Load Index and DunedinPACE—stood out as the most reliable predictors of …
Long telomere length (TL) extends replicative capacity in vitro and predisposes to clonal hematopoiesis. We characterized the cancer phenotype in 51 individuals from 24 families with mutant POT1, a negative regulator of telomerase elongation (median …
Researchers developed a method to rejuvenate aging mesenchymal stem cells (MSCs) by temporarily expressing three genes via a non-integrating virus, then removing the virus. The rejuvenated cells showed extended lifespan, restored telomeres, and maintained their …
Researchers tested 14 different epigenetic clocks (DNA methylation–based age measures) in over 1,000 older adults and found that DunedinPACE, a newer clock, consistently predicted cognitive decline better than older clocks. This suggests DunedinPACE may be …
With aging, somatic mutations in hematopoietic stem and progenitor cells (HSPC) can give rise to clonal hematopoiesis of indeterminate potential (CHIP), a premalignant state associated with diverse age-related diseases. Here we report the largest multi-ancestry …
Researchers used lab-grown cells to show that mitochondrial DNA variants affecting energy production influence telomere length by controlling reactive oxygen species and NAD levels. This suggests that inherited mitochondrial traits may influence how quickly our …
Telomere biology disorders (TBDs) are characterized by bone marrow failure (BMF) and dysfunctional telomeres. So far, inherited mutations in 18 genes have been identified in TBDs. Here, we describe a child presenting with early BMF, …
Immunosenescence, an age-associated decline in immune function, is increasingly recognized as a central determinant of health and disease in older adults. Characterized by thymic involution, loss of naïve T cells, contraction of T cell receptor …
Telomere length is increasingly used as a proxy for an aging exposome", an index of non-genetic environmental (and behavioral) exposures that an individual encounters, leading to differences in rates of aging. One of the largest …
The conserved Ess1 prolyl isomerase (PIN1 in human) binds the carboxy-terminal domain (CTD) of RNA Pol II, and plays multiple roles in transcription regulation. Consistent with an essential role of the human PIN1 in telomere …
Telomeres gradually shorten at each cell division, and telomerase counteracts this shortening by elongating telomere sequences. This dynamic balance between elongation and shortening results in a steady-state telomere length (TL) distribution. Here, we develop a …
Telomeres are key biomarkers of cellular ageing, yet their dynamics remain poorly studied in tropical and short-lived bat species. Here, we present the first investigation of telomere length across age in Molossus molossus, a tropical …
Ageing biomarkers can predict mortality risk beyond chronological age. Recently, plasma proteins were used to estimate the biological ages of eleven human organs, including the brain, heart, liver, kidneys, and pancreas. Accelerated organ ageing is …
Background and Objectives: Biological age, reflecting the cumulative molecular and cellular damage such as telomere attrition, epigenetic alterations and mitochondrial dysfunction, may better capture age-related decline and Alzheimer's disease (AD) risk than chronological age. Most …
Ovarian aging is characterized by progressive follicular reserve depletion, mitochondrial dysfunction, oxidative stress, and endocrine decline. This review examines the molecular mechanisms driving ovarian aging and evaluates emerging therapeutic strategies to preserve reproductive longevity. Key …
In the absence of telomerase, telomere shortening triggers replicative senescence, a tumor suppressor mechanism that is also associated with oncogenic genomic instability. Yet, the precise mechanism that connects these seemingly opposing forces remains poorly understood. …
Allergic asthma is characterized by immune dysregulation, and deficiencies in regulatory T-cell (Treg) function are a hallmark of the disease. However, mechanisms of Treg impairment for their therapeutic correction remain poorly defined. The results showed …
Researchers enrolled 209 companion dogs in a 30-month study to identify biomarkers of aging that could make dogs a better translational model for human longevity research. Early findings show consistent age-related changes in blood work, …
This review examines how chemical modifications to RNA molecules regulate telomere maintenance—the process that prevents chromosome shortening and cellular aging. The authors propose that understanding these epitranscriptomic controls could reveal new targets for treating aging-related …
Hypothesized to be a diet-derived 'longevity vitamin', Ergothioneine (ET) is increasingly recognized for its potential to modulate cellular homeostasis and support healthy ageing in preclinical models. This systematic review, encompassing evidence from 2005 to 2025, …