Caloric Restriction — OutliveHub

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Animal Model bioRxiv

Eating Only During an 8-Hour Window Extended Male Mouse Lifespan by 12%

Eating during only 8 hours daily may help you stay healthier longer, but we need human studies to know if it extends human lifespan.

Researchers found that limiting daily eating to either 12 or 8 hours improved health markers in both male and female mice, with the stricter 8-hour window extending male lifespan by 12% but showing no significant …

biorxiv (preprint)

30 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model bioRxiv

Could LSD Help Us Live Longer? Early C. elegans Study Suggests Yes

Early evidence that LSD might slow aging in lab worms, but human trials are years away and results could be wrong.

Researchers found that LSD extended lifespan in C. elegans worms and reduced aging-related cellular damage, possibly by triggering metabolic pathways similar to caloric restriction. However, this is very early-stage research in worms with zero human …

biorxiv (preprint)

25 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Other bioRxiv

How Calorie Restriction Quiets Immune Attacks on Aging Pancreas Cells

A new clue about why pancreas cells fail during aging and diabetes—and evidence calorie restriction might reverse this in mice.

Researchers discovered that aging pancreas alpha cells trigger inflammatory immune responses linked to type 2 diabetes. In mice, calorie restriction reversed this inflammation by reducing immune cell recruitment to the pancreas. This suggests a new …

biorxiv (preprint)

26 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary PubMed

Why longevity treatments work differently for men and women

Longevity treatments might work better or worse for men versus women—we need to test this to personalize medicine.

This review examines how anti-aging interventions affect males and females differently, exploring whether sex differences stem from baseline lifespan variations, body composition, metabolism, or hormone/chromosome differences. The authors argue that treating sex as a biological …

Ageing research reviews

38 Early

Promising Lifestyle — Diet, exercise, and behavioral interventions Cohort Study PubMed

How calorie restriction reduces aging inflammation through immune pathway control

Eating less triggers your body to turn down an immune switch that normally drives aging and inflammation—a new target for anti-aging drugs.

A study of people eating 14% fewer calories for 2 years found their bodies reduced an immune protein (C3a) that drives inflammation during aging. Blocking this protein in mice reduced age-related inflammation, suggesting complement pathway …

Nature aging

60 Promising

Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model bioRxiv

How Fruit Flies Switch Between Fat and Carb Storage When Deprived of Dietary Fat

Scientists found how bodies switch between storing fat and carbs when fat is unavailable—useful for understanding metabolism and aging.

Researchers found that when fruit flies can't make their own fat, their bodies switch to storing energy as carbohydrates instead, allowing normal development but shortening lifespan and reducing reproduction. This reveals a metabolic control system …

biorxiv (preprint)

29 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Animal Model PubMed

Why fasting works differently for different people: A genetic explanation

Researchers tested intermittent fasting in 10 genetically distinct mouse strains and found that how much fasting improves health and lifespan depends heavily on your genes and sex—not just the diet itself. This suggests that personalized …

Genetics

47 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Animal Model PubMed

Why Low-Cholesterol Diets Shorten Lifespan in Female Fruit Flies: A Gut Health Story

Researchers found that female fruit flies on very low-cholesterol diets had shorter lifespans and developed leaky gut problems. Interestingly, not all flies showed gut damage before dying, suggesting cholesterol may be essential for maintaining intestinal …

npj aging

44 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Animal Model PubMed

How caloric restriction keeps blood-forming stem cells young in mice

Researchers found that caloric restriction slows aging of hematopoietic stem cells (blood-forming cells) in mice by activating specific genes like KDR and PU.1 that control whether these cells self-renew or differentiate. The discovery identifies molecular …

Nature communications

48 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Cohort Study medRxiv

How Caloric Restriction Reshapes Your Metabolism Over 2 Years

A major clinical trial tracked 864 different metabolites in people doing long-term caloric restriction and found distinct shifts in carbohydrate and fat metabolism—with early changes during weight loss giving way to compensatory responses during weight …

medrxiv (preprint)

39 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

No evidence for squaring the survival curve: lifespan-extending treatments increase variation in age- at-death.

Geroscience has the goal of extending lifespan through geroprotective interventions. These interventions are typically imparted on groups of individuals, with their efficacy judged by increases in the average age-at-death. A more equitable outcome, which looks …

Biology letters

38 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Caloric Restriction and Time-Restricted Eating in Older Adults with Overweight or Obesity: The Health, Aging, and Later-Life Outcomes Pilot Study.

BACKGROUND: In animal models, caloric restriction (CR) and time-restricted eating (TRE) extend lifespan and healthspan; however, the long-term benefits in humans are unknown. The goal of the Health, Aging and Later-Life Outcomes Pilot (HALLO-P) was …

The journals of gerontology. Series A, Biological sciences and medical sciences

46 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Other PubMed

Dynamics of gut bacteriophage in diversity outbred mice studied over lifespan and during extreme caloric restriction.

BACKGROUND: The majority of bacteria in the vertebrate gut harbor integrated bacterial viruses ("bacteriophages" or "phages"; integrated phage are termed "prophages"). To probe phage replication strategies in the mammalian gut microbiome, we investigated phage activity …

Microbiome

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Dietary restriction in aging and longevity.

Different types of dietary restriction (DR) have been practiced by humans for religious and medical purposes for millennia, but only during the past three decades has the scientific study of DR at cellular and molecular …

Nature aging

47 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Links Between Autophagy and Healthy Aging.

Several if not all manifestations of aging can be postponed by a healthy lifestyle involving a balanced diet coupled with regular exercise and sufficient sleep. Similarly, various genetic and pharmacological longevity interventions can exert beneficial …

Journal of molecular biology

38 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Weight Regain Reverses Caloric Restriction-Induced Benefits on the Insulin-IGF-1 Nutrient-Sensing Pathway: Post Hoc Analysis From the CALERIE-2 Randomized Controlled Trial.

OBJECTIVE: To investigate the long-term metabolic and hormonal consequences of sustained weight loss versus weight regain after 1 year of caloric restriction (CR), with attention to insulin resistance and type 2 diabetes risk. RESEARCH DESIGN …

Diabetes care

38 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Animal Model PubMed

How caloric restriction preserves liver and kidney health in aging mice

Researchers found that cutting calorie intake by 50% in mice slowed age-related damage to the liver and kidneys, reducing fibrosis, metabolic stress, and cellular senescence markers. The protective effect appeared linked to activation of SIRT1, …

Histology and histopathology

37 Early

Preliminary Genetics & Genomics — Gene therapy, CRISPR, epigenetic clocks, and genomic determinants of aging Animal Model PubMed

How fat tissue controls aging through a molecular switch for insulin

Researchers found that a protein called Dicer-1 in fat tissue acts as a master regulator of aging in fruit flies by controlling insulin levels throughout the body. When Dicer-1 is reduced, it triggers a chain …

Proceedings of the National Academy of Sciences of the United States of America

47 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Animal Model bioRxiv

Cutting dietary valine extends male mouse lifespan by 23%

One amino acid in protein might extend male lifespan; needs human testing to know if it matters for you.

Researchers found that lifelong restriction of valine, a branched-chain amino acid in protein, improved metabolic health and reduced aging markers in both male and female mice, but only extended lifespan in males by 23%. The …

biorxiv (preprint)

31 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

How Caffeine Might Extend Life by Boosting Fat Breakdown

Caffeine might extend lifespan in worms by helping cells burn stored fat, but we don't know if this works in humans yet.

Researchers found that caffeine extends lifespan in C. elegans worms by activating lysosomal lipases—proteins that break down stored fat—mimicking the longevity benefits of caloric restriction. While mechanistically interesting, this is an early-stage animal study that …

Molecules and cells

42 Early