Lifestyle — OutliveHub

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary PubMed

Why longevity treatments work differently for men and women

Longevity treatments might work better or worse for men versus women—we need to test this to personalize medicine.

This review examines how anti-aging interventions affect males and females differently, exploring whether sex differences stem from baseline lifespan variations, body composition, metabolism, or hormone/chromosome differences. The authors argue that treating sex as a biological …

Ageing research reviews

38 Early

Promising Lifestyle — Diet, exercise, and behavioral interventions Cohort Study PubMed

Healthy Habits Matter More Than Genes for Living Past 80

Your daily choices—diet, exercise, sleep—cut death risk by 40% even at age 80+, more than your genes do.

In a study of 1,545 Chinese people aged 80+, researchers found that maintaining healthy lifestyle factors reduced death risk by 41% and added nearly 7 years of life—even more than genetic advantages. Importantly, good genes …

npj aging

51 Promising

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Animal Model bioRxiv

Eating Only During an 8-Hour Window Extended Male Mouse Lifespan by 12%

Eating during only 8 hours daily may help you stay healthier longer, but we need human studies to know if it extends human lifespan.

Researchers found that limiting daily eating to either 12 or 8 hours improved health markers in both male and female mice, with the stricter 8-hour window extending male lifespan by 12% but showing no significant …

biorxiv (preprint)

30 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Other PubMed

Nutrition's role in extending healthspan: CRN-international symposium report.

The annual CRN-International symposium, “Food Is Medicine: The Role of Nutrition in Extending Healthspan” sought to address the profound impact of dietary habits on health and healthy lifespan, as judicious nutritional choices can serve as …

European journal of nutrition

38 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Cohort Study medRxiv

How Caloric Restriction Reshapes Your Metabolism Over 2 Years

A major clinical trial tracked 864 different metabolites in people doing long-term caloric restriction and found distinct shifts in carbohydrate and fat metabolism—with early changes during weight loss giving way to compensatory responses during weight …

medrxiv (preprint)

39 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary PubMed

Combining Skin Treatments Inside and Out to Slow Aging

This explains why treating skin from inside and outside together might work better than either alone, but doesn't prove it actually does.

This review argues that combining topical skin treatments (retinoids, peptides, antioxidants) with internal supplements (NAD+ precursors, collagen peptides, polyphenols) can target multiple aging mechanisms simultaneously. While conceptually sound, the paper is a narrative review without …

Dermatology and therapy

32 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Other PubMed

Natural Antimicrobial Activity of Nettle (Urtica dioica L.) Leaf Extract for Shelf-Life Extension of Mashed Potatoes.

The growing demand for minimally processed clean-label foods has intensified interest in natural antimicrobials as alternatives to synthetic preservatives. However, very little is known about the antimicrobial potential of several wild edible plants when incorporated …

Food science & nutrition

46 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Animal Model PubMed

Why Low-Cholesterol Diets Shorten Lifespan in Female Fruit Flies: A Gut Health Story

Researchers found that female fruit flies on very low-cholesterol diets had shorter lifespans and developed leaky gut problems. Interestingly, not all flies showed gut damage before dying, suggesting cholesterol may be essential for maintaining intestinal …

npj aging

44 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Animal Model PubMed

How caloric restriction preserves liver and kidney health in aging mice

Researchers found that cutting calorie intake by 50% in mice slowed age-related damage to the liver and kidneys, reducing fibrosis, metabolic stress, and cellular senescence markers. The protective effect appeared linked to activation of SIRT1, …

Histology and histopathology

37 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary PubMed

Why Blue Zone Residents Live So Long: A Heart Health Perspective

Understanding why some populations live longer and healthier might help the rest of us design better prevention strategies.

This review paper synthesizes what we know about why people in five Blue Zone regions (Okinawa, Sardinia, Nicoya Peninsula, Ikaria, Loma Linda) live exceptionally long lives with low heart disease rates. The authors propose that …

Cardiology in review

34 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary PubMed

Should You Try Fasting for Longevity? What Scientists Currently Know

This paper honestly explains what we do and don't know about whether fasting helps people live longer, and what studies would actually prove it.

This perspective paper reviews evidence that intermittent fasting may improve metabolic health and potentially extend lifespan, but concludes the human evidence remains too limited to recommend widespread adoption. The authors outline what rigorous studies are …

Biogerontology

37 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Other PubMed

Assessing the causal impact of leisure-time physical activity and screen time on lifespan: a Mendelian randomization study.

OBJECTIVES: Observational studies have consistently shown physical activity associated with lower mortality. Randomized controlled trials to confirm the value of physical activity for lifespan in the general population are challenging to conduct. To address this …

European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity

43 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Other PubMed

Remembrance of things past: Towards a life-course biology of aging.

Globally, the growing proportion of older individuals is imposing personal and societal costs. However, interventions that slow aging are possible; for example, dampened nutrient signaling pathway activity in animal models promotes better health later in …

PLoS biology

38 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Animal Model PubMed

How Fasting Triggers a Hidden Hormone to Keep Us Healthy as We Age

This reveals how fasting keeps us functioning better as we age, not by living longer but by keeping us healthier.

Researchers discovered that fasting and calorie restriction activate a hormone called ADIOL, which works through a specific molecular pathway to improve healthspan—the years we spend healthy and functional—in worms. While ADIOL doesn't extend lifespan itself, …

Aging cell

43 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Other PubMed

JOINT EFFECT OF LIGHT AND MODERATE-TO-VIGOROUS PHYSICAL ACTIVITY ON LONGEVITY.

The objective of this study was to assess the combined effect of light and moderate-to-vigorous physical activity on all-cause mortality risk. This was a prospective cohort study of 3949 adults aged 40 and older. Exposures …

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

38 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Animal Model PubMed

Can the smell of toasted bread slow aging? C. elegans study suggests yes

Smelling food aromas might activate anti-aging pathways in cells, but we don't know if this works in humans yet.

Researchers exposed C. elegans worms to odors from the Maillard reaction (the browning that happens when food is cooked) and found it extended lifespan, improved movement, and boosted stress resistance—effects that depended on activating a …

Bioscience, biotechnology, and biochemistry

40 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Animal Model bioRxiv

Cutting dietary valine extends male mouse lifespan by 23%

One amino acid in protein might extend male lifespan; needs human testing to know if it matters for you.

Researchers found that lifelong restriction of valine, a branched-chain amino acid in protein, improved metabolic health and reduced aging markers in both male and female mice, but only extended lifespan in males by 23%. The …

biorxiv (preprint)

31 Early

Promising Lifestyle — Diet, exercise, and behavioral interventions Cohort Study PubMed

How calorie restriction reduces aging inflammation through immune pathway control

Eating less triggers your body to turn down an immune switch that normally drives aging and inflammation—a new target for anti-aging drugs.

A study of people eating 14% fewer calories for 2 years found their bodies reduced an immune protein (C3a) that drives inflammation during aging. Blocking this protein in mice reduced age-related inflammation, suggesting complement pathway …

Nature aging

60 Promising

Promising Lifestyle — Diet, exercise, and behavioral interventions Cohort Study PubMed

Healthy Lifestyle Habits Add Years of Good Health in Older Adults

Following four healthy habits—eating well, exercising, not smoking, and moderate drinking—helps you live longer in good health, even if you're already aging well.

A study of over 11,000 healthy older Australians found that following four lifestyle behaviors—Mediterranean diet, regular exercise, not smoking, and moderate drinking—was associated with living about 10% longer without disability or dementia. The benefits were …

Journal of the American Geriatrics Society

62 Promising

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Animal Model PubMed

How Intermittent Fasting Protects Brain DNA Through Metabolic Signaling

In mice, intermittent fasting triggers the production of a metabolite called β-hydroxybutyrate that signals cells to activate DNA repair and antioxidant defense programs in the hippocampus. These protective effects persisted even after mice resumed normal …

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

41 Early