Diet, exercise, and behavioral interventions
The demands of competing in the Olympic games is remarkably similar to that of surgeon in theatre. Both require sustained precision, high cognitive load, emotional regulation, physical endurance, and the weight of outcomes that matter …
Researchers found that female fruit flies on very low-cholesterol diets had shorter lifespans and developed leaky gut problems. Interestingly, not all flies showed gut damage before dying, suggesting cholesterol may be essential for maintaining intestinal …
Researchers found that cutting calorie intake by 50% in mice slowed age-related damage to the liver and kidneys, reducing fibrosis, metabolic stress, and cellular senescence markers. The protective effect appeared linked to activation of SIRT1, …
Researchers exposed C. elegans worms to odors from the Maillard reaction (the browning that happens when food is cooked) and found it extended lifespan, improved movement, and boosted stress resistance—effects that depended on activating a …
The annual CRN-International symposium, “Food Is Medicine: The Role of Nutrition in Extending Healthspan” sought to address the profound impact of dietary habits on health and healthy lifespan, as judicious nutritional choices can serve as …
In mice, intermittent fasting triggers the production of a metabolite called β-hydroxybutyrate that signals cells to activate DNA repair and antioxidant defense programs in the hippocampus. These protective effects persisted even after mice resumed normal …
In Indonesia, adults living in rural areas have a longer life expectancy than their urban counterparts. Beyond observed longevity, attention has focused on lifespan and healthspan expectations as predictors of health outcomes. This study examines …
A major clinical trial tracked 864 different metabolites in people doing long-term caloric restriction and found distinct shifts in carbohydrate and fat metabolism—with early changes during weight loss giving way to compensatory responses during weight …
Researchers discovered that fasting and calorie restriction activate a hormone called ADIOL, which works through a specific molecular pathway to improve healthspan—the years we spend healthy and functional—in worms. While ADIOL doesn't extend lifespan itself, …
Time-restricted feeding (TRF) aligned with an organism's circadian rhythm has been shown to improve health, but its long-term effects on healthspan and lifespan in mammals, especially under standard dietary conditions that do not promote obesity, …
This review examines SIRT1, a protein activated by exercise that helps counteract multiple aging processes across the body. Evidence from animal and human studies shows different exercise types can boost SIRT1 levels in key organs, …
This study evaluated the effects of ozone (O₃) on the population dynamics of aerobic mesophilic microorganisms and the preservation of the physicochemical quality of mushrooms (Lentinula edodes) during storage. Samples of 100 g were treated …
This collection brings together 16 studies from researchers worldwide showing that circadian rhythms—your body's 24-hour internal clock—play a central role in aging and longevity. By understanding how these rhythms break down with age, scientists are …
Researchers analyzed sleep duration against 23 biological aging markers across multiple organ systems and found a U-shaped pattern: both too little (<6 hours) and too much (>8 hours) sleep are linked to faster biological aging, …
Glucose oxidase (GOX) is widely recognized for its potential in food preservation, yet its practical application is often limited by insufficient stability and catalytic efficiency under processing conditions. In this study, a GOX from Aspergillus …
Food loss and waste remain a major global challenge, with nearly one-third of all food produced annually being discarded or wasted, while conventional plastic-based packaging continues to exacerbate environmental pollution and microplastic accumulation. Here, we …
Aging is a time-dependent process characterized by a gradual decline in physiological functions, ultimately leading to increased risk of degenerative diseases, health issues, and death. With the growing number of older people and rising health …
Dental prosthesis failure is often associated with biofilm-mediated infections, yet the combined roles of surface roughness and material chemistry remain underexplored. This observational, retrospective study investigated associations between these factors and biofilm density, pathogen selection, …
In a study of 1,545 Chinese people aged 80+, researchers found that maintaining healthy lifestyle factors reduced death risk by 41% and added nearly 7 years of life—even more than genetic advantages. Importantly, good genes …
OBJECTIVES: Observational studies have consistently shown physical activity associated with lower mortality. Randomized controlled trials to confirm the value of physical activity for lifespan in the general population are challenging to conduct. To address this …