The objective of this study was to assess the combined effect of light and moderate-to-vigorous physical activity on all-cause mortality risk. This was a prospective cohort study of 3949 adults aged 40 and older. Exposures …
OBJECTIVES: Observational studies have consistently shown physical activity associated with lower mortality. Randomized controlled trials to confirm the value of physical activity for lifespan in the general population are challenging to conduct. To address this …
Over the past decade, ageing clocks have become widely adopted as important tools for understanding biological ageing and have been redefining notions of "pro-longevity" lifestyles. However, this work is still at an early stage. Some …
Several if not all manifestations of aging can be postponed by a healthy lifestyle involving a balanced diet coupled with regular exercise and sufficient sleep. Similarly, various genetic and pharmacological longevity interventions can exert beneficial …
Researchers created an AI-powered blood biomarker (SASP Score) that measures senescent cell burden and successfully predicted mortality, dementia, heart attacks, and stroke in large population studies. The score also changed in response to exercise intervention, …
Researchers fed pregnant fruit flies a high-fat diet supplemented with tauroursodeoxycholic acid (TUDCA), a bile acid derivative, and found their offspring lived ~19% longer with better stress resistance and mitochondrial health. The lifespan benefit depended …
This review examines how anti-aging interventions affect males and females differently, exploring whether sex differences stem from baseline lifespan variations, body composition, metabolism, or hormone/chromosome differences. The authors argue that treating sex as a biological …
Researchers used artificial intelligence to analyze 70,000 MRI scans and found that medical imaging can detect which organs are aging faster than normal—and these patterns correlate with diseases like MS and COPD, plus lifestyle factors …
Researchers gave middle-aged mice metformin (a common diabetes drug) and found it slowed aging-related weakness, preserved muscle mass and strength, and maintained bone and joint health. The findings suggest metformin might be a cheap, widely-available …
Researchers studied rats bred for high and low running capacity and found that genes controlling muscle enhancers—regulatory DNA regions—drive differences in cardiorespiratory fitness by reshaping how cells handle energy and oxygen. This molecular map could …
This review examines SIRT1, a protein activated by exercise that helps counteract multiple aging processes across the body. Evidence from animal and human studies shows different exercise types can boost SIRT1 levels in key organs, …
This review examines how polyamines (especially spermidine) regulate autophagy—the cell's cleanup system—in skeletal muscle, and how exercise amplifies this process to combat age-related muscle loss. The authors propose that spermine oxidase, an enzyme that produces …
A study of over 11,000 healthy older Australians found that following four lifestyle behaviors—Mediterranean diet, regular exercise, not smoking, and moderate drinking—was associated with living about 10% longer without disability or dementia. The benefits were …
Reducing activity of the mechanistic/mammalian target of rapamycin (mTOR) with rapamycin extends lifespan and healthspan in many species. The mechanisms by which mTOR regulates lifespan and healthspan, however, are still unknown. Understanding how mTOR signaling …
Epidemiological, preclinical, and clinical studies increasingly support exercise as a potent neuroprotective and disease-modifying intervention in Parkinson's disease (PD). Preclinical studies, including toxin- and α-synuclein-based models, using voluntary, forced, and skilled exercise paradigms demonstrate preservation …
BACKGROUND: Maximising healthspan, the period of life spent in good health, is a public health priority. This review aimed to summarise the current evidence from randomised controlled trials on interventions that can prolong healthspan in …
While Life's Essential 8 (LE8) provides a comprehensive measure of cardiovascular health (CVH), its association with mortality among the oldest-old, including centenarians, remains unclear. This study evaluated the relationship between LE8-defined CVH and all-cause mortality …
Endogenous bioelectric currents regulate development and regeneration, but their influence on organismal longevity and stem cell-mediated repair is not well understood. We demonstrate that a brief, clinically safe pulse of electrical current (PEC) produces lasting …
BACKGROUND: Successful aging (SA) is a key focus in gerontological research, highlighting the importance of maintaining physical, cognitive, and social well-being. Nutrition is a critical determinant of health in older adults, and sustainable healthy eating …
Researchers identified a liver-derived protein called GPLD1 that transfers exercise's cognitive benefits to the brain by targeting blood vessel dysfunction. In aging and Alzheimer's mouse models, boosting GPLD1 or blocking its downstream target TNAP restored …