Time-restricted eating and periodic fasting protocols
Intermittent fasting (IF) has gained increasing attention as a lifestyle intervention potentially influencing metabolic health and aging, partly through modulation of oxidative stress. This narrative review synthesizes current evidence on the effects of IF on …
Exposure to low levels of environmental challenges, known as hormetic stress, fosters subsequent stress resistance and promotes healthy aging in later life. However, specific mechanisms governing transcriptional reprogramming upon hormetic nutrient stress remain elusive. Here, …
BackgroundEpigenetic clocks are DNA methylation-based biomarkers increasingly used in aging research and clinical trials. A recent assessment of 18 clocks across multiple short-term perturbations concluded that most demonstrate only moderate biological reliability, raising concerns about …
Southern European countries have some of the highest life expectancies in the world, yet they display relatively high frailty. We examined different diets to identify compositions that promote both healthspan and strength in mice. The …
Researchers tested intermittent fasting in 10 genetically distinct mouse strains and found that how much fasting improves health and lifespan depends heavily on your genes and sex—not just the diet itself. This suggests that personalized …
Researchers conducted an intensive year-long self-study (N=1) combining time-restricted eating, exercise, Mediterranean diet, and continuous biomarker monitoring to assess how well a healthy person's body adapts to stress. The study demonstrates new methods for tracking …
BACKGROUND: In animal models, caloric restriction (CR) and time-restricted eating (TRE) extend lifespan and healthspan; however, the long-term benefits in humans are unknown. The goal of the Health, Aging and Later-Life Outcomes Pilot (HALLO-P) was …
Different types of dietary restriction (DR) have been practiced by humans for religious and medical purposes for millennia, but only during the past three decades has the scientific study of DR at cellular and molecular …
Addressing endocrine resistance in hormone receptor-positive breast cancer, Padrão et al. identify the glucocorticoid receptor (GR) as the key transducer of fasting benefits. They demonstrate that pharmacological GR activation recapitulates antitumor efficacy, offering a targeted …
In mice, intermittent fasting triggers the production of a metabolite called β-hydroxybutyrate that signals cells to activate DNA repair and antioxidant defense programs in the hippocampus. These protective effects persisted even after mice resumed normal …
Researchers found that limiting daily eating to either 12 or 8 hours improved health markers in both male and female mice, with the stricter 8-hour window extending male lifespan by 12% but showing no significant …
This perspective paper reviews evidence that intermittent fasting may improve metabolic health and potentially extend lifespan, but concludes the human evidence remains too limited to recommend widespread adoption. The authors outline what rigorous studies are …
Researchers discovered that fasting and calorie restriction activate a hormone called ADIOL, which works through a specific molecular pathway to improve healthspan—the years we spend healthy and functional—in worms. While ADIOL doesn't extend lifespan itself, …
Diabetic cardiomyopathy (DCM) is a major contributor to heart failure in patients with diabetes. Although berberine (BBR) exhibits broad metabolic and cardiovascular benefits, its mechanistic role in DCM remains incompletely defined. Cardiovascular function was assessed …
Time-restricted feeding (TRF), which confines food intake to a defined daily window, has emerged as a promising nonpharmacological strategy to improve health by aligning behavior and physiology with the endogenous circadian clock. Preclinical research has …
Reducing activity of the mechanistic/mammalian target of rapamycin (mTOR) with rapamycin extends lifespan and healthspan in many species. The mechanisms by which mTOR regulates lifespan and healthspan, however, are still unknown. Understanding how mTOR signaling …
The number of patients taking glucagon-like peptide-1 receptor agonists (GLP-1RAs) is increasing. Beyond diabetes and weight management, these medications have various effects within the head and neck with both beneficial and potentially adverse clinical implications. …
BACKGROUND AND AIMS: Pulse-based diets are naturally low in methionine, an amino acid whose restriction has been linked to improved metabolic health and longevity. This study evaluated how a pulse-protein diet (PPD), relative to a …
Age-related cognitive decline is a major public health concern, with few effective interventions available. Intermittent fasting (IF) has emerged as a promising metabolic intervention, potentially enhancing neuroprotection through increased β-hydroxybutyrate (BHB) production. This study aimed …
Time-restricted feeding (TRF) aligned with an organism's circadian rhythm has been shown to improve health, but its long-term effects on healthspan and lifespan in mammals, especially under standard dietary conditions that do not promote obesity, …