Periodontitis is a chronic inflammatory disease characterized by progressive destruction of periodontal tissues and alveolar bone, traditionally attributed to microbial dysbiosis. Emerging evidence suggests that host-intrinsic factors, including circadian rhythm disruption (CRD) and cellular senescence, …
Circadian disruption is increasingly linked to adverse health outcomes, yet its mechanistic role in age-related functional decline under environmental exposure remains unclear. This study investigated whether di(2-ethylhexyl) phthalate (DEHP), a ubiquitous environmental plasticizer and well-established …
Researchers found that limiting daily eating to either 12 or 8 hours improved health markers in both male and female mice, with the stricter 8-hour window extending male lifespan by 12% but showing no significant …
The temporal coupling between cortical blood-oxygen-level-dependent (BOLD) activity and CSF inflow has recently been proposed as a non-invasive marker of glymphatic function, a brain-wide clearance system closely linked to sleep, neuromodulatory regulation and neurodegeneration. Reduced …
Longevity medicine is transforming healthcare by shifting the focus from disease treatment toward the preservation of function, resilience, and healthspan. In parallel, artificial intelligence (AI) has emerged as a powerful catalyst accelerating this transition through …
Time-restricted feeding (TRF) aligned with an organism's circadian rhythm has been shown to improve health, but its long-term effects on healthspan and lifespan in mammals, especially under standard dietary conditions that do not promote obesity, …
Several if not all manifestations of aging can be postponed by a healthy lifestyle involving a balanced diet coupled with regular exercise and sufficient sleep. Similarly, various genetic and pharmacological longevity interventions can exert beneficial …
Ovarian aging is characterized by progressive follicular reserve depletion, mitochondrial dysfunction, oxidative stress, and endocrine decline. This review examines the molecular mechanisms driving ovarian aging and evaluates emerging therapeutic strategies to preserve reproductive longevity. Key …
Time-restricted feeding (TRF), which confines food intake to a defined daily window, has emerged as a promising nonpharmacological strategy to improve health by aligning behavior and physiology with the endogenous circadian clock. Preclinical research has …
The number of patients taking glucagon-like peptide-1 receptor agonists (GLP-1RAs) is increasing. Beyond diabetes and weight management, these medications have various effects within the head and neck with both beneficial and potentially adverse clinical implications. …
Astronauts experience accelerated aging across multiple body systems—heart, muscles, brain, and immune function—due to space environment stressors like microgravity and radiation. This paper argues spaceflight is a uniquely informative human model for studying aging mechanisms …
Polycystic ovary syndrome (PCOS) is a highly heterogeneous endocrine-metabolic disorder whose core pathological features-follicular atresia and ovulatory dysfunction-are attributed to functional failure of ovarian granulosa cells (GCs). Although autophagy (a cellular quality-control mechanism) and ferroptosis …
Type 1 diabetes (T1D) is a chronic metabolic disease characterized by impaired glucose homeostasis and persistent hyperglycemia. Drosophila has emerged as a valuable model to study conserved insulin signaling mechanisms; proteomic insights into T1D-like conditions …
Researchers analyzed sleep duration against 23 biological aging markers across multiple organ systems and found a U-shaped pattern: both too little (<6 hours) and too much (>8 hours) sleep are linked to faster biological aging, …
BACKGROUND: Successful aging (SA) is a key focus in gerontological research, highlighting the importance of maintaining physical, cognitive, and social well-being. Nutrition is a critical determinant of health in older adults, and sustainable healthy eating …
This collection brings together 16 studies from researchers worldwide showing that circadian rhythms—your body's 24-hour internal clock—play a central role in aging and longevity. By understanding how these rhythms break down with age, scientists are …
Researchers conducted an intensive year-long self-study (N=1) combining time-restricted eating, exercise, Mediterranean diet, and continuous biomarker monitoring to assess how well a healthy person's body adapts to stress. The study demonstrates new methods for tracking …
Age-related circadian disruptions accelerate physiological decline and shorten lifespan. Enhancing circadian amplitude has emerged as a promising strategy for ameliorating age-associated disorders. Here, we show that the circadian-phase-optimized administration of 3'-deoxyadenosine (3dA) strengthens circadian amplitude …
Disruption of the circadian clock as well as reduced NAD+ levels are both hallmarks of aging. While circadian rhythms and NAD+ metabolism have been linked in heart disease, their relationship during cardiac aging is less …
Cerebral oxygen extraction fraction (OEF) reflects the balance between cerebral oxygen delivery and metabolic demand, but its normative evolution across the human lifespan remains unknown. Here we used rapid, non-contrast TRUST MRI to establish a …