Human clinical trials testing longevity interventions
BACKGROUND: Deep-plane facelift (DPF) and its extended modification (EDPF) have been developed to address age-related changes in the lower face, particularly marionette lines, jowls, and neck laxity. Although both techniques provide durable rejuvenation, direct comparative …
This study investigated foliar-applied Lactic Acid Bacteria (LAB) as a biostimulant to enhance postharvest resilience and quality of tomato (Solanum lycopersicum L.) fruit under drought stress. A randomized greenhouse experiment was conducted with four treatments: …
Almost a century ago, calorie restriction (CR) was identified as a robust intervention for extending lifespan and healthspan, a discovery that captured the imagination of both scientists and the public. If the powerful mechanisms engaged …
BACKGROUND: Skin thinning, known as dermatoporosis, is an expected consequence of aging that involves structural weaknesses, barrier deficiencies, and cellular senescence, posing challenges for maintaining long-term skin health. OBJECTIVE: To introduce Skin Activation as a …
This review examines how immunosenescence (age-related immune decline) drives lung diseases like COPD, fibrosis, and cancer, and surveys emerging treatments including senolytics, stem cell therapy, and lifestyle interventions. While it synthesizes current knowledge well, it's …
Researchers studied 3,703 adults over 90 and 22,354 younger adults to identify genetic variants linked not just to living longer, but to living longer *well*. They found that certain genes (APOE, APOC1) are associated with …
A major clinical trial tracked 864 different metabolites in people doing long-term caloric restriction and found distinct shifts in carbohydrate and fat metabolism—with early changes during weight loss giving way to compensatory responses during weight …
In a study of 1,545 Chinese people aged 80+, researchers found that maintaining healthy lifestyle factors reduced death risk by 41% and added nearly 7 years of life—even more than genetic advantages. Importantly, good genes …
PURPOSE: To clinically evaluate dermal thickness, pores, and wrinkles after using Profhilo® in perioral regions. MATERIALS AND METHODS: This split-face study included 12 female participants aged 45 to 65 with visible signs of perioral aging. …
Researchers used artificial intelligence to analyze ECGs and calculate a person's cardiac "biological age"—how old their heart appears versus their calendar age. They found that people whose hearts looked older than they actually were had …
This review paper synthesizes what we know about why people in five Blue Zone regions (Okinawa, Sardinia, Nicoya Peninsula, Ikaria, Loma Linda) live exceptionally long lives with low heart disease rates. The authors propose that …
Researchers tested injectable forms of nicotinamide riboside (NR), a compound that boosts NAD+ levels, in two small Phase 1 trials with 84 total participants. The injections were well-tolerated with no serious safety concerns, though some …
Bioactive peptides have become increasingly common ingredients in skincare products and procedural adjuncts in aesthetic practices. Modeled after naturally occurring matrikines, these short amino acid chains are designed to influence the extracellular matrix (ECM), cellular …
Frailty, a syndrome that decreases healthspan in older individuals, lacks effective therapies. We conducted a randomized, dose-finding clinical trial to test whether human bone marrow-derived allogeneic mesenchymal stem cells (MSCs; laromestrocel) improve physical functioning and …
BackgroundGeroprotective interventions, including the mTOR inhibitor rapamycin, slow aging in preclinical models. Translation to humans remains challenging because clinical trials require endpoints detectable within feasible timeframes. Multi-modal in vivo imaging could address this limitation by …
Radiotherapy-induced skin fibrosis is a chronic progressive complication of radiotherapy that impairs function, aesthetics, and quality of life yet remains under-recognized and undertreated. While acute cutaneous toxicities are typically transient, chronic sequelae such as fibrosis, …
Despite optimal lipid-lowering treatment, numerous older adults with atherosclerotic cardiovascular disease continue to experience progression driven by inflammation, referred to as residual inflammatory risk. Cellular senescence and the senescence-associated secretory phenotype (SASP) significantly contribute to …
Telomere length is increasingly used as a proxy for an aging exposome", an index of non-genetic environmental (and behavioral) exposures that an individual encounters, leading to differences in rates of aging. One of the largest …
Exosomes are secreted tiny organelles that are single-membrane enclosed and can perform a broad spectrum of functions upon release, such as the reorganization of extracellular matrix and communication with other cells through the release of …
BACKGROUND: In animal models, caloric restriction (CR) and time-restricted eating (TRE) extend lifespan and healthspan; however, the long-term benefits in humans are unknown. The goal of the Health, Aging and Later-Life Outcomes Pilot (HALLO-P) was …