Human clinical trials testing longevity interventions
OBJECTIVE: To evaluate the effectiveness of high-frequency microneedling (HFM) using a layering technique versus conventional HFM for facial rejuvenation, with the Fitzpatrick Wrinkle and Laxity Classification Scale (FWCS) score at 3 months post-treatment as the …
BACKGROUND: Deep-plane facelift (DPF) and its extended modification (EDPF) have been developed to address age-related changes in the lower face, particularly marionette lines, jowls, and neck laxity. Although both techniques provide durable rejuvenation, direct comparative …
This review examines how immunosenescence (age-related immune decline) drives lung diseases like COPD, fibrosis, and cancer, and surveys emerging treatments including senolytics, stem cell therapy, and lifestyle interventions. While it synthesizes current knowledge well, it's …
INTRODUCTION: This study evaluates a novel lidocaine-premixed hyaluronic acid (HA) gel for nasolabial fold (NLF) correction, addressing pain management and longevity challenges in facial rejuvenation. The aim is to assess the non-inferiority, efficacy, and safety …
Tauopathies are neurodegenerative diseases characterized by the presence of hyperphosphorylated tau (p-tau) and neurofibrillary tangles. Autophagy is a critical self-degradation mechanism that preserves cellular homeostasis and function, including the clearance of misfolded proteins. Autophagy is …
This review paper synthesizes what we know about why people in five Blue Zone regions (Okinawa, Sardinia, Nicoya Peninsula, Ikaria, Loma Linda) live exceptionally long lives with low heart disease rates. The authors propose that …
Cellular senescence, a key feature of ageing, involves irreversible cell cycle arrest and the secretion of pro-inflammatory senescence-associated secretory phenotype (SASP) factors, which contribute to tissue degeneration and age-related diseases. Targeting senescent cells with senolytics, …
A major clinical trial tracked 864 different metabolites in people doing long-term caloric restriction and found distinct shifts in carbohydrate and fat metabolism—with early changes during weight loss giving way to compensatory responses during weight …
What is the ultimate goal of biogerontology (the study of the biology of aging)? A fashionable answer these days, often encountered, is that it is to extend healthspan not lifespan. Here we argue that this …
To investigate the age-related anatomical, structural, and functional changes occurring in the human nose, and to evaluate the most effective surgical techniques utilized for structural rejuvenation and airway restoration in older patients. A comprehensive narrative …
BACKGROUND: Asian Indians exhibit disproportionately high rates of prediabetes progression to type 2 diabetes, associated with accelerated biological aging. Metformin has been proposed to exert anti-aging effects independent of glycemic control; however, adequately powered randomized …
The Bacillus Calmette-Guérin (BCG) vaccine, a live-attenuated derivative of Mycobacterium bovis, has long been central to global tuberculosis prevention. Although it protects well against severe childhood TB, its efficacy against adult pulmonary TB is variable. …
BACKGROUND: Current barriers to achieving radical life extension include the inability to use syngeneic, youthful mesenchymal stem cells (MSCs) and the anti-regenerative effects of senescence-associated secretory phenotype (SASP) factors. We aim to overcome this by …
Frailty, a syndrome that decreases healthspan in older individuals, lacks effective therapies. We conducted a randomized, dose-finding clinical trial to test whether human bone marrow-derived allogeneic mesenchymal stem cells (MSCs; laromestrocel) improve physical functioning and …
Radiotherapy-induced skin fibrosis is a chronic progressive complication of radiotherapy that impairs function, aesthetics, and quality of life yet remains under-recognized and undertreated. While acute cutaneous toxicities are typically transient, chronic sequelae such as fibrosis, …
Researchers studied 3,703 adults over 90 and 22,354 younger adults to identify genetic variants linked not just to living longer, but to living longer *well*. They found that certain genes (APOE, APOC1) are associated with …
Heterochronic parabiosis improves physiological and cognitive function in aging rodents; these benefits appear to be derived from the removal of aged blood plasma components and the addition of younger ones. In humans, removing plasma from …
PURPOSE: To clinically evaluate dermal thickness, pores, and wrinkles after using Profhilo® in perioral regions. MATERIALS AND METHODS: This split-face study included 12 female participants aged 45 to 65 with visible signs of perioral aging. …
Almost a century ago, calorie restriction (CR) was identified as a robust intervention for extending lifespan and healthspan, a discovery that captured the imagination of both scientists and the public. If the powerful mechanisms engaged …
BACKGROUND: Facial aging is a multilayered process involving the skin, subcutaneous tissue, and facial musculature. OBJECTIVE: To evaluate the efficacy and safety of an integrated radiofrequency (RF), microneedle radiofrequency (MNRF), and dynamic muscle stimulation (DMSt) …