Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans
Monocytes and macrophages are critically involved in the pathogenesis of atherosclerotic cardiovascular disease (ASCVD). Accumulating evidence indicates that monocytes and macrophages can develop innate immune memory and exhibit sustained pro-inflammatory properties in response to stimuli …
Researchers tested whether an FDA-approved HIV medication (tenofovir alafenamide) could slow aging in healthy people by suppressing harmful retrotransposons. Over 12 weeks, the drug showed measurable reductions in epigenetic aging markers, but this is preliminary …
Telomere biology disorders (TBDs) are characterized by bone marrow failure (BMF) and dysfunctional telomeres. So far, inherited mutations in 18 genes have been identified in TBDs. Here, we describe a child presenting with early BMF, …
PURPOSE: Aberrant enhancer dynamics play a critical role in the initiation and progression of colorectal cancer (CRC), particularly in the BRAFV600E-mutated metastatic subtype, which uniquely exhibits a strong epigenetic phenotype. Building on this epigenetic vulnerability, …
This is a protocol paper describing an upcoming clinical trial that will test whether three drugs (metformin, fisetin, and spermidine) can reduce senescent cells and reverse aging hallmarks in healthy adults over 70 within three …
Researchers tested whether replacing a patient's blood plasma with plasma from young, healthy donors could slow cognitive decline in early Alzheimer's disease. In 12 patients, the procedure proved safe and feasible, though this early-stage study …
The prevalence of major depressive disorder (MDD) is increasing globally, particularly among adolescents. Although gut-brain axis dysfunction has been implicated in adolescent depression, the mechanisms by which gut microbiota dysbiosis drives depressive behaviors and potential …
BACKGROUND: Upper eyelid crease morphology is a critical determinant of periorbital aesthetics. In Asian patients, anatomic variations in levator aponeurosis insertion and preaponeurotic fat distribution frequently result in crease asymmetry or attenuation, particularly in mild-to-moderate …
Submandibular gland prominence can undermine aesthetic outcomes in neck and lower face rejuvenation, even after deep-plane facelifts and platysmaplasty. In selected patients, gland reduction has emerged as an effective adjunct to improve cervicomental contour. In …
Epstein-Barr virus-associated gastric cancer (EBVaGC) accounts for ~9% to 10% of gastric cancers worldwide and is defined by a distinctive molecular profile, including extreme hypermethylation of the DNA. Targeting this aberrant methylation may be a …
BACKGROUND: Autophagy genes are essential for proper uterine function, reproductive physiology, and the maintenance of endometrial atrophy (EA). OBJECTIVE: This study aims to clarify how these genes impact endometrial thickness and their significance in the …
This retrospective single-surgeon series evaluated a composite lower-eyelid rejuvenation technique that combines a transconjunctival, door-shaped orbital septal fat flap with granular autologous fat precision grafting. Consecutive patients treated between June 2024 and February 2025 were …
BACKGROUND: Lupus nephritis (LN), a severe complication of systemic lupus erythematosus (SLE), is characterized by glomerular endothelial cell injury, inflammation, and immune complex deposition. The 14-3-3η protein, a multifunctional regulator, plays roles in various cellular …
Calcium hydroxylapatite (CaHA) has evolved from hard tissue applications to become a prospective bioactive filler for facial rejuvenation, offering both immediate volumization and long-term regenerative benefits. This review synthesizes literature up to 2025 to summarize …
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a dismal 5‑year survival rate of ~9%, primarily due to late diagnosis, aggressive metastasis and profound resistance to conventional therapies. Epithelial‑mesenchymal transition (EMT) …
Polycystic ovary syndrome (PCOS) is a highly heterogeneous endocrine-metabolic disorder whose core pathological features-follicular atresia and ovulatory dysfunction-are attributed to functional failure of ovarian granulosa cells (GCs). Although autophagy (a cellular quality-control mechanism) and ferroptosis …
The development of geroprotectors, compounds that slow the biological aging process, is an important goal in modern medicine. These interventions hold the promise not only of extending lifespan, but more importantly, of extending healthspan-the period …
A small clinical trial found that bezisterim, an experimental anti-inflammatory drug, reduced epigenetic markers of aging and was associated with changes in genes linked to brain inflammation and cognitive decline. However, this is early-stage work …
Facial thread lifting is a popular, minimally invasive procedure for facial rejuvenation. While most complications are mild and self-limiting, severe adverse events may occur rarely. Injury to the parotid gland or its ducts represents a …
Facial laxity is a major aesthetic concern, often managed through energy-based skin-tightening devices. However, safety considerations arise when treating patients with atopic dermatitis (AD), due to barrier dysfunction, and in those with prior aesthetic procedures, …