Existing drugs repurposed for anti-aging applications
BACKGROUND: PDGFRA genetic alterations are a well-established oncogenic driver in gliomas. However, targeted monotherapy against PDGFRA such as avapritinib has achieved limited clinical efficacy, and the mechanism underlying avapritinib resistance remains poorly understood. METHODS: Multi-omics …
Exosomes are secreted tiny organelles that are single-membrane enclosed and can perform a broad spectrum of functions upon release, such as the reorganization of extracellular matrix and communication with other cells through the release of …
Aging poses a growing global health burden, creating an urgent need for effective interventions. This study reveals that fenofibrate, a clinically approved drug for hyperlipidemia, exerts significant anti-aging effects by targeting fundamental aging processes. We …
Cytomegalovirus (CMV), a virus that infects most people with HIV, accelerates aging and inflammation even when HIV is suppressed by medication. Recent studies show that antiviral drugs and vaccines may reverse some of this damage, …
Researchers tested whether an FDA-approved HIV medication (tenofovir alafenamide) could slow aging in healthy people by suppressing harmful retrotransposons. Over 12 weeks, the drug showed measurable reductions in epigenetic aging markers, but this is preliminary …
Researchers found that terbinafine (an antifungal) and miglustat (a diabetes drug) activate mitochondrial stress responses that extended lifespan and improved health markers in C. elegans worms and human cells. The discovery suggests these existing drugs …
A protein called klotho, known to extend lifespan and boost brain function, appears to protect people with Parkinson's disease from cognitive decline—at least in genetic studies and mouse models. Researchers found that higher klotho levels …
Researchers analyzed 5.15 million people with type 2 diabetes across multiple countries to see if four common second-line diabetes drugs worked differently in women versus men. They found no sex differences in heart protection, but …
Researchers found that losartan, a common blood pressure medication, shifted the metabolic fingerprint of aged mice and pre-frail older men toward a younger state. The effect appeared dose-dependent in humans and required functional angiotensin II …
Researchers gave middle-aged mice metformin and then exposed them to heart stress. Metformin-treated mice showed better cardiac function and healthier mitochondria (the cell's energy factories) compared to untreated mice. This suggests metformin might help hearts …
Almost a century ago, calorie restriction (CR) was identified as a robust intervention for extending lifespan and healthspan, a discovery that captured the imagination of both scientists and the public. If the powerful mechanisms engaged …
Researchers used AI agents to reanalyze millions of existing molecular datasets (methylation and RNA sequencing) through the lens of aging clocks, discovering over 500 interventions that appear to reduce biological age—including drugs like ouabain and …