FDA/EMA pathways and regulatory frameworks for aging interventions
BACKGROUND: Facial aging results from genetic, environmental, and lifestyle factors, leading to wrinkles, volume loss, and contour changes. These alterations affect perceived age, attractiveness, and self-image. Eye-tracking technology provides insights into gaze patterns, revealing how …
Males and females are known to have dramatically different health and lifespan trajectories, but the underlying basis for these differences is yet to be fully elucidated. In the Caenorhabditis elegans nematode model system, most aging …
In this study, we examined resident preferences for prospective end-of-life management of a coastal wind farm in Japan through a case study of an 11-turbine, 22 MW installation, based on a questionnaire survey of 218 …
The bone marrow niche (BMN) plays a central role in regulating hematopoietic stem-cell (HSC) maintenance, lineage commitment, and immune homeostasis, while also supporting osteogenesis and maintaining skeletal integrity. Once considered static, the BMN is now …
Researchers found that corylin, a flavonoid from a traditional medicinal plant, extended lifespan and improved stress resistance in C. elegans worms by activating two key proteins that enhance cellular housekeeping and mitochondrial health. While promising, …
Cellular senescence, a key feature of ageing, involves irreversible cell cycle arrest and the secretion of pro-inflammatory senescence-associated secretory phenotype (SASP) factors, which contribute to tissue degeneration and age-related diseases. Targeting senescent cells with senolytics, …
INTRODUCTION: Skin aging, marked by wrinkles, volume loss, and reduced hydration, has driven growing interest in minimally invasive aesthetic treatments to restore skin quality and appearance. This study aimed to evaluate the efficacy and safety …
Classic psychedelics such as lysergic acid diethylamide (LSD), psilocybin, N,N-dimethyltryptamine (DMT), and mescaline induce lasting changes in neuroplasticity and behavior that extend far beyond their acute pharmacological effects. Emerging evidence highlights that these enduring therapeutic …
AIMS: Numerous preclinical studies suggested that targeted inhibition of mammalian target of rapamycin (mTOR) may be beneficial for the treatment of osteoporosis. However, the relevance of these findings to human populations remains unclear. We hypothesized …
Cancer progression and treatment failure are driven not only by genetic alterations but also by the remarkable capacity of tumor cells to adapt to metabolic stress, immune surveillance, and therapeutic pressure. Epigenetic plasticity provides a …
Extracellular vesicles (EVs) are membrane-enclosed nanoparticles that mediate intercellular communication by transferring proteins, nucleic acids, and lipids. Within the hematopoietic system, EVs orchestrate critical signaling between bone marrow (BM) niche cells and hematopoietic stem and …
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related deaths worldwide, highlighting the urgent requirement for innovative therapeutic strategies. Cytisine N-methylene-(4',5,7-trihydroxy)-isoflavone (named CNI3), a natural derivative of cytisine N-isoflavone isolated from Sophora alopecuroides …
Cardiac regeneration is limited in the adult mammalian heart because of restricted cardiomyocyte proliferation and persistent fibrosis. We previously demonstrated that transient pharmacological inhibition of succinate dehydrogenase (SDH) with malonate promotes regeneration after myocardial infarction. …
BACKGROUND: Poly-L-lactic acid (PLLA) is a biostimulatory injectable that restores midfacial volume through collagen neogenesis rather than gel-based filling. Controlled clinical evidence directly quantifying PLLA's volumetric efficacy remains limited. OBJECTIVES: To evaluate the efficacy, safety, …
The health risks of polypropylene plastic, a major food-grade polymer, are often underestimated. Current evidence indicates that infants and young children may ingest millions of polypropylene microplastic particles (PP-MPs) daily, accompanied by co-exposure to di(2-ethylhexyl) …
The actin cytoskeleton is a fundamental and highly conserved structure that functions in diverse cellular processes, yet its direct contribution to organismal aging remains unclear. Here, we systematically interrogated how genetic and pharmacologic perturbations of …
Background The 2026 multisociety guideline frames cardiovascular, kidney, and metabolic health as a staged pathway. National surveillance should distinguish early-risk expansion from advanced-disease accumulation because they require different responses. Methods We analysed 66,553 adults aged …
Therapeutic resistance is the main obstacle to long‑term survival in lung cancer, with metabolic reprogramming identified as a key factor in this failure. Accumulating evidence suggests that metabolic reprogramming, particularly the aberrant metabolism of lactate, …
PURPOSE: Spermidine administration ameliorates hepatic steatosis and cardiometabolic dysfunction in animal models. However, evidence in humans remains limited. We aimed to explore the 1-year longitudinal associations between changes in dietary spermidine intake and changes in …
Researchers gave aging mice rapamycin and found it prevented the normal decline in movement and motor control, with females benefiting more than males. The benefits appear linked to reduced oxidative stress and cellular stress in …