Compounds that protect against age-related damage and disease
Almost a century ago, calorie restriction (CR) was identified as a robust intervention for extending lifespan and healthspan, a discovery that captured the imagination of both scientists and the public. If the powerful mechanisms engaged …
Researchers isolated a fructan sugar compound (PKP-1b) from a traditional Chinese medicinal plant and found it extended lifespan and reduced aging signs in C. elegans and mice by dampening insulin/IGF-1 signaling—a well-known aging pathway. While …
Researchers found that a polysaccharide extract from Polygonatum sibiricum (a traditional medicinal herb) slowed aging and preserved muscle strength in C. elegans worms by reducing oxidative stress and stabilizing mitochondria. Crucially, these benefits depended entirely …
This comprehensive review identifies 12 hallmarks of how the heart and blood vessels age at molecular, cellular, and systemic levels—from DNA damage to inflammation to stem cell exhaustion. The authors map out current FDA-approved drugs …
This review examines FOXO4-DRI, a designed peptide that kills senescent (aged) cells by disrupting a protein interaction linked to brain aging. Animal studies show it improves memory and reverses some Alzheimer's-like damage, while early human …
Researchers tested whether replacing a patient's blood plasma with plasma from young, healthy donors could slow cognitive decline in early Alzheimer's disease. In 12 patients, the procedure proved safe and feasible, though this early-stage study …
Researchers tested injectable forms of nicotinamide riboside (NR), a compound that boosts NAD+ levels, in two small Phase 1 trials with 84 total participants. The injections were well-tolerated with no serious safety concerns, though some …
This review challenges the assumption that senescent cells are always harmful, showing that some actually support healthy aging through wound healing and tissue maintenance. The authors propose a new strategy: prevent bad senescence while selectively …
Hypothesized to be a diet-derived 'longevity vitamin', Ergothioneine (ET) is increasingly recognized for its potential to modulate cellular homeostasis and support healthy ageing in preclinical models. This systematic review, encompassing evidence from 2005 to 2025, …
Organs age at different rates, yet the protective mechanisms contributing to decelerated aging in certain tissues remain unclear. Applying cross-tissue comparisons to molecular readouts of aging, here we report that the intervertebral disc (IVD) ages …
Researchers compared gut bacteria in people aged 45–59, 60–89, and 90+ and found that centenarians have distinctly different microbial communities—richer in beneficial bacteria like Akkermansia and enriched in pathways that produce fatty acids and other …
Researchers identified a liver-derived protein called GPLD1 that transfers exercise's cognitive benefits to the brain by targeting blood vessel dysfunction. In aging and Alzheimer's mouse models, boosting GPLD1 or blocking its downstream target TNAP restored …
This review examines whether infusing young plasma can rejuvenate aging bodies, a concept supported by animal experiments but largely unproven in humans. The authors argue that while preclinical models show promise, current clinical applications of …
A small clinical trial found that bezisterim, an experimental anti-inflammatory drug, reduced epigenetic markers of aging and was associated with changes in genes linked to brain inflammation and cognitive decline. However, this is early-stage work …
Researchers found that an ethanol extract from Salvia plebeia plant enhanced autophagy (cellular garbage disposal) and reversed senescence markers in cell culture and aged mice, with rosmarinic acid identified as a key active ingredient. The …
Researchers found that corylin, a flavonoid from a traditional medicinal plant, extended lifespan and improved stress resistance in C. elegans worms by activating two key proteins that enhance cellular housekeeping and mitochondrial health. While promising, …
The development of geroprotectors, compounds that slow the biological aging process, is an important goal in modern medicine. These interventions hold the promise not only of extending lifespan, but more importantly, of extending healthspan-the period …
Geroscience has the goal of extending lifespan through geroprotective interventions. These interventions are typically imparted on groups of individuals, with their efficacy judged by increases in the average age-at-death. A more equitable outcome, which looks …
Epigenetic clocks are powerful biomarkers of biological aging, however, their performance varies across studies and contexts. Current limitations include siloed datasets, inconsistent validation methods, and the absence of a standardized framework for systematic comparison. Here, …
Pharmacological modulation of ageing is viewed as a viable route to extending lifespan and healthspan, yet the efficacy of putative geroprotectors may depend strongly on physiological and environmental context. Lithium chloride (LiCl) has been reported …