Geroprotectors — OutliveHub

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

Can metformin keep muscles and bones strong as we age?

Metformin might help middle-aged people stay strong and mobile longer, but we need human studies to be sure.

Researchers gave middle-aged mice metformin (a common diabetes drug) and found it slowed aging-related weakness, preserved muscle mass and strength, and maintained bone and joint health. The findings suggest metformin might be a cheap, widely-available …

Biogerontology

42 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

A plant compound slowed aging in worms and mice by tweaking metabolism

A plant extract slowed aging and brain decline in mice—but we don't yet know if it works in humans.

Researchers isolated a fructan sugar compound (PKP-1b) from a traditional Chinese medicinal plant and found it extended lifespan and reduced aging signs in C. elegans and mice by dampening insulin/IGF-1 signaling—a well-known aging pathway. While …

Carbohydrate polymers

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Review / Commentary PubMed

How Metformin May Slow Aging: Mechanisms and Evidence

Metformin, a cheap diabetes drug, might slow aging, but we need stronger proof before recommending it to everyone.

This review examines how metformin, a common diabetes drug, may have anti-aging properties by activating cellular stress-response pathways (AMPK), reducing inflammation, and improving mitochondrial function. While observational studies and mechanistic evidence are promising, the authors …

Molecular and cellular endocrinology

40 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins Review / Commentary PubMed

How We're Moving From Understanding Aging to Actually Treating It

Scientists are shifting from just describing aging to actually figuring out how to slow or reverse it using drugs and personalized medicine.

The 12th Aging Research and Drug Discovery conference brought together leading scientists to discuss a major shift in how we study aging—moving away from simply describing what goes wrong toward understanding the mechanisms we can …

Aging

36 Early

Promising Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Can a longevity protein protect Parkinson's patients from memory loss?

A protein that naturally extends lifespan might protect Parkinson's patients' thinking and memory, pointing to new treatments.

A protein called klotho, known to extend lifespan and boost brain function, appears to protect people with Parkinson's disease from cognitive decline—at least in genetic studies and mouse models. Researchers found that higher klotho levels …

The Journal of neuroscience : the official journal of the Society for Neuroscience

53 Promising

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How aging cells slow wound healing in diabetes—and new treatments that might help

Clearing out old damaged cells might help diabetic wounds heal better and reduce serious complications.

This review examines how senescent (aged) cells impair diabetic wound healing by triggering chronic inflammation. The authors discuss emerging drugs called senolytics that clear these harmful cells, suggesting a new therapeutic approach to treating stubborn …

Journal of biochemistry

33 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … In Vitro PubMed

Five new plant alkaloids extend lifespan in worms by up to 9%

Plant compounds that might slow aging were found, but they've only been tested in worms, not people yet.

Researchers isolated five previously unknown alkaloid compounds from a plant called Benstonea parva and tested them in C. elegans worms. Four of the compounds extended lifespan by up to 9%, suggesting these plant molecules may …

Phytochemistry

39 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Astaxanthin, meclizine, mitoglitazone, pioglitazone, alpha-ketoglutarate, mifepristone, methotrexate, and atorvastatin-telmisartan do not increase lifespan in UM-HET3 mice.

The Interventions Testing Program (ITP) evaluated eleven compounds in genetically heterogeneous UM-HET3 mice to assess their potential to extend lifespan. These interventions included both novel agents and previously tested compounds administered at novel doses or …

GeroScience

44 Early

Preliminary Biomarkers — Aging clocks and measurement tools Observational PubMed

Gut Bacteria Linked to Living Past 90: What Their Microbiomes Reveal

Researchers compared gut bacteria in people aged 45–59, 60–89, and 90+ and found that centenarians have distinctly different microbial communities—richer in beneficial bacteria like Akkermansia and enriched in pathways that produce fatty acids and other …

Applied microbiology and biotechnology

44 Early

Promising Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

Exercise's Brain-Boosting Molecule Reverses Memory Loss by Cleaning Up Blood Vessels

Researchers identified a liver-derived protein called GPLD1 that transfers exercise's cognitive benefits to the brain by targeting blood vessel dysfunction. In aging and Alzheimer's mouse models, boosting GPLD1 or blocking its downstream target TNAP restored …

Cell

59 Promising

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Review / Commentary PubMed

Can Young Blood Make You Younger? What Science Actually Shows (and Doesn't)

This review examines whether infusing young plasma can rejuvenate aging bodies, a concept supported by animal experiments but largely unproven in humans. The authors argue that while preclinical models show promise, current clinical applications of …

GeroScience

41 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Randomised Controlled Trial medRxiv

Can bezisterim slow brain aging in Alzheimer's disease?

A small clinical trial found that bezisterim, an experimental anti-inflammatory drug, reduced epigenetic markers of aging and was associated with changes in genes linked to brain inflammation and cognitive decline. However, this is early-stage work …

medrxiv (preprint)

31 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

Plant extract Salvia plebeia triggers cellular cleanup and reverses aging signs in mice

Researchers found that an ethanol extract from Salvia plebeia plant enhanced autophagy (cellular garbage disposal) and reversed senescence markers in cell culture and aged mice, with rosmarinic acid identified as a key active ingredient. The …

The Journal of nutritional biochemistry

41 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

A Natural Plant Compound Slows Aging in Worms by Boosting Cellular Cleanup

Researchers found that corylin, a flavonoid from a traditional medicinal plant, extended lifespan and improved stress resistance in C. elegans worms by activating two key proteins that enhance cellular housekeeping and mitochondrial health. While promising, …

Journal of ethnopharmacology

41 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

A new compound that extends the lifespan of worms, with favorable in vitro properties and a lack of toxicity in rodents.

The development of geroprotectors, compounds that slow the biological aging process, is an important goal in modern medicine. These interventions hold the promise not only of extending lifespan, but more importantly, of extending healthspan-the period …

RSC medicinal chemistry

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

No evidence for squaring the survival curve: lifespan-extending treatments increase variation in age- at-death.

Geroscience has the goal of extending lifespan through geroprotective interventions. These interventions are typically imparted on groups of individuals, with their efficacy judged by increases in the average age-at-death. A more equitable outcome, which looks …

Biology letters

38 Early

Preliminary Biomarkers — Aging clocks and measurement tools Other bioRxiv

TranslAGE: A Comprehensive Platform for Systematic Validation of Epigenetic Aging Biomarkers

Epigenetic clocks are powerful biomarkers of biological aging, however, their performance varies across studies and contexts. Current limitations include siloed datasets, inconsistent validation methods, and the absence of a standardized framework for systematic comparison. Here, …

biorxiv (preprint)

34 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

No evidence lithium supplementation extends lifespan in male Drosophila melanogaster.

Pharmacological modulation of ageing is viewed as a viable route to extending lifespan and healthspan, yet the efficacy of putative geroprotectors may depend strongly on physiological and environmental context. Lithium chloride (LiCl) has been reported …

Biogerontology

44 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other medRxiv

Multi-modal and multi-organ in vivo imaging to assess geroprotective interventions in humans: results from a pilot trial of rapamycin in Alzheimer's Disease

BackgroundGeroprotective interventions, including the mTOR inhibitor rapamycin, slow aging in preclinical models. Translation to humans remains challenging because clinical trials require endpoints detectable within feasible timeframes. Multi-modal in vivo imaging could address this limitation by …

medrxiv (preprint)

34 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

Plant polysaccharide delays muscle aging in worms by activating a key longevity pathway

A plant compound may slow muscle aging by activating the same longevity pathway that makes caloric restriction work—but only in worms so far.

Researchers found that a polysaccharide extract from Polygonatum sibiricum (a traditional medicinal herb) slowed aging and preserved muscle strength in C. elegans worms by reducing oxidative stress and stabilizing mitochondria. Crucially, these benefits depended entirely …

International journal of biological macromolecules

36 Early