Grip strength, gait speed, frailty indices, and physical function
Researchers identified a quantitative framework showing that aging proceeds in two distinct phases: a stable period followed by a transition to frailty marked by intestinal breakdown. They found that newly frail individuals face extreme early …
Researchers found that female fruit flies on very low-cholesterol diets had shorter lifespans and developed leaky gut problems. Interestingly, not all flies showed gut damage before dying, suggesting cholesterol may be essential for maintaining intestinal …
This editorial argues that biogerontology has been too focused on extending lifespan (how long we live) without clearly defining what healthspan (how well we live) actually means. The author proposes that healthspan should be understood …
Researchers tested 16 different biomarkers of aging (epigenetic clocks, blood proteins, telomeres, and others) in over 1,000 people tracked for 7 years. Two markers—Allostatic Load Index and DunedinPACE—stood out as the most reliable predictors of …
Researchers tested 14 different epigenetic clocks (DNA methylation–based age measures) in over 1,000 older adults and found that DunedinPACE, a newer clock, consistently predicted cognitive decline better than older clocks. This suggests DunedinPACE may be …
Cytomegalovirus (CMV), a virus that infects most people with HIV, accelerates aging and inflammation even when HIV is suppressed by medication. Recent studies show that antiviral drugs and vaccines may reverse some of this damage, …
Researchers enrolled 209 companion dogs in a 30-month study to identify biomarkers of aging that could make dogs a better translational model for human longevity research. Early findings show consistent age-related changes in blood work, …
Gut microbiota resilience, the capacity of intestinal microbial communities to resist, adapt, and recover from perturbations has emerged as a critical determinant of human health and longevity. Environmental stressors such as antibiotics, pollutants, poor diet, …
As the global population over age 65 is projected to triple by 2050, understanding the physiological mechanisms of aging and the role of sex as a biological variable (SABV) is critical. Research conducted on old …
Ageing biomarkers can predict mortality risk beyond chronological age. Recently, plasma proteins were used to estimate the biological ages of eleven human organs, including the brain, heart, liver, kidneys, and pancreas. Accelerated organ ageing is …
BACKGROUND: In many countries, lifespan has been increasing faster than healthspan, leading to more years spent with late-life disease and highlighting the need for reliable biomarkers to measure biological aging. METHODS: We used data from …
Geriatricians have struggled to describe a complex and sometimes ambiguous professional identity. Unlike other medical specialties anchored in discrete organ systems, diagnostic and interventional technologies, or clearly defined clinical settings, geriatric medicine encompasses the care …
Population ageing has widened the gap between lifespan and healthspan, with frailty and functional dependence increasingly shaping late-life outcomes. Yet trajectories in older age remain highly heterogeneous, suggesting that vulnerability is not determined by chronological …
INTRODUCTION: GLP-1 receptor agonists (GLP-1RA) are glucose- and body weight-lowering therapies provided with cardio-renal benefits. Use of GLP-1RA in older adults with type 2 diabetes mellitus (T2DM) is increasing but concerns remain about their safety …
Background: Intrinsic capacity (IC) is a key marker of healthy ageing, which captures an individuals physical and mental capacities, measured across five domains: cognitive, locomotor, psychological, vitality, and sensory. Although genetic factors are known to …
Frailty, a syndrome that decreases healthspan in older individuals, lacks effective therapies. We conducted a randomized, dose-finding clinical trial to test whether human bone marrow-derived allogeneic mesenchymal stem cells (MSCs; laromestrocel) improve physical functioning and …
BACKGROUND: Birthweight readily measurable marker of fetal growth that may influence health across the lifespan. We aimed to investigate the potential causal association between birthweight and healthy aging and to identify the mediating roles of …
BACKGROUND: Population aging poses challenges to health systems and costs, and evidence shows that older adults spend a long time in ill health. Improving healthspan, time spent in good health, allows older adults to contribute …
Researchers found that lifelong restriction of valine, a branched-chain amino acid in protein, improved metabolic health and reduced aging markers in both male and female mice, but only extended lifespan in males by 23%. The …
This video presents rodent evidence that surgical visceral fat removal extends lifespan, then applies those findings to the creator's personal DEXA scan data showing he maintains unusually low visceral fat (127g vs. ~1300g expected for …