NAD+ / NMN — OutliveHub

Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

Vitamin K2 May Slow Aging in Worms by Protecting Mitochondria

Vitamin K2 might slow aging by protecting cell energy factories, but only worms have been tested so far.

Researchers found that vitamin K2 extended lifespan in C. elegans worms by reducing cellular stress and protecting mitochondria—the powerhouses of cells. The effect worked through a specific molecular pathway known to regulate aging. However, this …

Aging cell

42 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model PubMed

Boosting a Key Cellular Energy Molecule Extends Lifespan and Fights Alzheimer's in Flies

If true in humans, this could lead to treatments that slow aging and prevent Alzheimer's by fixing a cellular energy imbalance.

Researchers genetically modified fruit flies to increase a molecule called NAD+ specifically in their mitochondria (cellular power plants), and found this extended their lifespan and reversed Alzheimer's-like symptoms. This suggests that the NAD+/NADH balance is …

Aging and disease

42 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Animal Model PubMed

A plant compound slowed aging in worms and mice by tweaking metabolism

A plant extract slowed aging and brain decline in mice—but we don't yet know if it works in humans.

Researchers isolated a fructan sugar compound (PKP-1b) from a traditional Chinese medicinal plant and found it extended lifespan and reduced aging signs in C. elegans and mice by dampening insulin/IGF-1 signaling—a well-known aging pathway. While …

Carbohydrate polymers

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Review / Commentary PubMed

How a cellular energy molecule could slow kidney damage from diabetes

This research maps a potential drug target to slow kidney damage in diabetes, but human proof is still missing.

This review examines how NAD+ and a protein called SIRT3 control mitochondrial health in diabetic kidney disease, showing promising preclinical results but noting a critical gap: almost no human clinical evidence yet. If confirmed in …

Renal failure

36 Early

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary PubMed

How exercise activates SIRT1, a key aging-control protein

Exercise boosts a protein that fights aging signs. Understanding how could help us design better anti-aging workouts.

This review examines SIRT1, a protein activated by exercise that helps counteract multiple aging processes across the body. Evidence from animal and human studies shows different exercise types can boost SIRT1 levels in key organs, …

Biogerontology

40 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Randomised Controlled Trial bioRxiv

A New NAD+ Supplement Boosts Cells' Energy Without Raising Blood Levels

A new supplement formula delivers NAD+ into cells more efficiently, but we don't yet know if this translates to real health benefits.

Researchers tested a specially formulated NAD+ supplement (LNAD+) in a small randomized trial and found it rapidly increased NAD+ inside cells by 53% compared to placebo, while leaving blood NAD+ unchanged. The treatment was well-tolerated …

biorxiv (preprint)

34 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other medRxiv

Injectable Nicotinamide Riboside Shows Good Safety in Early Human Trials

Injectable NAD+ booster is safe to use, but we still don't know if it actually helps you live longer.

Researchers tested injectable forms of nicotinamide riboside (NR), a compound that boosts NAD+ levels, in two small Phase 1 trials with 84 total participants. The injections were well-tolerated with no serious safety concerns, though some …

medrxiv (preprint)

27 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Review / Commentary PubMed

Can boosting NAD+ reverse ovarian aging? What we know and don't know yet

This review examines NAD+—a crucial molecule for cellular energy and stress response—as a potential therapeutic target for age-related ovarian decline and disorders like polycystic ovary syndrome. The authors conclude that while NAD+ deficiency appears central …

Biology of reproduction

34 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … In Vitro PubMed

A Plant Compound Delays Aging in Cells by Activating Stress-Defense Pathways

Researchers found that 3,5-dicaffeoylquinic acid (3,5-diCQA), a compound from plants, delayed aging and improved stress resistance in worms and human cells by activating a well-known cellular defense pathway called SKN-1/Nrf2. The compound appears to work …

Food science & nutrition

40 Early

Preliminary AI & Computational — Machine learning in aging, drug discovery, protein folding, and digital twins In Vitro PubMed

How a NAD+ mimic activates the aging-linked SIR2 protein through internal communication networks

Researchers used computer simulations to map how a NAD+ analog activates SIR2, an enzyme linked to aging, by triggering a cascade of conformational changes that act like an internal relay system. They identified a previously …

PLoS computational biology

41 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Iridoids from the edible flowers of Rhododendron pachypodum: structural elucidation and healthspan related bioactivities in Caenorhabditis elegans.

Rhododendron pachypodum flowers are traditionally consumed by ethnic minorities in Yunnan as seasonal edible flowers, yet their bioactive iridoid constituents and associated biological activities remain underexplored. This study characterized the iridoid constituents and evaluated in …

Phytochemistry

38 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

Dietary restriction in aging and longevity.

Different types of dietary restriction (DR) have been practiced by humans for religious and medical purposes for millennia, but only during the past three decades has the scientific study of DR at cellular and molecular …

Nature aging

47 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other bioRxiv

Genomic Determinants of Phage Activity Against Pseudomonas aeruginosa: Roles of Receptors, Defence Systems, and Anti-Defences

Pseudomonas aeruginosa is a priority pathogen in chronic and multidrug-resistant infections, yet therapeutic phages targeting this organism often exhibit variable and unpredictable efficacy. A mechanistic understanding of the genomic determinants governing phage-host interactions is therefore …

biorxiv (preprint)

34 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Other PubMed

NAD+ controls circadian rhythmicity during cardiac aging.

Disruption of the circadian clock as well as reduced NAD+ levels are both hallmarks of aging. While circadian rhythms and NAD+ metabolism have been linked in heart disease, their relationship during cardiac aging is less …

Communications biology

38 Early

Preliminary Cellular — Research on cellular-level aging mechanisms In Vitro bioRxiv

How mitochondrial DNA variants affect telomere length in human cells

Researchers used lab-grown cells to show that mitochondrial DNA variants affecting energy production influence telomere length by controlling reactive oxygen species and NAD levels. This suggests that inherited mitochondrial traits may influence how quickly our …

biorxiv (preprint)

25 Early

Promising Biomarkers — Aging clocks and measurement tools Cohort Study PubMed

What makes centenarians tick? A metabolic fingerprint of extreme longevity

Researchers analyzed blood chemistry in 213 people over 100 years old and found they have distinctly different metabolic profiles—especially higher bile acids and lower inflammatory markers—compared to younger controls. By identifying these metabolic signatures, they …

GeroScience

51 Promising

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary PubMed

Combining Skin Treatments Inside and Out to Slow Aging

This explains why treating skin from inside and outside together might work better than either alone, but doesn't prove it actually does.

This review argues that combining topical skin treatments (retinoids, peptides, antioxidants) with internal supplements (NAD+ precursors, collagen peptides, polyphenols) can target multiple aging mechanisms simultaneously. While conceptually sound, the paper is a narrative review without …

Dermatology and therapy

32 Early

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Observational PubMed

Does Ginseng Slow Aging? A Small Study on Telomeres and Cellular Energy in Middle-Aged Adults

Researchers gave ginseng supplements to 50 overweight middle-aged adults in two groups and found associations with longer telomeres, higher NAD+ levels, and improvements in sleep and fatigue scores.

Researchers gave ginseng supplements to 50 overweight middle-aged adults in two groups and found associations with longer telomeres, higher NAD+ levels, and improvements in sleep and fatigue scores. However, the study is very small, lacks …

Journal of ethnopharmacology Feb 15, 2026

41 Early

Promising Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Review / Commentary YouTube

NMN & NAD Supplements: Debunking the Anti-Aging Hype with Science

Dr.

Dr. Brad Stanfield critically examines the NAD-boosting supplement trend, tracing it from compelling animal studies to disappointing human clinical trials and failed reproducibility attempts. He argues that despite initial excitement around NMN and NR supplements, …

Dr Brad Stanfield Feb 15, 2026

67 Promising

Preliminary Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary YouTube

Beta-Hydroxybutyrate: The Ketone Link to Longevity in Mice

Beta-hydroxybutyrate (BHB), a ketone body produced during ketogenic diets and caloric restriction, correlates with lifespan extension in mice and appears mechanistically linked to longevity through glucagon signaling.

Beta-hydroxybutyrate (BHB), a ketone body produced during ketogenic diets and caloric restriction, correlates with lifespan extension in mice and appears mechanistically linked to longevity through glucagon signaling. The video presents mouse model data showing BHB's …

Mike Lustgarten Feb 15, 2026

48 Early