Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ boosters, and the molecules in clinical trials right now.
Cellular metabolism is precisely regulated in response to nutrient availability. As an extremely energy-consuming anabolic process, ribosome biogenesis should be tightly controlled in response to nutrient supply. However, how the nucleolus responds to different nutrient …
Researchers found that purified compounds from goji berries (Lycium barbarum polysaccharides) extended the lifespan of C. elegans worms by about 21% and improved physical function, likely by activating ancient cellular stress-response pathways and altering how …
Biallelic pathogenic variants in STRADA (STE20-related adaptor alpha), an upstream regulator of the mechanistic target of rapamycin (mTOR) pathway, result in megalencephaly, drug-resistant epilepsy, and severe intellectual disability. This study explores how mTOR pathway hyperactivity …
Bisdemethoxycurcumin (BDMC) is a natural curcuminoid with higher solubility and stability than curcumin, yet its potential role in lifespan and healthspan regulation remains largely unexplored. This study aimed to investigate the effects of BDMC on …
Aging is a primary risk factor for disease progression in multiple sclerosis (MS). Because of this, treatments that can reduce the consequences of molecular aging, like senescence, have been proposed as a strategy to address …
Several if not all manifestations of aging can be postponed by a healthy lifestyle involving a balanced diet coupled with regular exercise and sufficient sleep. Similarly, various genetic and pharmacological longevity interventions can exert beneficial …
Researchers found that a polysaccharide extract from Polygonatum sibiricum (a traditional medicinal herb) slowed aging and preserved muscle strength in C. elegans worms by reducing oxidative stress and stabilizing mitochondria. Crucially, these benefits depended entirely …
Twenty years have passed since the first demonstration of mouse induced pluripotent stem cells (iPSCs). What began as an unexpected observation in Kyoto quickly transformed stem cell biology and regenerative medicine worldwide. Over the past …
Researchers found that D-pinitol, a naturally occurring compound from plants, extended the lifespan of C. elegans worms by nearly 29% while improving muscle function and reducing cellular aging markers. The compound works by activating multiple …
Researchers tested seven compounds known to slow aging in hermaphrodite worms on male worms and found that all extended lifespan, but only sulforaphane and metformin improved reproductive function in older males. This suggests that living …
BACKGROUND: Hepatocellular carcinoma (HCC) is characterized by high recurrence rates and limited targeted therapies. Centromere protein I (CENPI), a core kinetochore component linked to chromosomal instability, is dysregulated in multiple malignancies, yet its role and …
Aging poses a growing global health burden, creating an urgent need for effective interventions. This study reveals that fenofibrate, a clinically approved drug for hyperlipidemia, exerts significant anti-aging effects by targeting fundamental aging processes. We …
The increasing global burden of age-related diseases necessitates interventions that target the unified biological processes of aging, as outlined by the expanding framework of fourteen interconnected hallmarks. This review establishes nicotinamide adenine dinucleotide (NAD⁺) as …
Researchers found that corylin, a flavonoid from a traditional medicinal plant, extended lifespan and improved stress resistance in C. elegans worms by activating two key proteins that enhance cellular housekeeping and mitochondrial health. While promising, …
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with few effective treatment options. While metabolic reprogramming has been associated with IPF, the precise mechanisms connecting mitochondrial metabolic dysfunction to epigenetically driven fibrogenesis …
Researchers gave middle-aged mice metformin (a common diabetes drug) and found it slowed aging-related weakness, preserved muscle mass and strength, and maintained bone and joint health. The findings suggest metformin might be a cheap, widely-available …
Researchers fed pregnant fruit flies a high-fat diet supplemented with tauroursodeoxycholic acid (TUDCA), a bile acid derivative, and found their offspring lived ~19% longer with better stress resistance and mitochondrial health. The lifespan benefit depended …
Mechanistic target of rapamycin (mTOR) is a key protein kinase that integrates various internal and external signals to control biological events including cell growth. Whereas substantial efforts were made to elucidate protein subunits interacting with …
This review examines NAD+—a crucial molecule for cellular energy and stress response—as a potential therapeutic target for age-related ovarian decline and disorders like polycystic ovary syndrome. The authors conclude that while NAD+ deficiency appears central …
Melanocyte proliferation gene 1 (MYG1) has been implicated in cellular metabolic regulation; however, its role in cardiomyocyte metabolic reprogramming during acute myocardial infarction (AMI) remains unclear. In this study, a rat AMI model was established, …