Polyphenol found in red wine with sirtuin-activating properties
Parkinson's disease (PD), a progressive neuropathy marked by abnormal α-synuclein (α-Syn) deposition and oxidative stress-driven degeneration of dopaminergic neurons (DA neurons), remains inadequately addressed by current palliative strategies that primarily provide symptomatic relief, emphasizing the …
BACKGROUND: Cancer is a significant global health challenge, affecting millions of people every year. Overall survival rates have improved over time, but some patients exhibit treatment resistance, prompting ongoing research to find suitable and effective …
Mesenchymal stem cell (MSC)-derived exosomes are emerging as cell-free bioregenerative platforms in aesthetic dermatology. Umbilical cord (UC-MSC) and adipose-derived (AD-MSC) exosomes are among the most studied sources, yet existing data derive from heterogeneous models that …
Ovarian aging is characterized by progressive follicular reserve depletion, mitochondrial dysfunction, oxidative stress, and endocrine decline. This review examines the molecular mechanisms driving ovarian aging and evaluates emerging therapeutic strategies to preserve reproductive longevity. Key …
This review argues that combining topical skin treatments (retinoids, peptides, antioxidants) with internal supplements (NAD+ precursors, collagen peptides, polyphenols) can target multiple aging mechanisms simultaneously. While conceptually sound, the paper is a narrative review without …
Researchers tested seven compounds known to slow aging in hermaphrodite worms on male worms and found that all extended lifespan, but only sulforaphane and metformin improved reproductive function in older males. This suggests that living …
Researchers found that 3,5-dicaffeoylquinic acid (3,5-diCQA), a compound from plants, delayed aging and improved stress resistance in worms and human cells by activating a well-known cellular defense pathway called SKN-1/Nrf2. The compound appears to work …
Researchers found that corylin, a flavonoid from a traditional medicinal plant, extended lifespan and improved stress resistance in C. elegans worms by activating two key proteins that enhance cellular housekeeping and mitochondrial health. While promising, …
This discussion summarizes a podcast episode on NAD+ and its precursors (NR and NMN), claiming NR is superior to NMN for boosting cellular NAD levels and that the main benefit for healthy people is exercise …
A secondary analysis of a small diet intervention trial found that consuming polyphenol-rich foods (green tea, turmeric, berries, etc.) was associated with reduced epigenetic age—a molecular measure of biological aging. However, this was a pilot …
Dysregulation of the phosphoinositide 3-kinase/protein kinase B/mammalian target of the rapamycin (PI3K/Akt/mTOR) pathway and its complex interplay with autophagy is a crucial mechanism driving proliferation, survival, and therapeutic resistance in cancer. Natural products offer a …
Researchers tested whether squalene and saponin—two natural compounds—could reduce aging-related damage in rat brains exposed to a chemical that mimics aging. The combination treatment reduced oxidative stress markers and boosted protective proteins, but this is …