Spermidine — OutliveHub

Preliminary Cellular — Research on cellular-level aging mechanisms Animal Model bioRxiv

How Your Body's Own Molecules Fight Aging by Neutralizing Toxic Metabolites

Your body may naturally fight a hidden form of damage that causes aging using molecules you eat. This could explain why taurine and spermidine help people live longer.

Researchers discovered that common molecules in your body—taurine, spermidine, and ethanolamine—directly neutralize harmful reactive metabolites that damage proteins and drive aging. In fruit flies and mice, this 'carbon stress' defense system extended lifespan and reduced …

biorxiv (preprint)

25 Early

Preliminary Cellular — Research on cellular-level aging mechanisms Review / Commentary PubMed

How Spermidine and Exercise Work Together to Keep Muscles Young

Exercise and a natural compound called spermidine may work together to keep muscles young by triggering the cell's cleanup system.

This review examines how polyamines (especially spermidine) regulate autophagy—the cell's cleanup system—in skeletal muscle, and how exercise amplifies this process to combat age-related muscle loss. The authors propose that spermine oxidase, an enzyme that produces …

Mechanisms of ageing and development

38 Early

Preliminary Clinical Translation — Clinical trials, drug repurposing, regulatory pathways, and geroprotectors in humans Other PubMed

Epigenetic reprogramming of T cell metabolism restores function and enhances anti-tumor immunity in lung cancer.

T cell exhaustion represents a critical target for immunotherapy in cancer. Nevertheless, T cells exhibit diminished responsiveness to immune checkpoint inhibitors once they transition to a terminally exhausted state. Here we used an epigenetic drug …

Nature immunology

46 Early

Promising Lifestyle — Diet, exercise, and behavioral interventions Review / Commentary Reddit

Spermidine emerges as top longevity nutrient in 15-year study of 146 compounds

A 15-year study tracking 146 nutrients in 829 people found spermidine showed the strongest inverse association with mortality risk—equivalent to ~5.

A 15-year study tracking 146 nutrients in 829 people found spermidine showed the strongest inverse association with mortality risk—equivalent to ~5.7 years of age reduction. The post acknowledges important uncertainty: spermidine may simply be a …

r/Biohackers Feb 15, 2026

53 Promising

Preliminary Pharmacological — Drugs and compounds that may slow or reverse aging. Rapamycin, metformin, NAD+ … Review / Commentary PubMed

How polyamines control aging: New insights into a cellular anti-aging mechanism

This review synthesizes evidence that polyamines—small molecules that naturally decline with age—regulate multiple aging pathways including oxidative stress, gene expression, and protein synthesis. While animal studies show spermidine supplementation extends lifespan, human evidence remains limited, …

Amino acids Feb 12, 2026

36 Early