How We Score
How we vet the research — transparency first
How a protein that ages cells might be reversed to restore youthful growth
This lab study suggests one type of cellular aging caused by loss of a specific protein might be reversible—a promising idea, but far too early to be relevant to human …
Computer Model Suggests Combining Four Drugs May Slow Aging Better Than Using Them Alone
This is an interesting theoretical framework showing that aging might require different drug combinations than treating diabetes alone, but it's a computer prediction only—not evidence from actual patients. We'll need …
Better Way to Measure Cellular Aging Markers in the Lab
This is a clever technical improvement to the standard senescence test that could make aging research more reliable—but it's still waiting for peer review and independent confirmation before labs should …
A genetic tweak that quiets inflammation in aging cells
This is early-stage laboratory work showing a genetic mutation can reduce inflammation from aging cells in a dish. It's conceptually promising but far too preliminary to predict any human benefit—much …
Making Epigenetic Age Clocks Work with DNA Sequencing Data
This preprint describes a useful technical solution for adapting aging clocks to work with modern DNA sequencing, but it's too early to rely on these findings. Wait for peer review …
Eye fluid reveals mitochondrial damage in vision loss; alpha-ketoglutarate supplement shows promise
This early-stage, unreviewed study shows an innovative way to measure mitochondrial health in living human eyes and provides preliminary evidence that alpha-ketoglutarate supplementation can reach the eye and shift its …
NAD Precursors: What Science Says About NR vs NMN Supplements
NAD+ is genuinely important for cellular health, but the claim that NR supplements are superior to NMN or provide major exercise benefits in healthy people goes beyond current evidence. Rely …
Mike Lustgarten's Self-Experiment: NAD+ and Homocysteine Supplementation
This is a well-documented personal experiment showing one person's biomarker changes from supplementation, characterized by admirable honesty about disappointing results—but it provides no evidence that this supplement protocol actually slows …
Genetics May Account for 50% of Lifespan, New Study Suggests
While the genetic contribution to lifespan is a legitimate research question, this post cites an unverifiable study without sufficient detail to evaluate its claims. Readers should be cautious about the …
How SARS-CoV-2 Shuts Down Host Cells' Protein-Making Machinery
This study reveals a clever trick SARS-CoV-2 uses to quiet host cells while amplifying its own protein production, targeting a pathway implicated in aging. However, it's a preliminary report in …
How Your Brain Uses Predictions to Shape What You See
This is a theoretical neuroscience paper with no direct bearing on aging or longevity. While the computational model is interesting for understanding how brains use predictions, the lack of peer …