How We Score

Does Ginseng Slow Aging? A Small Study on Telomeres and Cellular Energy in Middle-Aged Adults

Ginseng showed associations with longer telomeres and better aging markers in this small uncontrolled study, but without a placebo group or independent replication, these findings are preliminary and could reflect …

How Mild Calorie Restriction Rewires Brown Fat to Stay Energetic

Mild calorie restriction rewires brown fat to work more efficiently—not by burning out, but by adapting its metabolism while preserving its heat-generating power. This is a mechanistic clue about why …

How aging immune cells drive aging throughout the body

This is an authoritative but not definitive review explaining why your immune system's aging is a central driver of whole-body aging—and why fixing it could be unexpectedly powerful for extending …

Can crocin-enriched tomatoes slow aging and protect the brain?

This fruit fly study suggests crocin-enriched tomatoes may protect aging brains by supporting mitochondria, but much more work—especially human studies—is needed before we can say whether eating these tomatoes will …

Leonurine Attenuates Ischemia-Reperfusion Injury Through PI3K/AKT/mTOR Pathway in Mouse Liver.

Predictors of Readiness to Engage in Advance Care Planning Among Older Adults With Serious Illness: Baseline Findings From the EQUAL ACP Study.

Revision Neck Lift Surgery: A Systematic Review of Indications, Techniques, and Outcomes.

Sleep Disorders and Male Infertility: Integrated Mechanisms and Precision Therapeutic Strategies.

Multiomics Analysis: Maternal Valine Intake during Protein Restriction Improves Fetal Intestinal Health in Pigs via IgA Homing.

Agaricus bisporus polysaccharide ABP alleviates X-ray-induced spermatogonial injury via the PI3K/AKT/mTOR pathway: toward a novel dietary radioprotectant.

Orthodontic treatment positively influences behavior and perception on age recognition.

Inflammatory milieu and role of epigenetic modifications in high-grade serous ovarian cancer.

Natural Products Targeting the PI3K/Akt/mTOR-Mediated Autophagy Pathway in Cancer Therapy: Recent Advances and Clinical Perspectives.

Longevity and Innovation: Cardiac Resynchronization Therapy in a 100-Year-Old Patient With Severe Heart Failure-A 4-Year Follow-Up.

How to Reverse Age-Related Immune System Decline

This is a well-informed roadmap of how to potentially reverse immune aging by restoring the thymus gland, but it's mostly a survey of promising ideas rather than proof of what …

A Protein That Blocks Exercise Benefits: Why Some People Don't Respond to Training

This preprint identifies an intriguing protein that may explain why some people gain fitness from exercise while others don't—a finding with potential longevity implications. However, it's early-stage research that needs …

New Drug Candidate 28i Shows Promise for Slowing Aging in Animal Models

This is promising preclinical drug discovery work showing a new compound can slow aging in worms and mice without the side effects of its parent drug. However, it remains early-stage …

How Aging Drives Alzheimer's Disease: A Molecular Roadmap

This paper presents a compelling framework showing how aging itself drives Alzheimer's disease through multiple interconnected pathways, suggesting that slowing aging might prevent AD. However, this is a synthesis of …

Reversing liver scarring with reprogramming mRNA in mice

This is promising early-stage lab research showing that specially designed mRNA can coax scarred liver cells back toward a youthful, healing state in mice—a novel proof-of-concept. However, it's far too …

A metabolomic clock predicts aging and disease risk across two populations

This preprint presents a promising new 'metabolomic aging clock' that tracks how fast people's bodies are aging at a molecular level and links it to mortality and disease—but because it …