How We Score

Life-course influence of birthweight and subsequent pathways on healthy aging: a Mendelian randomization study.

A Dual Approach to Glioblastoma Treatment with Epigenetic Reprogramming and Neurogenetic Modulation.

Effects of Profhilo® Tissue Bioremodeling on Skin Texture and Perioral Wrinkles: A Randomized Controlled Triple-Blind Clinical Trial.

Poly(γ-glutamic acid)-thickened PLLA microspheres with enhanced biocompatibility and efficacy in aged mice.

Single-cell-scale spatial transcriptome reveals early regional priming of the developing mouse ovary

Phthalate Esters in Aquatic Ecosystems: A Multiscale Threat from Molecular Disruption to Ecological Risks.

TREM2+ macrophages accumulate in alveoli of human pulmonary tuberculosis providing a permissive niche for bacterial growth

Natural Antimicrobial Activity of Nettle (Urtica dioica L.) Leaf Extract for Shelf-Life Extension of Mashed Potatoes.

Nora virus proliferates in dividing intestinal stem cells and thereby sensitizes Drosophila flies to Pseudomonas aeruginosa intestinal infection and to oxidative stress

Urban Care Farming to Enhance Quality of Life Among Older Adults: Protocol for a Waitlist Randomized Trial.

Acute rapamycin treatment reveals novel mechanisms of behavioral, physiological, and functional dysfunction in a maternal inflammation mouse model of autism and sensory over-responsivity

Radiotherapy-Induced Skin Fibrosis: Pathophysiology, Emerging Therapeutics, and the Role of Dermatology.

Aging and longevity in decades-old genebanked seeds from U.S. endangered plant species: Assessments using survival and RNA integrity assays.

A data-driven dietary pattern anchored to slower epigenetic aging is associated with a spectrum of aging-related health outcomes

Comparative Cardiovascular Effectiveness of Glucagon-Like Peptide 1 Receptor Agonists and Sodium-Glucose Cotransporter-2 Inhibitors in Diabetes Mellitus

A Dialectical Behavior Therapy Skills Training Intervention for Cigarette Smoking by Patients with Cancer: Focused Qualitative Inquiry Prior to Feasibility Trial

Can We Restore Aging Immune Systems to Make Cancer Drugs Work Better?

This is a thoughtful overview of promising but unproven strategies to restore immune function in older cancer patients, not a definitive study showing they work. The real test will come …

A protein that clears harmful RNA buildup could be key to aging

A newly discovered enzyme prevents aging-related RNA damage in animals, suggesting a promising target for longevity therapies—but this finding is too recent to confirm and needs independent replication before clinical …

How Caloric Restriction Reshapes Your Metabolism Over 2 Years

This well-designed study provides the first detailed snapshot of metabolic changes during long-term caloric restriction in humans, showing that carbohydrate and fat metabolism shift in time-dependent ways. However, as an …

A Natural Plant Compound Slows Aging in Worms by Boosting Cellular Cleanup

Corylin shows genuine promise in a worm model by activating well-established longevity pathways, but these are early-stage findings. Don't expect human supplements or treatments from this work alone—much validation in …