How We Score
How we vet the research — transparency first
Can crocin-enriched tomatoes slow aging and protect the brain?
This fruit fly study suggests crocin-enriched tomatoes may protect aging brains by supporting mitochondria, but much more work—especially human studies—is needed before we can say whether eating these tomatoes will …
How to Reverse Age-Related Immune System Decline
This is a well-informed roadmap of how to potentially reverse immune aging by restoring the thymus gland, but it's mostly a survey of promising ideas rather than proof of what …
A Protein That Blocks Exercise Benefits: Why Some People Don't Respond to Training
This preprint identifies an intriguing protein that may explain why some people gain fitness from exercise while others don't—a finding with potential longevity implications. However, it's early-stage research that needs …
New Drug Candidate 28i Shows Promise for Slowing Aging in Animal Models
This is promising preclinical drug discovery work showing a new compound can slow aging in worms and mice without the side effects of its parent drug. However, it remains early-stage …
How Aging Drives Alzheimer's Disease: A Molecular Roadmap
This paper presents a compelling framework showing how aging itself drives Alzheimer's disease through multiple interconnected pathways, suggesting that slowing aging might prevent AD. However, this is a synthesis of …
Reversing liver scarring with reprogramming mRNA in mice
This is promising early-stage lab research showing that specially designed mRNA can coax scarred liver cells back toward a youthful, healing state in mice—a novel proof-of-concept. However, it's far too …
A metabolomic clock predicts aging and disease risk across two populations
This preprint presents a promising new 'metabolomic aging clock' that tracks how fast people's bodies are aging at a molecular level and links it to mortality and disease—but because it …
How a Damaged Protein Spreads Aging Signals Through Your Body
A damaged form of HMGB1 protein appears to spread aging signals throughout the body, and blocking it reduced aging markers and improved healing in mice—but this finding is very new …
How Partial Reprogramming Reverses Aging Marks on Key Genes
This is credible, technically sophisticated work showing that partial reprogramming reverses age-related epigenetic changes, particularly on genes controlled by PRC2. However, it's an early mechanistic finding in mice that needs …
How Japanese Lifestyle Habits Shape Biological Aging Markers
This carefully conducted study suggests lifestyle habits like smoking, exercise, and sauna use associate with epigenetic aging markers in Japanese adults—but it's early-stage evidence that hasn't been peer-reviewed yet. Don't …