How We Score
How we vet the research — transparency first
Preliminary
Natural compound DMB reduces cellular aging by activating DNA repair protein FEN1
This is a solid proof-of-concept study showing a natural compound can reduce cellular aging markers in the lab and extend lifespan in worms—promising enough to justify further study, but too …
36
/100
First-report study with zero citations (recent publication, but no independent replication yet). Single human cell line tested, no primary cells …
Preliminary
How chemical marks on RNA control telomeres and aging
This thoughtful review proposes that chemical tags on RNA—not just DNA mutations—are key regulators of telomere aging, and highlights promising research directions. However, it presents no new experimental proof; the …
28
/100
This is a review article with no primary data, so no sample size, no experiments, and no replication data exist. …
Preliminary
How bats' virus defenses may hold secrets to extreme longevity
This early-stage work suggests that bats' extreme longevity may stem from evolved adaptations that let them tolerate viruses peacefully—and these same genes protect against cancer. It's an intriguing hypothesis that …
29
/100
Preprint status (not peer-reviewed). Small sample size (8 species, ~50 individuals estimated). Functional validation limited to in vitro cell cultures—no …
38
/100
Preliminary
On period, cohort and population life expectancy
34
/100
43
/100
Preliminary
Epigenetic regulation of cellular senescence.
38
/100