How We Score
How we vet the research — transparency first
Can crocin-enriched tomatoes slow aging and protect the brain?
This fruit fly study suggests crocin-enriched tomatoes may protect aging brains by supporting mitochondria, but much more work—especially human studies—is needed before we can say whether eating these tomatoes will …
How healthy diets add years to your life—even if your genes say otherwise
Multiple healthy dietary patterns—Mediterranean, plant-based, DASH, and others—consistently added 1.5–3 years of life expectancy in a large study, and these benefits occurred regardless of whether people carried genetic variants linked …
How to Reverse Age-Related Immune System Decline
This is a well-informed roadmap of how to potentially reverse immune aging by restoring the thymus gland, but it's mostly a survey of promising ideas rather than proof of what …
A Protein That Blocks Exercise Benefits: Why Some People Don't Respond to Training
This preprint identifies an intriguing protein that may explain why some people gain fitness from exercise while others don't—a finding with potential longevity implications. However, it's early-stage research that needs …
New Drug Candidate 28i Shows Promise for Slowing Aging in Animal Models
This is promising preclinical drug discovery work showing a new compound can slow aging in worms and mice without the side effects of its parent drug. However, it remains early-stage …
How Aging Drives Alzheimer's Disease: A Molecular Roadmap
This paper presents a compelling framework showing how aging itself drives Alzheimer's disease through multiple interconnected pathways, suggesting that slowing aging might prevent AD. However, this is a synthesis of …
Reversing liver scarring with reprogramming mRNA in mice
This is promising early-stage lab research showing that specially designed mRNA can coax scarred liver cells back toward a youthful, healing state in mice—a novel proof-of-concept. However, it's far too …
Nine Core Mechanisms Explain Why We Age
This paper is a 'greatest hits' summary that organized everything we knew about aging into nine common patterns. It didn't discover new biology, but it gave researchers a shared roadmap—think …
A metabolomic clock predicts aging and disease risk across two populations
This preprint presents a promising new 'metabolomic aging clock' that tracks how fast people's bodies are aging at a molecular level and links it to mortality and disease—but because it …
How a Damaged Protein Spreads Aging Signals Through Your Body
A damaged form of HMGB1 protein appears to spread aging signals throughout the body, and blocking it reduced aging markers and improved healing in mice—but this finding is very new …