How We Score
How we vet the research — transparency first
Healthy Lifestyle Habits Add Years of Good Health in Older Adults
In healthy older adults, sticking to four proven lifestyle habits—good diet, exercise, no smoking, and moderate alcohol—statistically adds about 10 months of healthy living per person over 6 years and …
Healthy Habits Matter More Than Genes for Living Past 80
Even if you're 80+ or don't have 'longevity genes,' healthy habits like exercise, good sleep, and not smoking cut your death risk by about 40%—far more than genes alone. It's …
Why Some Families Stay Healthy Into Old Age: The Role of 'Good' Genes
This study shows that people in families with a history of living long and healthy tend to inherit fewer genetic risk factors for heart disease. It's not that they have …
How Yeast Reveals the Hidden Network of Aging Genes
This paper provides a useful map of how genes control aging in yeast and a method that could apply to humans, but it's early-stage work that needs validation in mammalian …
Can changing what you eat reverse your biological age in just 4 weeks?
Your diet can measurably improve health markers within weeks, but this study can't tell us whether these changes actually slow aging itself. Longer-term studies tracking disease outcomes are needed before …
Why centenarians' immune systems stay young
This review reveals that people who live to 100+ have found ways to keep their immune systems young, suggesting that extreme longevity is biologically possible. However, the findings are mostly …
How to Study People Living Past 110: A Blueprint for Global Research
This is a planning document, not a discovery. It doesn't tell us new secrets about living to 110, but it proposes a better way for scientists worldwide to coordinate their …
Mapping the genetic and molecular roots of aging and longevity
This is a smart detective work that uses big genetic databases to spot promising leads for aging research—genes and molecules worth studying further. However, spotting a link in data is …
A New Clock Reveals How Our Immune System Ages—and How to Slow It
This paper identifies a promising molecular target (RUNX1) for reversing immune aging in mice and cell cultures, with potential implications for human therapies. However, it's early-stage work requiring replication and …
Facial Laser Safety: A Review of Complications and What Goes Wrong
This clinical safety review shows that facial laser complications are common and affect darker-skinned patients more often, highlighting the need for better safety guidelines—but it is not a longevity study …
How calorie restriction reduces aging inflammation through immune pathway control
Calorie restriction works partly by quieting an overactive immune protein that makes you age faster. Blocking this protein in mice reduced aging-related inflammation, suggesting it could be a new drug …
What Slows (and Speeds) Skin Aging at the DNA Level
This study identifies 37 factors—from lifestyle choices to medications—correlated with slower or faster skin aging at the molecular level. The findings are a good starting point for testing whether any …
Genetic secrets of extreme old age discovered in Taiwan
This is solid population genetics work showing that some genes protect extreme longevity in Taiwanese people, but the practical impact is small—your lifestyle and heart health are still the main …
Popular Senolytic Drugs Failed to Work in Rigorous Independent Testing
Drugs previously hyped as senolytic 'anti-aging' treatments didn't actually work when tested independently. This shows why we need rigorous confirmation before believing any longevity breakthrough.
Why lowering IGF-1 doesn't always extend lifespan—it depends on your mitochondria
This mouse study reveals that one of the most promising anti-aging strategies (lowering IGF-1) only works if your mitochondria are healthy—it's a reminder that aging is complicated and we may …
Can a longevity protein protect Parkinson's patients from memory loss?
A longevity protein shows promise in helping Parkinson's patients preserve cognitive function through mouse and genetic studies, but these findings need to be confirmed in human clinical trials before we …
Which biological aging markers best predict health decline? A 7-year study of 1,083 older adults
This well-conducted study compared 16 aging biomarkers and identified two (Allostatic Load and DunedinPACE) as the most reliable predictors of health decline in older age, but the findings are recent …
What makes centenarians tick? A metabolic fingerprint of extreme longevity
This is solid observational research identifying intriguing metabolic differences in centenarians that merit follow-up investigation. However, because it's not yet replicated and cannot prove cause-and-effect, treat the findings as promising …
Dogs as aging models: A new study validates canine biomarkers of aging
This is a promising early-stage study that could eventually validate dogs as a faster, more practical aging research model—but the critical results on predicting health outcomes are still being analyzed …