How We Score
How we vet the research — transparency first
A New Blood Test that Predicts Aging and Disease Risk Across Millions of People
This is rigorous work that validates a promising new way to measure biological age using standard blood tests across a large, diverse population. However, it's too early to use this …
Your retinal images may reveal hidden aging and heart-kidney-metabolic disease risk
This is a well-executed observational study showing that an AI-analyzed eye photograph correlates with cardiovascular and metabolic disease risk, but it's not yet proof that this screening tool will help …
Gene activity patterns reveal how some people stay healthy longer
This paper identifies gene-expression patterns associated with healthy aging in long-lived families and develops a clock that predicts mortality risk. It's promising foundational work, but we need independent replication and …
Exercise's Brain-Boosting Molecule Reverses Memory Loss by Cleaning Up Blood Vessels
This is a rigorous mechanistic study identifying a promising vascular target (TNAP) that could allow us to chemically mimic exercise's memory-boosting effects. However, it's currently mice-only science; human safety and …
How pregnancy ages some body systems while rejuvenating others—insights for slowing aging
Pregnancy provides a natural 'stress test' showing that some body systems can rejuvenate while others age—findings that challenge our assumptions about irreversible aging and could inspire new research directions, though …
Vigorous Exercise 50-150x More Powerful Than Light Activity for Longevity
A Nature-published study provides good evidence that vigorous exercise delivers greater health benefits per minute than lighter activity, but this Reddit summary overstates certainty by presenting dramatic risk reduction ratios …
Spermidine emerges as top longevity nutrient in 15-year study of 146 compounds
Spermidine in foods like beans and mushrooms shows a strong association with living longer, but this could mean either spermidine itself is beneficial or it's simply a marker of eating …
Reversing Blood Cell Aging by Fixing Lysosomal Dysfunction
Scientists found that aging damages lysosomes—cellular garbage disposals—in blood-forming stem cells, and blocking the enzyme that causes this damage restored youthful function in mouse cells. This is a promising mechanistic …
Dr. Conboy on Epigenetic Clocks: Misalignment, Noise, and What They Actually Measure
Dr. Conboy presents credible scientific criticism of epigenetic aging clocks, arguing they measure statistical patterns rather than true biological age and miss key aging hallmarks—viewers should understand this as expert …
NMN & NAD Supplements: Debunking the Anti-Aging Hype with Science
While early animal research made NAD-boosting supplements seem promising, rigorous follow-up studies show they don't extend lifespan in mice or improve symptoms in humans, even when they successfully raise NAD …
Castration & Lifespan: What the Science Actually Shows About Testosterone
While castration does extend lifespan in animals and historical eunuchs, the real lesson isn't 'lower your testosterone'—it's that excessive growth signaling may drive aging, and that healthy testosterone levels remain …
Exercise, Heat, and Cold: Dr. Patrick's Healthspan Optimization Guide
This is a well-credentialed scientist presenting solid evidence that vigorous exercise is one of the most powerful life-extending interventions available; the core claims align with peer-reviewed science, though some study …
Seed Oils vs. Lard: What the Science Actually Shows
Both seed oils and lard are bad when used for frying because fried foods are calorie-dense junk; the choice between them matters far less than avoiding regular consumption. Don't fall …
r/longevity Introductory Guide: Resources for Aging Biology Research
This is a well-curated introductory resource for understanding legitimate aging biology research, appropriately warning against quackery while directing readers to peer-reviewed papers and academic institutions. It's an excellent starting point …
Women's Hormones and Alzheimer's Risk: New Understanding of Brain Health in Menopause
This is a credible, well-informed conversation about detecting Alzheimer's disease before symptoms appear—an important topic for brain health. However, viewers should note that specific studies and evidence aren't cited in …