How We Score
How we vet the research — transparency first
Young Blood Plasma Exchange Shows Promise as Safe Treatment for Early Alzheimer's
This study shows that replacing older adults' blood plasma with young donor plasma is safe and can be done in humans—an important first step. But it's far too early to …
How naked mole rats rewired their proteins to live exceptionally long
This study reveals a fascinating clue—naked mole rats have evolved unusual protein structures linked to stress resistance—but it's a preliminary computational analysis that needs experimental follow-up to confirm the story …
A Peanut Compound Reverses Blood Stem Cell Aging in Mice
Researchers found a natural compound from peanuts that restored function to aging blood stem cells in mice—an encouraging lead that requires years of additional testing before potential human use. Don't …
Why Some Families Stay Healthy Into Old Age: The Role of 'Good' Genes
This study shows that people in families with a history of living long and healthy tend to inherit fewer genetic risk factors for heart disease. It's not that they have …
AI Reads Your Heart's Age to Predict Heart Disease Risk
This AI tool shows promise for identifying heart disease risk before symptoms appear, but it's preliminary research that needs peer review and validation before doctors would use it clinically. The …
A Safer Rapamycin-Like Drug Extends Lifespan in Worms
This is early-stage research showing a modified rapamycin might work better than the original drug in simple worms. It's promising but requires years of testing in mammals before anyone should …
Small RNA molecules show promise as aging clocks in blood tests
This editorial makes a reasonable case that scientists should look for better aging biomarkers in blood, but it's a 'think piece' summarizing existing ideas, not proof that these markers work …
How Yeast Reveals the Hidden Network of Aging Genes
This paper provides a useful map of how genes control aging in yeast and a method that could apply to humans, but it's early-stage work that needs validation in mammalian …
How Replacing Damaged Cells and Tissues Could Reverse Aging
This is a roadmap from top aging researchers proposing we move beyond slowing aging to actively repairing and replacing damaged cells and tissues. It's a promising vision backed by real …
How Fasting Triggers a Hidden Hormone to Keep Us Healthy as We Age
This study identifies a hormone pathway that explains how fasting improves health during aging in worms—a finding that could eventually inform human therapies, but needs confirmation in mammals before drawing …
Blood pressure drug losartan rejuvenates aging metabolism in mice and older adults
Losartan, an old blood-pressure drug, shows promise for reversing aging at the molecular level in both animals and early human tests, but we need larger, longer studies measuring real-world health …
Can changing what you eat reverse your biological age in just 4 weeks?
Your diet can measurably improve health markers within weeks, but this study can't tell us whether these changes actually slow aging itself. Longer-term studies tracking disease outcomes are needed before …
How a protein tweak keeps blood-forming stem cells young and extends mouse lifespan
This mouse study shows that tweaking a protein to keep blood-stem cells young also extends lifespan, suggesting stem cell health may be crucial for aging. However, the effect is modest, …
A New NAD+ Supplement Boosts Cells' Energy Without Raising Blood Levels
This early-stage study shows a clever new way to get NAD+ inside cells efficiently, but it's far too preliminary to claim any anti-aging benefit. We're seeing a biomarker shift in …
How Your Body's Own Molecules Fight Aging by Neutralizing Toxic Metabolites
This is promising early-stage research suggesting your body has a natural defense against a form of metabolic damage that drives aging, and common dietary supplements may activate it. However, it's …
How DNA Chaos in Yeast Chromosomes Drives Aging and Life Span Differences
Researchers found a plausible molecular explanation for why genetically identical cells age at different rates, but the work is very early-stage and needs independent peer review and validation before drawing …
Poor neighborhoods linked to faster biological aging in DNA
Living in disadvantaged neighborhoods appears linked to faster biological aging at the DNA level, but this preprint needs peer review and larger studies before we can be confident in the …
How Reduced Phosphatidylcholine Affects Aging and Lifespan in Worms
This early-stage study suggests that how cells build their outer membranes may affect aging, but the findings in worms need to be tested in larger animals and humans before we …
Aging May Be a Spreading Disorder of System-Wide Coordination
This is an intriguing new way to measure aging by tracking how well your body's systems stay coordinated—early results look promising, but the idea is so new it needs independent …
How exercise activates SIRT1, a key aging-control protein
Exercise appears to activate SIRT1, a protein that helps prevent multiple aging processes. This explains some of why exercise extends lifespan, though the research is still young and human studies …