How We Score
How we vet the research — transparency first
Can We Restore Aging Immune Systems to Make Cancer Drugs Work Better?
This is a thoughtful overview of promising but unproven strategies to restore immune function in older cancer patients, not a definitive study showing they work. The real test will come …
A protein that clears harmful RNA buildup could be key to aging
A newly discovered enzyme prevents aging-related RNA damage in animals, suggesting a promising target for longevity therapies—but this finding is too recent to confirm and needs independent replication before clinical …
A New Blood Test that Predicts Aging and Disease Risk Across Millions of People
This is rigorous work that validates a promising new way to measure biological age using standard blood tests across a large, diverse population. However, it's too early to use this …
How Caloric Restriction Reshapes Your Metabolism Over 2 Years
This well-designed study provides the first detailed snapshot of metabolic changes during long-term caloric restriction in humans, showing that carbohydrate and fat metabolism shift in time-dependent ways. However, as an …
Your retinal images may reveal hidden aging and heart-kidney-metabolic disease risk
This is a well-executed observational study showing that an AI-analyzed eye photograph correlates with cardiovascular and metabolic disease risk, but it's not yet proof that this screening tool will help …
A Natural Plant Compound Slows Aging in Worms by Boosting Cellular Cleanup
Corylin shows genuine promise in a worm model by activating well-established longevity pathways, but these are early-stage findings. Don't expect human supplements or treatments from this work alone—much validation in …
Two-phase aging model reveals critical vulnerability period in flies and mice
This preprint offers an intriguing mathematical framework showing aging may involve a dangerous transition point—but it's early-stage work awaiting peer review and replication. If confirmed, it could refocus aging research …
Plant extract Salvia plebeia triggers cellular cleanup and reverses aging signs in mice
A plant extract activates cellular cleanup (autophagy) and reverses aging markers in mice, with a compound called rosmarinic acid identified as the likely active ingredient—an interesting lead, but human studies …
Gene activity patterns reveal how some people stay healthy longer
This paper identifies gene-expression patterns associated with healthy aging in long-lived families and develops a clock that predicts mortality risk. It's promising foundational work, but we need independent replication and …
Can bezisterim slow brain aging in Alzheimer's disease?
An experimental anti-inflammatory drug appears to reverse epigenetic markers of aging in Alzheimer's patients, raising hope for a new longevity-focused therapeutic approach. But this early-stage preprint lacks peer review, has …
Can Young Blood Make You Younger? What Science Actually Shows (and Doesn't)
Young plasma shows real promise in animals, but human clinical evidence is weak and preliminary. The authors warn against treating this as a proven therapy now—rigorous clinical trials are essential …
How caloric restriction keeps blood-forming stem cells young in mice
This mouse study identifies two key genes (KDR and PU.1) that control how caloric restriction rejuvenates blood stem cells, pointing toward potential drug targets. However, human translation remains uncertain, and …
How a NAD+ mimic activates the aging-linked SIR2 protein through internal communication networks
This computational study maps an intriguing mechanism by which NAD+-mimics could activate SIR2, and identifies a potential drug target—but it's a hypothesis-generating paper, not proof of concept. Experimental validation and …
A Fungal Compound Protects Worm Brains from Amyloid Damage by Boosting Cellular Cleanup
This study shows a fungal compound protects worms from amyloid toxicity through well-known cellular repair mechanisms, which is scientifically interesting. However, it's very early-stage work—many steps and years of research …
How DNA methylation reveals aging in a fish with no genetic variation
This clever study shows that aging leaves a clear chemical signature in DNA methylation—one that emerges independently of genetic variation. While the findings are promising and methodologically sound, they're preliminary …
How Young Blood Rejuvenates Aging Brain Blood Vessels: The IGF-1 Connection
This research identifies a growth factor called IGF-1 as a key player in how young blood rejuvenates aging brains, but suggests it's only part of the story. While promising for …
Why Low-Cholesterol Diets Shorten Lifespan in Female Fruit Flies: A Gut Health Story
In fruit flies, strict low-cholesterol diets backfired—shortening rather than extending life, often by damaging the gut barrier. This doesn't mean cholesterol is healthy in humans, but it suggests that extreme …
Exercise's Brain-Boosting Molecule Reverses Memory Loss by Cleaning Up Blood Vessels
This is a rigorous mechanistic study identifying a promising vascular target (TNAP) that could allow us to chemically mimic exercise's memory-boosting effects. However, it's currently mice-only science; human safety and …
Testing a Personalized Digital Health Protocol to Boost Resilience in One Individual
This is an interesting proof-of-concept for using AI and continuous monitoring to track health biomarkers, but it is not evidence that any particular intervention extends human healthspan. It's a self-study …