How We Score
How we vet the research — transparency first
Broken mitochondria in blood vessel cells trigger a healthy metabolic response in mice
This mouse study reveals that damaging mitochondria in blood vessel linings paradoxically improves metabolism and slows aging through a stress-response mechanism. While scientifically elegant, it's early-stage work that needs independent …
A Plant Compound Delays Aging in Cells by Activating Stress-Defense Pathways
This paper shows a plant compound activates protective cellular pathways in worms and cultured cells, which is interesting mechanistically but a very early stage of research—far from proof that the …
A Blood Test for Midlife Health Can Predict Disease and Improve With Lifestyle Changes
This promising blood test could help middle-aged people understand their disease risk and motivate healthier living, but it's too early to act on. Wait for peer review and replication before …
How metformin extends yeast lifespan through chromatin control and retrotransposon activity
Metformin likely extends yeast lifespan through chromatin changes that activate retrotransposons—previously unknown mechanism worth investigating in mammals. However, this is early-stage yeast research; human relevance remains speculative and requires independent …
Can boosting NAD+ reverse ovarian aging? What we know and don't know yet
NAD+ is plausibly important for ovarian health based on cellular biology, but we're still in the early phase of understanding how it actually works in human ovaries and whether boosting …
Silencing a protein called CG42795 boosts autophagy and extends lifespan in fruit flies
This is early-stage research showing a promising new target (CG42795/TBC1D30) for enhancing cellular autophagy and extending lifespan in model organisms. It's worth following, but it's far too preliminary to guide …
A comprehensive map of how skeletal muscle ages at the genetic level
This is an ambitious genomic atlas that could become a valuable reference for muscle aging research, but it's still a preprint describing correlations and network patterns rather than proven interventions …
How Your Body's Internal Clock Ages and Why It Matters for Living Longer
This is a roadmap essay showing how circadian biology (your body's internal clock) could be a master key to understanding and slowing aging. While promising conceptually, the real evidence will …
Plant protein extracts from fava beans and peas extend healthy lifespan in worms via different pathways
Fava beans and peas contain protein fragments that extend healthy aging in lab worms through different cellular repair pathways—an encouraging sign, but much more research (especially in mammals and humans) …
How Heart Radiation Therapy Rewires Heart Cell Gene Expression for Better Rhythm Control
This mechanistic study elegantly explains how heart radiation therapy produces lasting benefits through epigenetic changes that boost electrical conduction genes. It's credible and well-executed research, but it's an early finding …
How balanced proteasome regulation keeps cells healthy and extends lifespan
This elegant study shows that longevity pathways only work when your cells' protein-recycling machinery is properly balanced—a finding that could reshape how we design aging interventions, but needs replication in …
Genetic Markers of Healthy Aging: What Separates Long Life from Good Health in Old Age
This study identifies candidate genes linked to healthy aging in people over 90, but it's a genetic map, not a mechanism. The findings suggest aging is more complex than single-gene …
Why fasting works differently for different people: A genetic explanation
Genetics strongly influences how much intermittent fasting helps you live longer—a key insight that means people should expect different outcomes from the same fasting protocol. Before fasting is widely recommended, …
The Sleep Sweet Spot: How 6–8 hours connects to biological aging across your whole body
This preprint suggests a sweet spot of 6–8 hours of sleep for minimizing biological aging markers, but the findings are preliminary and require peer review and replication before influencing medical …
Some Anti-Aging Compounds Extend Male Worm Lifespan, But Not Always Reproductive Health
This worm study suggests that compounds extending lifespan don't automatically preserve all aspects of health—a useful reality check for anti-aging research. However, it's early-stage work in a simplified organism that …