How We Score
How we vet the research — transparency first
How pregnancy ages some body systems while rejuvenating others—insights for slowing aging
Pregnancy provides a natural 'stress test' showing that some body systems can rejuvenate while others age—findings that challenge our assumptions about irreversible aging and could inspire new research directions, though …
Gut Bacteria Linked to Living Past 90: What Their Microbiomes Reveal
Centenarians have distinctly different and more beneficial gut bacteria than typical older adults, pointing to microbiota composition as a possible lever for healthy aging. However, this is an early correlational …
Urolithin A and cardiovascular health: preclinical promise meets human biomarker data
Urolithin A is a promising compound with solid preclinical evidence and early human data showing cardiovascular biomarker improvements, but the evidence is still preliminary—based on surrogate markers rather than proven …
NAD Precursors: What Science Says About NR vs NMN Supplements
NAD+ is genuinely important for cellular health, but the claim that NR supplements are superior to NMN or provide major exercise benefits in healthy people goes beyond current evidence. Rely …
A brain protein that declines with age may hold clues to extending lifespan
This is early-stage but promising research identifying a brain protein that extends fruit fly lifespan. It's a solid proof-of-concept using innovative methods, but it's premature to expect human applications—many candidate …
How Exercise Clears Damaged Cells and Reverses Muscle Aging
Exercise likely does help clear damaged cells from muscle tissue and improve metabolic health, which aligns with solid longevity science, but this Reddit post is an enthusiastic summary of a …
Vigorous Exercise 50-150x More Powerful Than Light Activity for Longevity
A Nature-published study provides good evidence that vigorous exercise delivers greater health benefits per minute than lighter activity, but this Reddit summary overstates certainty by presenting dramatic risk reduction ratios …
Spermidine emerges as top longevity nutrient in 15-year study of 146 compounds
Spermidine in foods like beans and mushrooms shows a strong association with living longer, but this could mean either spermidine itself is beneficial or it's simply a marker of eating …
Reversing Blood Cell Aging by Fixing Lysosomal Dysfunction
Scientists found that aging damages lysosomes—cellular garbage disposals—in blood-forming stem cells, and blocking the enzyme that causes this damage restored youthful function in mouse cells. This is a promising mechanistic …
Can Polyphenol-Rich Foods Slow Epigenetic Aging?
Polyphenol-rich foods like green tea, turmeric, and berries showed a promising link to slower epigenetic aging in this pilot study, but the effect was modest and unproven—larger, independent trials are …
Cardiovascular Biomarkers Deep Dive: Mike Lustgarten's 2025 Blood Test #7
This is a thorough, well-documented personal health tracking effort that demonstrates how to contextualize blood test results against epidemiological evidence—valuable for self-monitoring enthusiasts, but not a substitute for medical evaluation. …
Mike Lustgarten's Self-Experiment: NAD+ and Homocysteine Supplementation
This is a well-documented personal experiment showing one person's biomarker changes from supplementation, characterized by admirable honesty about disappointing results—but it provides no evidence that this supplement protocol actually slows …
Self-Tracked Diet & Biological Age: One Man's 15-Year Younger Result
This is an impressive example of personal health tracking and self-experimentation, but one person's dietary correlations with biomarkers—especially weak correlations—are not strong evidence for what will work for you. The …
TMAO: Health Risks, Dietary Sources, and Personalized Tracking
TMAO is a real health marker worth monitoring, but the story is more nuanced than "avoid TMAO-containing foods"—your gut bacteria composition and intestinal health (driven by fiber, exercise, and aging) …
Beta-Hydroxybutyrate: The Ketone Link to Longevity in Mice
This video presents interesting mouse data linking a ketone body (BHB) to longevity through caloric restriction and ketogenic diet, with plausible mechanistic explanations—but all evidence is pre-clinical and doesn't prove …
Visceral Fat Reduction and Lifespan: Mike Lustgarten's 3-Year Self-Tracking
Rodent studies show visceral fat removal extends lifespan; Lustgarten's personal data shows he maintains unusually low visceral fat for his age, but this is one person measured three times—not proof …
Dr. Conboy on Epigenetic Clocks: Misalignment, Noise, and What They Actually Measure
Dr. Conboy presents credible scientific criticism of epigenetic aging clocks, arguing they measure statistical patterns rather than true biological age and miss key aging hallmarks—viewers should understand this as expert …
NMN & NAD Supplements: Debunking the Anti-Aging Hype with Science
While early animal research made NAD-boosting supplements seem promising, rigorous follow-up studies show they don't extend lifespan in mice or improve symptoms in humans, even when they successfully raise NAD …
Castration & Lifespan: What the Science Actually Shows About Testosterone
While castration does extend lifespan in animals and historical eunuchs, the real lesson isn't 'lower your testosterone'—it's that excessive growth signaling may drive aging, and that healthy testosterone levels remain …
Vigorous Exercise May Be 4-10x More Effective Than Moderate Activity
While this video raises a valid point—that current exercise guidelines are based on calorie burn rather than health outcomes—the lack of citation for the key study makes it impossible to …