How We Score
How we vet the research — transparency first
Rapamycin reduces age-related motor decline in mice, especially in females
Rapamycin preserved movement and motor control in aging mice, particularly in females, seemingly by reducing cellular stress in the brain. This is encouraging but still preliminary—animal findings require human testing …
Eye fluid reveals mitochondrial damage in vision loss; alpha-ketoglutarate supplement shows promise
This early-stage, unreviewed study shows an innovative way to measure mitochondrial health in living human eyes and provides preliminary evidence that alpha-ketoglutarate supplementation can reach the eye and shift its …
Reversing cell aging in stem cells using temporary genetic reprogramming
This is a promising proof-of-concept for temporarily 'resetting' aging in stem cells using non-integrating viral vectors, but it's early-stage laboratory work. Before this can help patients, researchers need to test …
Natural compound DMB reduces cellular aging by activating DNA repair protein FEN1
This is a solid proof-of-concept study showing a natural compound can reduce cellular aging markers in the lab and extend lifespan in worms—promising enough to justify further study, but too …
How chemical marks on RNA control telomeres and aging
This thoughtful review proposes that chemical tags on RNA—not just DNA mutations—are key regulators of telomere aging, and highlights promising research directions. However, it presents no new experimental proof; the …
Dogs as aging models: A new study validates canine biomarkers of aging
This is a promising early-stage study that could eventually validate dogs as a faster, more practical aging research model—but the critical results on predicting health outcomes are still being analyzed …
How bats' virus defenses may hold secrets to extreme longevity
This early-stage work suggests that bats' extreme longevity may stem from evolved adaptations that let them tolerate viruses peacefully—and these same genes protect against cancer. It's an intriguing hypothesis that …