How We Score
How we vet the research — transparency first
Which biological aging markers best predict health decline? A 7-year study of 1,083 older adults
This well-conducted study compared 16 aging biomarkers and identified two (Allostatic Load and DunedinPACE) as the most reliable predictors of health decline in older age, but the findings are recent …
What makes centenarians tick? A metabolic fingerprint of extreme longevity
This is solid observational research identifying intriguing metabolic differences in centenarians that merit follow-up investigation. However, because it's not yet replicated and cannot prove cause-and-effect, treat the findings as promising …
How mTOR inside neurons drives aging of touch-sensing cells in worms
This worm study shows that mTOR inside neurons contributes to age-related structural damage (excessive branching), but doesn't change how long worms live. It's an important clue for understanding where mTOR …
HIV Speeds Up Aging at the Protein Level, But Treatment Reverses It
This well-designed study provides the strongest evidence yet that untreated HIV genuinely accelerates biological aging at the protein level, and that antiretroviral therapy reverses it—but wait for peer-reviewed publication and …
A Bile Acid Supplement in Mom's Diet May Extend Her Offspring's Lifespan in Fruit Flies
Maternal bile acid supplementation in fruit flies produced robust lifespan extension in offspring via a specific metabolic gene—an intriguing proof-of-concept with real mechanistic insight, but it's early-stage, needs replication, and …
DunedinPACE epigenetic clock best predicts cognitive decline in older adults
This early-stage study identifies DunedinPACE as a promising DNA-based marker for cognitive aging, but the findings are preliminary and need validation by other researchers before using the test to predict …
A blood test for cellular aging predicts disease and mortality risk
This is promising early-stage research suggesting a blood test could measure cellular aging and predict serious disease—but it's not yet peer-reviewed and needs independent confirmation before relying on it clinically. …
Can senolytic drugs prevent bone loss in aging and gum disease?
Senolytic drugs show promise for age-related bone loss in mice, but don't work for bone loss driven by active infection and inflammation. This suggests that clearing senescent cells alone won't …
How immune cells called NK cells shape healthy aging
This thoughtful review explains how your immune cells called NK cells age and become less effective, contributing to age-related disease, and suggests measuring NK function could help predict immune health—but …
Growing human aging in a chip: A new lab model to test longevity drugs
This is a clever engineering feat that could accelerate testing of anti-aging drugs by compressing human aging into days instead of decades, but it's an early-stage tool that must be …
How Planarians Lose Fertility with Age—and How to Reverse It
This intriguing study shows that planarian reproductive aging stems from a drift in the body's positional 'map' rather than irreversible damage—and the process can be reversed. While promising as proof-of-concept, …
How fat tissue controls aging through a molecular switch for insulin
This is solid foundational research showing how fat tissue acts as a control center for aging via an insulin-signaling dimmer switch. It's a promising lead for understanding interorgan aging mechanisms, …
How caloric restriction preserves liver and kidney health in aging mice
This is a well-designed mouse study showing that calorie restriction slows tissue aging in the liver and kidneys through mechanisms involving SIRT1 activation and reduced cellular senescence—supportive but incremental evidence …
Can saliva measure biological aging as well as blood?
This preprint shows that saliva-based biological age tests give different results than blood tests, so they shouldn't be used interchangeably—but it's too early to draw firm conclusions since the study …
Testing Three Anti-Aging Drugs in Older Adults: A Clinical Trial Protocol
This is a well-designed but early-stage clinical trial protocol testing whether three anti-aging drugs can reverse aging biology in older adults—no results yet. It's a promising step toward human evidence, …
How mitochondrial DNA variants affect telomere length in human cells
This early-stage lab study suggests that variations in mitochondrial DNA inherited from your parents might influence how long your telomeres stay and thus how quickly cells age—but the evidence is …
Naked mole-rats handle cell stress differently: a closer look at their autophagy system
This is a clever proof-of-concept study showing that naked mole-rat cells handle stress in a distinctive way involving reversible vacuoles—an intriguing clue to their longevity. However, it's very early-stage work …
How CMV Drives Aging in HIV Patients—And What We Can Do About It
CMV is a hidden driver of accelerated aging in people with HIV, but it's druggable: early trials of antivirals and vaccines show promise, and larger studies could transform care. This …
Can senolytic drugs restore fertility in female mice with fatty liver disease?
A mouse study suggests senolytic drugs might improve fertility in females with fatty liver disease by reducing cellular aging in the ovaries, though they don't actually fix the liver disease. …
Can we reverse aging by partially reprogramming cells?
Partial reprogramming is a promising concept for reversing aging at the cellular level, with encouraging early results in animals. However, it remains largely unproven in humans—think of this as a …